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Study · Randomized controlled trial · n = 60 · 2023

5 results

Comparison of glucose control by added liraglutide to only insulin infusion in diabetic patient undergoing cardiac surgery: A preliminary randomized-controlled trial.

Sindhvananda W, Poopuangpairoj W, Jaiprasat T, Ongcharit P

Annals of cardiac anaesthesia1 Jan 2023Cited by 10 (Europe PMC)

PMID36722590 (opens in a new tab)PMCIDPMC9997471 (opens in a new tab)DOI10.4103/aca.aca_214_20 (opens in a new tab)PepBankPUB-36722590
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, adding liraglutide to insulin infusion gave lower perioperative mean blood glucose than insulin alone (difference 15.9 mg/dL).

    In plain wordsIn adults with diabetes having heart surgery, adding liraglutide to insulin gave lower blood sugar than insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreasePerioperative mean blood glucose
    Study

    n = 60

    Comparator
    Insulin infusion alone
    Analysis
    Primary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean BG difference
    15.9 mg/dL
    Group 1 vs Group 2

    Source sentences

    Summary
    Perioperative mean BG levels of Group 1 were significantly lower than Group 2 with a mean difference of 15.9 mg/dL.
    2 context sentences
    Summary · context
    A randomized control trial was conducted in DM patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
    Summary · context
    : The recruited patients were randomly assigned to Group 1 (added liraglutide with insulin infusion) and Group 2 (insulin infusion).
  2. 02HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, glycemic variability was lower with liraglutide plus insulin at the postoperative period; SD at postoperative day 2 was 23.65 vs 32.79 mg/dL (P = 0.018).

    In plain wordsIn adults with diabetes having heart surgery, blood sugar swings after surgery were smaller with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseGlycemic variability (SD of glucose), postoperative period
    Study

    n = 60

    Comparator
    Insulin infusion alone
    Analysis
    Primary
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    SD of BG at postoperative day 2
    23.65 mg/dL
    liraglutide plus insulin
    SD of BG at postoperative day 2
    32.79 mg/dL
    insulin alone

    Source sentences

    Summary
    SDs were increasing, but lower SD of Group 1 were observed at the postoperative period. Mean of SDs at postoperative day 2 were 23.65 vs 32.79 mg/dL, P = 0.018.
    2 context sentences
    Summary · context
    A randomized control trial was conducted in DM patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
    Summary · context
    : The recruited patients were randomly assigned to Group 1 (added liraglutide with insulin infusion) and Group 2 (insulin infusion).
  3. 03HumanRandomized controlled trialSafety outcome

    In adults with type 2 diabetes undergoing cardiac surgery, a blood glucose of 60-70 was recorded in 18.7% with liraglutide plus insulin versus 10.7% with insulin alone, with no significant difference (P = 0.384).

    In plain wordsIn adults with diabetes having heart surgery, blood sugar readings of 60-70 were not significantly more common with liraglutide plus insulin.

    Peptide
    Liraglutide
    Outcome
    No significant changeBlood glucose of 60-70 mg/dL
    Study

    n = 60

    Comparator
    Insulin infusion alone
    Outcome group
    Adverse events · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Proportion with BG 60-70
    18.7%
    liraglutide plus insulin
    Proportion with BG 60-70
    10.7%
    insulin alone

    Source sentences

    Summary
    Nine patients (18.7% vs 10.7%, P = 0.384)
    2 context sentences
    Summary · context
    A randomized control trial was conducted in DM patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
    Summary · context
    : The recruited patients were randomly assigned to Group 1 (added liraglutide with insulin infusion) and Group 2 (insulin infusion).
  4. 04HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, fewer patients had blood glucose above 180 mg/dL at the first operative hour with liraglutide plus insulin (9.4% vs 35.7%, P = 0.025).

    In plain wordsIn adults with diabetes having heart surgery, fewer patients had high blood sugar in the first operating hour with liraglutide plus insulin than insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseBlood glucose above 180 mg/dL at first operative hour
    Study

    n = 60

    Comparator
    Insulin infusion alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Proportion with BG >180
    9.4%
    liraglutide plus insulin
    Proportion with BG >180
    35.7%
    insulin alone

    Source sentences

    Summary
    Thirteen patients (9.4% vs 35.7%, P = 0.025) had BG >180 mg/dL at the 1st operative hour.
    2 context sentences
    Summary · context
    A randomized control trial was conducted in DM patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
    Summary · context
    : The recruited patients were randomly assigned to Group 1 (added liraglutide with insulin infusion) and Group 2 (insulin infusion).
  5. 05HumanRandomized controlled trialEfficacy outcome

    In adults with type 2 diabetes undergoing cardiac surgery, morning mean blood glucose was lower with liraglutide plus insulin than with insulin alone (109.1 vs 147.9, P = 0.001).

    In plain wordsIn adults with diabetes having heart surgery, morning blood sugar was lower with liraglutide plus insulin than with insulin alone.

    Peptide
    Liraglutide
    Outcome
    DecreaseMorning blood glucose
    Study

    n: not reported in source

    Comparator
    Insulin infusion alone
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    Mean morning BG
    109.1
    liraglutide plus insulin
    Mean morning BG
    147.9
    insulin alone

    Source sentences

    Summary
    Nine patients (18.7% vs 10.7%, P = 0.384) had BG of 60-70 with mean BGs (109.1 vs 147.9, P = 0.001) in the morning.
    2 context sentences
    Summary · context
    A randomized control trial was conducted in DM patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
    Summary · context
    : The recruited patients were randomly assigned to Group 1 (added liraglutide with insulin infusion) and Group 2 (insulin infusion).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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