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Study · Animal study (in vivo) · mouse · 2023

5 results

Exogenous Thymosin Beta 4 Suppresses IPF-Lung Cancer in Mice: Possibly Associated with Its Inhibitory Effect on the JAK2/STAT3 Signaling Pathway.

Yu R, Gao D, Bao J, Sun R, Cui M, Mao Y, Li K, Hu E, Zhai Y, Liu Y, Gao Y, Xiao T, Zhou H, Yang C, Xu J

International journal of molecular sciences14 Feb 2023Cited by 5 (Europe PMC)

PMID36835236 (opens in a new tab)PMCIDPMC9965428 (opens in a new tab)DOI10.3390/ijms24043818 (opens in a new tab)PepBankPUB-36835236
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Summary

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial lung disease of unknown etiology. At present, the mortality rate of the deadly disease is still very high, while the existing treatments only delay the progression of the disease and improve the quality of life of patients. Lung cancer (LC) is the most fatal disease in the world. In recent years, IPF has been considered to be an independent risk factor for the development of LC. The incidence of lung cancer is increased in the patients with IPF and the mortality is also significantly increased in the patients inflicted with the two diseases. In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice. In vivo studies with the model showed that exogenous recombinant human thymosin beta 4 (exo-rhTβ4) alleviated the impairment of lung function and severity of damage of the alveolar structure by the pulmonary fibrosis and inhibited the proliferation of LC tumor growth. In addition, in vitro studies showed that exo-rhTβ4 inhibited the proliferation and migration of A549 and Mlg cells. Furthermore, our results also showed that rhTβ4 could effectively inhibit the JAK2-STAT3 signaling pathway and this might exert an anti-IPF-LC effect. The establishment of the IPF-LC animal model will be helpful for the development of drugs for the treatment of IPF-LC. Exogenous rhTβ4 can be potentially used for the treatment of IPF and LC.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis and lung cancer, exogenous recombinant human Tβ4 alleviated the impairment of lung function.

    In plain wordsIn mice with lung fibrosis and lung cancer, Tβ4 lessened the loss of lung function.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLung function in mice with pulmonary fibrosis and lung cancer
    Study

    mousen: not reported in source

    Outcome group
    Respiratory function · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo studies with the model showed that exogenous recombinant human thymosin beta 4 (exo-rhTβ4) alleviated the impairment of lung function
    1 context sentence
    Summary · context
    In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis and lung cancer, exogenous recombinant human Tβ4 alleviated the severity of damage of the alveolar structure.

    In plain wordsIn mice with lung fibrosis and lung cancer, Tβ4 lessened the damage to the air-sac structure of the lung.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseAlveolar structure damage
    Study

    mousen: not reported in source

    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    severity of damage of the alveolar structure by the pulmonary fibrosis and inhibited the proliferation of LC tumor growth.
    1 context sentence
    Summary · context
    In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with bleomycin-induced pulmonary fibrosis and lung cancer, exogenous recombinant human Tβ4 inhibited the proliferation of lung cancer tumor growth.

    In plain wordsIn mice with lung fibrosis and lung cancer, Tβ4 slowed the growth of the lung tumor.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseLung cancer tumor growth
    Study

    mousen: not reported in source

    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    inhibited the proliferation of LC tumor growth.
    1 context sentence
    Summary · context
    In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice.
  4. 04AnimalAnimal study (in vivo)Mechanism

    Recombinant human Tβ4 inhibited the JAK2-STAT3 signaling pathway, which might exert an anti-IPF-LC effect.

    In plain wordsIn mice, Tβ4 lowered activity of the JAK2-STAT3 pathway, which may help explain its effect on lung fibrosis and lung cancer.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseJAK2-STAT3 signaling pathway
    Study

    mousen: not reported in source

    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, our results also showed that rhTβ4 could effectively inhibit the JAK2-STAT3 signaling pathway and this might exert an anti-IPF-LC effect.
    1 context sentence
    Summary · context
    In this study, we evaluated an animal model of pulmonary fibrosis complicated with LC by implanting LC cells orthotopically into the lungs of mice several days after bleomycin induction of the pulmonary fibrosis in the same mice.
  5. 05LabIn vitro (cells)Efficacy outcome

    In vitro, exogenous recombinant human Tβ4 inhibited the proliferation and migration of A549 and Mlg cells.

    In plain wordsIn lab tests, Tβ4 slowed the growth and movement of A549 and Mlg cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseProliferation and migration of A549 and Mlg cells
    Study

    n: not reported in source

    A549 and Mlg cells
    Outcome group
    Tumor growth · Cancer
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, in vitro studies showed that exo-rhTβ4 inhibited the proliferation and migration of A549 and Mlg cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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