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Study · In silico · 2023

3 results

The preliminary study of exosomes derived from thymosin beta 4-treated adipose-derived stem cells in fat grafting.

Li W, Yang Y, Zhang X, Lin Y, Li H, Yao Y, Mu D, Mu D

Genes & genomics29 Nov 2022Cited by 1 (Europe PMC)

PMID36445571 (opens in a new tab)DOI10.1007/s13258-022-01329-7 (opens in a new tab)PepBankPUB-36445571
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01Computer modelIn silicoMechanism

    Prediction databases screened 621 overlapping genes for the up-regulated and 572 for the down-regulated differentially expressed miRNAs.

    In plain wordsA computer prediction listed genes that these miRNAs may control. It is not a measured effect.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicablePredicted overlapping downstream genes of differentially expressed miRNAs
    Study

    n: not reported in source

    Prediction databases
    Outcome group
    Receptor activity and mechanism · Skin and wound
    Studied dose
    Dose not stated

    Measurements

    Overlapping genes, up-regulated DEMs
    621 genes
    prediction
    Overlapping genes, down-regulated DEMs
    572 genes
    prediction

    Source sentences

    Summary
    After the prediction, 621 overlapping genes for the up-regulated and 572 for the down-regulated DEMs were screened.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Efficacy outcome

    In cell assays, exosomes from Tβ4-treated adipose-derived stem cells increased endothelial cell growth rate compared with the control group.

    In plain wordsIn cells, tiny vesicles from fat stem cells that were exposed to Tβ4 made blood vessel lining cells grow faster than control vesicles.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseEndothelial cell growth rate with Tβ4-Exos
    Study

    n: not reported in source

    Adipose-derived stem cells and endothelial cells
    Comparator
    Control (DMEM-H + PBS)
    Outcome group
    Cell proliferation and differentiation · Skin and wound

    Source sentences

    Summary
    The exosome uptake and CCK-8 assays showed that the Tβ4-Exos could increase cell growth rate compared with the control group (DMEM-H + PBS).
    1 context sentence
    Summary · context
    Depending on whether the medium was supplemented with exogenous Tβ4 or not, exosomes derived from cultured ADSCs were divided into the Tβ4-Exos group and Con-Exos group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    Compared with exosomes from untreated cells, exosomes from Tβ4-treated cells had 80 up-regulated and 99 down-regulated differentially expressed miRNAs.

    In plain wordsVesicles from fat stem cells exposed to Tβ4 held 80 microRNAs that were higher and 99 that were lower than in control vesicles.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    MixedExosomal miRNA profile of Tβ4-Exos versus Con-Exos
    Study

    n: not reported in source

    Adipose-derived stem cells and endothelial cells
    Comparator
    Con-Exos
    Outcome group
    Receptor activity and mechanism · Skin and wound

    Measurements

    Up-regulated DEMs
    80 miRNAs
    Tβ4-Exos vs Con-Exos
    Down-regulated DEMs
    99 miRNAs
    Tβ4-Exos vs Con-Exos

    Source sentences

    Summary
    In Tβ4-Exos and Con-Exos groups, 2651 exosomal miRNAs were recognized, with 80 up-regulated and 99 down-regulated DEMs according to the criteria.
    1 context sentence
    Summary · context
    Depending on whether the medium was supplemented with exogenous Tβ4 or not, exosomes derived from cultured ADSCs were divided into the Tβ4-Exos group and Con-Exos group.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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