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Study · In vitro (cells) · 2023

2 results

Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein.

Meanti R, Licata M, Rizzi L, Bresciani E, Molteni L, Coco S, Locatelli V, Omeljaniuk RJ, Torsello A

International journal of molecular sciences4 Jan 2023Cited by 3 (Europe PMC)

PMID36674509 (opens in a new tab)PMCIDPMC9863688 (opens in a new tab)DOI10.3390/ijms24020993 (opens in a new tab)PepBankPUB-36674509
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Summary

Amyotrophic lateral sclerosis (ALS) is an incurable motor neuron disease whose etiology remains unresolved; nonetheless, mutations of superoxide dismutase 1 (SOD1) have been associated with several variants of ALS. Currently available pharmacologic interventions are only symptomatic and palliative in effect; therefore, there is a pressing demand for more effective drugs. This study examined potential therapeutic effects of growth hormone secretagogues (GHSs), a large family of synthetic compounds, as possible candidates for the treatment of ALS. Human neuroblastoma cells expressing the SOD1-G93A mutated protein (SH-SY5Y SOD1G93A cells) were incubated for 24 h with H2O2 (150 µM) in the absence, or presence, of GHS (1 µM), in order to study the protective effect of GHS against increased oxidative stress. The two GHSs examined in this study, hexarelin and JMV2894, protected cells from H2O2-induced cytotoxicity by activating molecules that regulate apoptosis and promote cell survival processes. These findings suggest the possibility of developing new GHS-based anti-oxidant and neuroprotective drugs with improved therapeutic potential. Further investigations are required for the following: (i) to clarify GHS molecular mechanisms of action, and (ii) to envisage the development of new GHSs that may be useful in ALS therapy.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human neuroblastoma cells expressing SOD1-G93A, hexarelin protected cells from H2O2-induced cytotoxicity.

    In plain wordsIn cells, hexarelin protected neuroblastoma cells carrying the SOD1-G93A mutation from damage caused by hydrogen peroxide.

    Peptide
    Hexarelin
    Outcome
    DecreaseProtection from H2O2-induced cytotoxicity
    Study

    humann: not reported in source

    SH-SY5Y SOD1G93A neuroblastoma cells with H2O2 challenge
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 µM · 24 hAs given in this study (human).

    Source sentences

    Summary
    The two GHSs examined in this study, hexarelin and JMV2894, protected cells from H2O2-induced cytotoxicity by activating molecules that regulate apoptosis and promote cell survival processes.
    1 context sentence
    Summary · context
    Human neuroblastoma cells expressing the SOD1-G93A mutated protein (SH-SY5Y SOD1G93A cells) were incubated for 24 h with H2O2 (150 µM) in the absence, or presence, of GHS (1 µM), in order to study the protective effect of GHS against increased oxidative stress.
  2. 02LabIn vitro (cells)Mechanism

    In human neuroblastoma cells expressing SOD1-G93A, hexarelin protection from H2O2 cytotoxicity was achieved by activating molecules that regulate apoptosis and promote cell survival.

    In plain wordsIn cells, hexarelin's protection from hydrogen peroxide damage worked by switching on molecules that control cell death and survival.

    Peptide
    Hexarelin
    Outcome
    IncreaseActivation of apoptosis-regulating and cell-survival molecules
    Study

    humann: not reported in source

    SH-SY5Y SOD1G93A neuroblastoma cells with H2O2 challenge
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    1 µM · 24 hAs given in this study (human).

    Source sentences

    Summary
    protected cells from H2O2-induced cytotoxicity by activating molecules that regulate apoptosis and promote cell survival processes
    1 context sentence
    Summary · context
    Human neuroblastoma cells expressing the SOD1-G93A mutated protein (SH-SY5Y SOD1G93A cells) were incubated for 24 h with H2O2 (150 µM) in the absence, or presence, of GHS (1 µM), in order to study the protective effect of GHS against increased oxidative stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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