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Study · Animal study (in vivo) · mouse · 2023

8 results

Synthetic ERRα/β/γ Agonist Induces an ERRα-Dependent Acute Aerobic Exercise Response and Enhances Exercise Capacity.

Billon C, Sitaula S, Banerjee S, Welch R, Elgendy B, Hegazy L, Oh TG, Kazantzis M, Chatterjee A, Chrivia J, Hayes ME, Xu W and 7 more

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Hamilton A, Huss JM, Zhang L, Walker JK, Downes M, Evans RM, Burris TP

ACS chemical biology29 Mar 2023Cited by 40 (Europe PMC)

PMID36988910 (opens in a new tab)PMCIDPMC11584170 (opens in a new tab)DOI10.1021/acschembio.2c00720 (opens in a new tab)PepBankPUB-36988910
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, SLU‑PP‑332 increased type IIa oxidative skeletal muscle fibers.

    In plain wordsIn mice, SLU‑PP‑332 increased type IIa oxidative muscle fibers.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseType IIa oxidative muscle fibers
    Study

    mousen: not reported in source

    Exercise capacity model
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When administered to mice, SLU-PP-332 increased the type IIa oxidative skeletal muscle fibers and enhanced exercise endurance.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, SLU‑PP‑332 enhanced exercise endurance.

    In plain wordsIn mice, SLU‑PP‑332 improved exercise endurance.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseExercise endurance
    Study

    mousen: not reported in source

    Exercise capacity model
    Outcome group
    Exercise and physical function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    When administered to mice, SLU-PP-332 increased the type IIa oxidative skeletal muscle fibers and enhanced exercise endurance.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice, SLU‑PP‑332 induced an ERRα-specific acute aerobic exercise genetic program.

    In plain wordsIn mice, SLU‑PP‑332 induced an exercise genetic program specific to ERRα.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseERRα-specific exercise genetic program
    Study

    mousen: not reported in source

    Exercise capacity model
    Outcome group
    Receptor activity and mechanism · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    We also observed that SLU-PP-332 induced an ERRα-specific acute aerobic exercise genetic program, and the ERRα activation was critical for enhancing exercise endurance in mice.
  4. 04AnimalOther designPharmacokinetics

    SLU‑PP‑332 had sufficient pharmacokinetic properties for use as an in vivo chemical tool.

    In plain wordsSLU‑PP‑332 had pharmacokinetic properties sufficient for use as a chemical tool in living models.

    Peptide
    SLU-PP-332
    Outcome
    Not applicableSuitability for in vivo use
    Study

    n: not reported in source

    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Additionally, SLU-PP-332 has sufficient pharmacokinetic properties to be used as an in vivo chemical tool.
  5. 05LabIn vitro (cells)Mechanism

    In a skeletal muscle cell line, SLU‑PP‑332 increased mitochondrial function.

    In plain wordsIn cells from a skeletal muscle cell line, SLU‑PP‑332 increased mitochondrial function.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseMitochondrial function
    Study

    n: not reported in source

    Skeletal muscle cell line
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SLU-PP-332 increases mitochondrial function and cellular respiration in a skeletal muscle cell line.
  6. 06LabIn vitro (cells)Mechanism

    In a skeletal muscle cell line, SLU‑PP‑332 increased cellular respiration.

    In plain wordsIn cells from a skeletal muscle cell line, SLU‑PP‑332 increased cellular respiration.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseCellular respiration
    Study

    n: not reported in source

    Skeletal muscle cell line
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    SLU-PP-332 increases mitochondrial function and cellular respiration in a skeletal muscle cell line.
  7. 07LabOther designActivity measurement

    SLU‑PP‑332 targeted all three ERR subtypes and had the highest potency for ERRα.

    In plain wordsIn lab tests, SLU‑PP‑332 targeted all three ERR subtypes, with the highest potency for ERRα.

    Peptide
    SLU-PP-332
    Outcome
    IncreaseERR subtype activation and potency
    Study

    n: not reported in source

    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report the identification of a synthetic ERR pan agonist, SLU-PP-332, that targets all three ERRs but has the highest potency for ERRα.

Studies that did not test the peptide alone1

In this study, SLU-PP-332 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking SLU-PP-332.

  1. 08AnimalNot a test of SLU-PP-332 aloneAnimal study (in vivo)Mechanism

    In mice, ERRα activation was critical for SLU‑PP‑332-associated enhancement of exercise endurance.

    In plain wordsIn mice, ERRα activation was essential for the exercise endurance benefit associated with SLU‑PP‑332.

    Peptide
    SLU-PP-332
    Outcome
    Not applicableERRα dependence of endurance benefit
    Study

    mousen: not reported in source

    ERRα dependency experiments
    Outcome group
    Receptor activity and mechanism · Musculoskeletal

    Source sentences

    Summary
    We also observed that SLU-PP-332 induced an ERRα-specific acute aerobic exercise genetic program, and the ERRα activation was critical for enhancing exercise endurance in mice.

    In this study, SLU-PP-332 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking SLU-PP-332.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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