Effects of intracerebroventricular and intravenous administration of Kisspeptin-54 and Gonadotropin-releasing hormone agonist in rats with ovarian hyperstimulation.

Bilister Egilmez C, Koyu A, Azak Pazarlar B, Keselik E, Oz Oyar E, Kurus M

Neuropeptides20 Oct 2022Cited by 2 (Europe PMC)

PMID36367482DOI10.1016/j.npep.2022.102298PepBankPUB-36367482

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local and systemic kisspeptin‑54 lowered ovarian VEGFa immunoreactivity.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given into the brain or into a vein lowered a marker of ovarian inflammation, VEGFa.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseOvarian VEGFa immunoreactivity
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated · intracerebroventricular and intravenousAs given in this study (rat).
Source sentences
Summary
The optical densities of VEGFa, IL-1β, TNF- α and MCP-1 immunoreactivity showed us that both local and systemic applied kisspeptin-54 attenuates the level of investigated inflammation parameters in the ovaries.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748201
02AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local and systemic kisspeptin‑54 lowered ovarian IL-1β immunoreactivity.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given into the brain or into a vein lowered a marker of ovarian inflammation, IL-1β.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseOvarian IL-1β immunoreactivity
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated · intracerebroventricular and intravenousAs given in this study (rat).
Source sentences
Summary
The optical densities of VEGFa, IL-1β, TNF- α and MCP-1 immunoreactivity showed us that both local and systemic applied kisspeptin-54 attenuates the level of investigated inflammation parameters in the ovaries.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748202
03AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local and systemic kisspeptin‑54 lowered ovarian TNF-α immunoreactivity.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given into the brain or into a vein lowered a marker of ovarian inflammation, TNF-α.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseOvarian TNF-α immunoreactivity
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated · intracerebroventricular and intravenousAs given in this study (rat).
Source sentences
Summary
The optical densities of VEGFa, IL-1β, TNF- α and MCP-1 immunoreactivity showed us that both local and systemic applied kisspeptin-54 attenuates the level of investigated inflammation parameters in the ovaries.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748203
04AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local and systemic kisspeptin‑54 lowered ovarian MCP-1 immunoreactivity.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given into the brain or into a vein lowered a marker of ovarian inflammation, MCP-1.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseOvarian MCP-1 immunoreactivity
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Inflammation markers · Reproductive and sexual health
Studied dose
Dose not stated · intracerebroventricular and intravenousAs given in this study (rat).
Source sentences
Summary
The optical densities of VEGFa, IL-1β, TNF- α and MCP-1 immunoreactivity showed us that both local and systemic applied kisspeptin-54 attenuates the level of investigated inflammation parameters in the ovaries.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748204
05AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local kisspeptin‑54 increased Kiss1R mRNA in the ovaries.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given locally raised the mRNA of its own receptor, Kiss1R, in the ovaries.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKiss1R mRNA in the ovaries
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · localAs given in this study (rat).
Source sentences
Summary
Moreover, local administration of kisspeptin-54 has been shown to enhance the level of Kiss1R mRNA in both the ovaries and the hypothalamus.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748205
06AnimalAnimal study (in vivo)Mechanism
In rats with ovarian hyperstimulation, local kisspeptin‑54 increased Kiss1R mRNA in the hypothalamus.
In plain wordsIn rats with ovarian hyperstimulation, kisspeptin‑54 given locally raised the mRNA of its own receptor, Kiss1R, in the hypothalamus.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseKiss1R mRNA in the hypothalamus
Study
ratn: not reported in source
Ovarian hyperstimulation model (PMSG and hCG) in immature female rats
Outcome group
Receptor activity and mechanism · Endocrine and hormones
Studied dose
Dose not stated · localAs given in this study (rat).
Source sentences
Summary
Moreover, local administration of kisspeptin-54 has been shown to enhance the level of Kiss1R mRNA in both the ovaries and the hypothalamus.
2 context sentences(design, population, supporting numbers)
Summary · context
In order to generate the ovarian hyperstimulation model, 50 IU PMSG was administered for 4 consecutive days and a single dose of 25 IU hCG was administered to all groups except for the sham group.
Summary · context
Kisspeptin-54 and gonadotropin-releasing hormone (GnRH) agonists were administered 48 h after hCG injection.
Report a problemFND-3636748206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

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