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Study · Animal study (in vivo) · horse · 2023

5 results

Detection of the growth hormone secretagogue MK-0677 in equine hair following oral administration.

Viljanto M, Cutler C, Taylor P, Habershon-Butcher J, Gray B

Drug testing and analysis19 Dec 2022Cited by 6 (Europe PMC)

PMID36354265 (opens in a new tab)DOI10.1002/dta.3406 (opens in a new tab)PepBankPUB-36354265
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Pharmacokinetics

    After oral administration to a Thoroughbred racehorse, MK-0677 was detected in all collected mane hair samples up to 209 days.

    In plain wordsIn a horse, MK-0677 remained detectable in collected mane hair samples up to 209 days after oral dosing.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableMane hair detection
    Study

    horsen = 1

    Thoroughbred racehorse
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (horse).

    Measurements

    Detection window
    209 days
    mane hair

    Source sentences

    Summary
    This enabled the detection of MK-0677 in all hair samples collected, up to 209 days in mane and 358 days in tail.
    1 context sentence
    Summary · context
    The aim of the current study was to investigate whether it could be detected in equine hair following oral administration of MK-0677 mesylate to a Thoroughbred racehorse.
  2. 02AnimalAnimal study (in vivo)Pharmacokinetics

    After oral administration to a Thoroughbred racehorse, MK-0677 was detected in all collected tail hair samples up to 358 days.

    In plain wordsIn a horse, MK-0677 remained detectable in collected tail hair samples up to 358 days after oral dosing.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableTail hair detection
    Study

    horsen = 1

    Thoroughbred racehorse
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (horse).

    Measurements

    Detection window
    358 days
    tail hair

    Source sentences

    Summary
    This enabled the detection of MK-0677 in all hair samples collected, up to 209 days in mane and 358 days in tail.
    1 context sentence
    Summary · context
    The aim of the current study was to investigate whether it could be detected in equine hair following oral administration of MK-0677 mesylate to a Thoroughbred racehorse.
  3. 03AnimalAnimal study (in vivo)Pharmacokinetics

    In a Thoroughbred racehorse, hair wash criteria indicated internal MK-0677 incorporation at later time points of at least 52 days.

    In plain wordsIn a horse, hair wash tests indicated internal MK-0677 incorporation at later sampling times.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableLate hair incorporation
    Study

    horsen = 1

    Thoroughbred racehorse
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (horse).

    Source sentences

    Summary
    Wash criteria to differentiate between internal incorporation (via bloodstream) and external deposition (via sweat and sebum) was also assessed and indicated internal incorporation for the samples collected at later time points (≥52 days)
    1 context sentence
    Summary · context
    The aim of the current study was to investigate whether it could be detected in equine hair following oral administration of MK-0677 mesylate to a Thoroughbred racehorse.
  4. 04AnimalAnimal study (in vivo)Pharmacokinetics

    In a Thoroughbred racehorse, hair wash criteria indicated both internal MK-0677 incorporation and external deposition at 2 days.

    In plain wordsIn a horse, hair wash tests indicated both internal MK-0677 incorporation and external deposition at 2 days.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableEarly hair deposition and incorporation
    Study

    horsen = 1

    Thoroughbred racehorse
    Outcome group
    Pharmacokinetics · Pharmacology
    Studied dose
    Dose not stated · oralAs given in this study (horse).

    Source sentences

    Summary
    and a combination of internal incorporation and external deposition for hair samples collected at the earlier time point (2 days).
    1 context sentence
    Summary · context
    The aim of the current study was to investigate whether it could be detected in equine hair following oral administration of MK-0677 mesylate to a Thoroughbred racehorse.

Studies that did not test the peptide alone1

In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking MK-677 (ibutamoren).

  1. 05LabNot a test of MK-677 (ibutamoren) aloneIn vitro (cell-free)Other

    An extensive wash procedure verified MK-0677 presence in selected equine hair samples.

    In plain wordsIn lab tests, extensive washing confirmed MK-0677 in selected horse hair samples.

    Peptide
    MK-677 (ibutamoren)
    Outcome
    Not applicableDetection after extensive washing
    Study

    horsen: not reported in source

    selected equine hair samples
    Outcome group
    Analytical methods and detection · Pharmacology

    Source sentences

    Summary
    A follow-up methodology with an extensive wash procedure was carried out for selected hair samples, which unambiguously verified the presence of MK-0677.
    1 context sentence
    Summary · context
    The aim of the current study was to investigate whether it could be detected in equine hair following oral administration of MK-0677 mesylate to a Thoroughbred racehorse.

    In this study, MK-677 (ibutamoren) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking MK-677 (ibutamoren).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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