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Study · Animal study (in vivo) · mouse · 2023

4 results

Nicotinamide Mononucleotide Ameliorates Sleep Deprivation-Induced Gut Microbiota Dysbiosis and Restores Colonization Resistance against Intestinal Infections.

Fang D, Xu T, Sun J, Shi J, Li F, Yin Y, Wang Z, Liu Y

Advanced science (Weinheim, Baden-Wurttemberg, Germany)25 Jan 2023Cited by 37 (Europe PMC)

PMID36698264 (opens in a new tab)PMCIDPMC10037695 (opens in a new tab)DOI10.1002/advs.202207170 (opens in a new tab)PepBankPUB-36698264
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Summary

Gut microbiota-mediated colonization resistance (CR) is crucial in protecting the host from intestinal infections. Sleep deprivation (SD) is an important contributor in the disturbances of intestinal homeostasis. However, whether and how SD affects host CR remains largely unknown. Here, it is shown that SD impairs intestinal CR in mice, whereas nicotinamide mononucleotide (NMN) supplementation restores it. Microbial diversity and metabolomic analyses suggest that gut microbiota and metabolite profiles in SD-treated mice are highly shaped, whereas NMN reprograms these differences. Specifically, the altered gut microbiota in SD mice further incurs the disorder of secondary bile acids pool accompanied by a decrease in deoxycholic acid (DCA). Conversely, NMN supplementation retakes the potential benefits of DCA, which is associated with specific gut microbiota involved in primary bile acids metabolic flux. In animal models of infection, DCA is effective in preventing and treating bacterial infections when used alone or in combination with antibiotics. Mechanistically, DCA alone disrupts membrane permeability and aggravates oxidative damage, thereby reducing intestinal pathogen burden. Meanwhile, exogenous DCA promotes antibiotic accumulation and destroys oxidant-antioxidant system, thus potentiating antibiotic efficacy. Overall, this work highlights the important roles of gut microbiota and bile acid metabolism in the maintenance of intestinal CR.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In sleep-deprived mice, NMN restored impaired intestinal colonization resistance.

    In plain wordsIn mice with sleep deprivation, NMN restored impaired intestinal resistance to colonization.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseIntestinal colonization resistance
    Study

    mousen: not reported in source

    sleep deprivation
    Outcome group
    Infection and antimicrobial activity · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, it is shown that SD impairs intestinal CR in mice, whereas nicotinamide mononucleotide (NMN) supplementation restores it.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In sleep-deprived mice, NMN reprogrammed altered gut microbiota profiles.

    In plain wordsIn mice with sleep deprivation, NMN changed altered gut microbiota profiles.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedGut microbiota profiles
    Study

    mousen: not reported in source

    sleep deprivation
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microbial diversity and metabolomic analyses suggest that gut microbiota and metabolite profiles in SD-treated mice are highly shaped, whereas NMN reprograms these differences.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In sleep-deprived mice, NMN reprogrammed altered metabolite profiles.

    In plain wordsIn mice with sleep deprivation, NMN changed altered metabolite profiles.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedMetabolite profiles
    Study

    mousen: not reported in source

    sleep deprivation
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Microbial diversity and metabolomic analyses suggest that gut microbiota and metabolite profiles in SD-treated mice are highly shaped, whereas NMN reprograms these differences.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In sleep-deprived mice, NMN restored potential DCA benefits associated with microbiota involved in primary bile acid metabolic flux.

    In plain wordsIn mice with sleep deprivation, NMN restored potential DCA benefits linked to gut microbes involved in bile acid metabolism.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedDCA-associated benefits
    Study

    mousen: not reported in source

    sleep deprivation
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Conversely, NMN supplementation retakes the potential benefits of DCA, which is associated with specific gut microbiota involved in primary bile acids metabolic flux.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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