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Study · In vitro (cells) · grass carp · 2023

2 results

Molecular cloning and functional characterization of melanocortin-3 receptor in grass carp (Ctenopharyngodon idella).

Mo H, Yu H, Li Y, Ezeorba TPC, Zhang Z, Yao M, Yu J, Xiong D, Liu H, Wang L

Fish physiology and biochemistry22 Dec 2022Cited by 5 (Europe PMC)

PMID36547499 (opens in a new tab)DOI10.1007/s10695-022-01164-3 (opens in a new tab)PepBankPUB-36547499
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In HEK293T cells expressing grass carp MC3R, NDP-MSH, with α-MSH, β-MSH and ACTH, potentiated receptor activation and increased cAMP production.

    In plain wordsIn lab cells with the grass carp receptor, NDP-MSH and three other agonists raised cAMP.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP production via grass carp MC3R
    Study

    grass carpn: not reported in source

    HEK293T cells co-transfected with ciMC3R and a luciferase reporter
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results revealed that the four agonists, α-MSH, β-MSH, ACTH, and NDP-MSH, potentiate the activation of ciMC3R and further increase the production of cAMP
    1 context sentence
    Summary · context
    The cytological function of ciMC3R was investigated by the co-transfection of pcDNA3.1-ciMC3R and the signal-pathway-specific luciferase into the HEK293T cells.
  2. 02LabIn vitro (cells)Activity measurement

    In HEK293T cells expressing grass carp MC3R, NDP-MSH, with α-MSH, β-MSH and ACTH, upregulated MAPK/ERK signaling.

    In plain wordsIn lab cells with the grass carp receptor, NDP-MSH and three other agonists raised MAPK/ERK signaling.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMAPK/ERK signaling via grass carp MC3R
    Study

    grass carpn: not reported in source

    HEK293T cells co-transfected with ciMC3R and a luciferase reporter
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Results revealed that the four agonists, α-MSH, β-MSH, ACTH, and NDP-MSH, potentiate the activation of ciMC3R and further increase the production of cAMP and upregulate the MAPK/ERK signaling, respectively.
    1 context sentence
    Summary · context
    The cytological function of ciMC3R was investigated by the co-transfection of pcDNA3.1-ciMC3R and the signal-pathway-specific luciferase into the HEK293T cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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