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Study · Animal study (in vivo) · rat · 2023

6 results

Effect of Carnosine on the Activity of Matrix Metalloproteinase-2 and Oxidative Stress in the Kidneys in Experimental Urate Nephrolithiasis.

Zharikov AY, Kalnitsky AS, Mazko ON, Makarova OG, Bobrov IP

Bulletin of experimental biology and medicine1 Jan 2023Cited by 1 (Europe PMC)

PMID36723739 (opens in a new tab)DOI10.1007/s10517-023-05701-9 (opens in a new tab)PepBankPUB-36723739
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with urate nephrolithiasis, carnosine decreased urinary MMP-2 concentration by 3.7 times.

    In plain wordsIn rats with urate kidney stones, carnosine decreased urinary MMP-2 concentration by 3.7 times.

    Peptide
    L-carnosine
    Outcome
    DecreaseUrinary MMP-2 concentration
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    In rats treated with carnosine, the concentration of MMP-2 in the urine decreased by 3.7 times, and the excretion of MMP-2 with urine decreased by 4.3 times.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with urate nephrolithiasis, carnosine decreased urinary MMP-2 excretion by 4.3 times.

    In plain wordsIn rats with urate kidney stones, carnosine decreased urinary MMP-2 excretion by 4.3 times.

    Peptide
    L-carnosine
    Outcome
    DecreaseUrinary MMP-2 excretion
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    In rats treated with carnosine, the concentration of MMP-2 in the urine decreased by 3.7 times, and the excretion of MMP-2 with urine decreased by 4.3 times.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats with urate nephrolithiasis, carnosine decreased renal TBA-reactive substances by 5 times.

    In plain wordsIn rats with urate kidney stones, carnosine decreased kidney TBA-reactive substances by 5 times.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal TBA-reactive substances
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    In the homogenate of the kidneys from rats treated with carnosine, the concentration of TBA-reactive substances decreased by 5 times and the concentration of MMP-2 decreased by 12.7%.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with urate nephrolithiasis, carnosine decreased renal MMP-2 concentration by 12.7%.

    In plain wordsIn rats with urate kidney stones, carnosine decreased kidney MMP-2 concentration by 12.7%.

    Peptide
    L-carnosine
    Outcome
    DecreaseRenal MMP-2 concentration
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    In the homogenate of the kidneys from rats treated with carnosine, the concentration of TBA-reactive substances decreased by 5 times and the concentration of MMP-2 decreased by 12.7%.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats, histologically confirmed urate nephrolithiasis cases decreased by 2 times after carnosine treatment.

    In plain wordsIn rats, confirmed urate kidney stone cases decreased by 2 times after carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    DecreaseHistologically confirmed nephrolithiasis
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    After treatment with carnosine, the number of histologically confirmed cases of urate nephrolithiasis decreased by 2 times, while the mean size of urate deposits decreased by 2.7 times.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats, mean urate deposit size decreased by 2.7 times after carnosine treatment.

    In plain wordsIn rats, mean urate deposit size decreased by 2.7 times after carnosine treatment.

    Peptide
    L-carnosine
    Outcome
    DecreaseMean urate deposit size
    Study

    ratn: not reported in source

    Wistar rats with experimental urate nephrolithiasis
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    15 mg/kg · intragastricAs given in this study (rat).

    Source sentences

    Summary
    After treatment with carnosine, the number of histologically confirmed cases of urate nephrolithiasis decreased by 2 times, while the mean size of urate deposits decreased by 2.7 times.
    2 context sentences
    Summary · context
    Urate nephrolithiasis was modeled in Wistar rats by intragastric administration of a mixture of oxonic and uric acids.
    Summary · context
    Carnosine was administered intragastrically through a tube in a dose of 15 mg/kg.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

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