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Study · Animal study (in vivo) · mouse · 2023

7 results

Nicotinamide mononucleotide alters body composition and ameliorates metabolic disorders induced by a high-fat diet.

Zhang Y, Zhu W, Wang M, Xi P, Wang H, Tian D

IUBMB life13 Feb 2023Cited by 14 (Europe PMC)

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN reduced fat mass.

    In plain wordsIn mice with obesity, NMN reduced fat mass.

    Outcome
    DecreaseFat mass
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the current study, we showed that NMN intervention altered body composition in obese mice, characterized by a reduction in fat mass and an increase in lean mass.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN increased lean mass.

    In plain wordsIn mice with obesity, NMN increased lean mass.

    Outcome
    IncreaseLean mass
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In the current study, we showed that NMN intervention altered body composition in obese mice, characterized by a reduction in fat mass and an increase in lean mass.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN reversed high-fat diet-induced blood lipid changes.

    In plain wordsIn mice with obesity, NMN reversed blood lipid changes caused by a high-fat diet.

    Outcome
    Direction not reportedBlood lipids
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Lipids · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN reversed high-fat diet-induced blood lipid levels then contributed to reducing hepatic steatosis.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN reduced hepatic steatosis.

    In plain wordsIn mice with obesity, NMN reduced liver fat accumulation.

    Outcome
    DecreaseHepatic steatosis
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN reversed high-fat diet-induced blood lipid levels then contributed to reducing hepatic steatosis.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN improved glucose tolerance.

    In plain wordsIn mice with obesity, NMN improved glucose tolerance.

    Outcome
    IncreaseGlucose tolerance
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN also improved glucose tolerance and alleviated adipose tissue inflammation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In obese mice, NMN alleviated adipose tissue inflammation.

    In plain wordsIn mice with obesity, NMN reduced adipose tissue inflammation.

    Outcome
    DecreaseAdipose inflammation
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Inflammation markers · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN also improved glucose tolerance and alleviated adipose tissue inflammation.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In obese mice, NMN regulation of brown adipose metabolism may depend on the NAD/SIRT6/LKB1 pathway.

    In plain wordsIn mice with obesity, NMN regulation of brown fat metabolism may depend on the NAD/SIRT6/LKB1 pathway.

    Outcome
    Direction not reportedBrown adipose metabolism pathway
    Study

    mousen: not reported in source

    high-fat diet-induced obesity
    Outcome group
    Receptor activity and mechanism · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Moreover, our data suggested that NMN supplementation may be depends on the NAD+ /SIRT6/LKB1 pathway to regulate brown adipose metabolism.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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