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Study · Other design · mouse · 2023

1 result

Nicotinamide mononucleotide restores oxidative stress-related apoptosis of oocyte exposed to benzyl butyl phthalate in mice.

Jiang Y, Wang D, Zhang C, Jiao Y, Pu Y, Cheng R, Li C, Chen Y

Cell proliferation9 Feb 2023Cited by 19 (Europe PMC)

PMID36756972 (opens in a new tab)PMCIDPMC10392047 (opens in a new tab)DOI10.1111/cpr.13419 (opens in a new tab)PepBankPUB-36756972
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Summary

Benzyl butyl phthalate (BBP) is a chemical softener and plasticizer commonly used in toys, food packaging, wallpaper, detergents and shampoos. The estrogenic actions of BBP have detrimental effects on humans and animals. In this study, the specific influence of BBP on mouse oocyte maturation was investigated using in vivo and in vitro models. The experiment first verified that BBP exposure significantly affected the rate of oocyte exclusion of the first polar body, although it did not affect germinal vesicle breakdown (GVBD) through in vitro oocyte culture system. Results of in vitro fertilization show that BBP exposure affects blastocyst rate. Subsequently, the results obtained by immunofluorescence staining technology showed that oocyte spindle organization, chromosomal arrangement and the distribution of cortical actin were disrupted by BBP exposure, and led to the failure of oocyte meiotic maturation and the subsequent early embryo development. Singe-cell transcriptome analysis found that BBP exposure altered the expression levels of 588 genes, most associated with mitochondria-related oxidative stress. Further analysis demonstrated that the detrimental effects of BBP involved the disruption of mitochondrial function and oxidative stress-induced early apoptosis. Nicotinamide mononucleotide (NMN) supplementation reduced the adverse effects of BBP. Collectively, these findings revealed a mechanism of BBP-induced toxicity on female reproduction and showed that NMN provides an effective treatment for BBP actions.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalOther designEfficacy outcome

    In mouse oocyte experiments, NMN supplementation reduced adverse effects of BBP exposure.

    In plain wordsIn mouse oocyte experiments, NMN reduced adverse effects of BBP exposure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBBP adverse effects
    Study

    mousen: not reported in source

    BBP-exposed oocytes
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Nicotinamide mononucleotide (NMN) supplementation reduced the adverse effects of BBP.
    1 context sentence
    Summary · context
    In this study, the specific influence of BBP on mouse oocyte maturation was investigated using in vivo and in vitro models.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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