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Study · Animal study (in vivo) · rat · 2023

6 results

Evaluation of protective effects of GnRH agonist or antagonist on ovarian reserve with anti-Müllerian hormone and histological analysis in a rat model using cisplatin.

Tas M, Oner G, Ulug P, Yavuz A, Ozcelik B

Archives of medical science : AMS27 Aug 2019Cited by 7 (Europe PMC)

PMID37034528 (opens in a new tab)PMCIDPMC10074176 (opens in a new tab)DOI10.5114/aoms.2019.87540 (opens in a new tab)PepBankPUB-37034528
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, secondary follicle counts were higher with triptorelin than with cisplatin alone.

    In plain wordsIn rats exposed to cisplatin, secondary follicle counts were higher with triptorelin than with cisplatin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSecondary follicle count
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Primary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11).
    3 context sentences
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, secondary follicle counts were higher with triptorelin than with cetrorelix.

    In plain wordsIn rats exposed to cisplatin, secondary follicle counts were higher with triptorelin than with cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseSecondary follicle count
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin plus cetrorelix
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Primary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11).
    4 context sentences
    Summary · context
    In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix.
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, primary follicle counts were lower with triptorelin than with cetrorelix.

    In plain wordsIn rats exposed to cisplatin, primary follicle counts were lower with triptorelin than with cetrorelix.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreasePrimary follicle count
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin plus cetrorelix
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Primary follicle counts were higher in group 2 (4.50 ±1.47 vs. 3.50 ±1.70 vs. 3.00 ±3.54) and secondary follicle counts were higher in group 1 (2.96 ±1.11 vs. 1.74 ±1.03 vs. 1.37 ±3.11).
    4 context sentences
    Summary · context
    In the GnRH antagonist group (group 2), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg cetrorelix.
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, triptorelin increased tertiary follicle counts versus cisplatin alone.

    In plain wordsIn rats exposed to cisplatin, triptorelin increased tertiary follicle counts versus cisplatin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTertiary follicle count
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Numbers of tertiary follicles were higher both in groups 1 and 2 than the control group (1.36 ±0.83 vs. 0.84 ±0.99 vs. 0.50 ±0.75).
    3 context sentences
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, triptorelin increased total follicle counts versus cisplatin alone.

    In plain wordsIn rats exposed to cisplatin, triptorelin increased total follicle counts versus cisplatin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTotal follicle count
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The total follicle count of the study groups were significantly higher compared with the control group (14.32 ±5.96 vs. 12.48 ±4.12 vs. 10.63 ±6.80).
    3 context sentences
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In cisplatin-exposed rats, triptorelin increased anti-Müllerian hormone versus cisplatin alone.

    In plain wordsIn rats exposed to cisplatin, triptorelin increased anti-Müllerian hormone versus cisplatin alone.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseAnti-Müllerian hormone
    Study

    ratn = 16

    Wistar albino rats exposed to cisplatin
    Comparator
    Cisplatin alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    1 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    AMH was significantly higher in groups 1 and 2 compared with the control group (18.56 ±25.33 vs. 16.48 ±24.66 vs. 9.37 ±26.54).
    3 context sentences
    Summary · context
    Twenty-four Wistar albino rats were randomly divided into three groups, each consisting of eight rats.
    Summary · context
    In the GnRH agonist group (group 1), rats received a single dose of 50 mg/m2 cisplatin with 1 mg/kg triptorelin.
    Summary · context
    In the control group (group 3), rats received 50 mg/m2 cisplatin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    22 Oct 2026, 02:26 UTC

    Study results updated

  3. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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