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Study · Animal study (in vivo) · mouse · 2023

12 results

Nicotinamide Mononucleotide Attenuates LPS-Induced Acute Lung Injury With Anti-Inflammatory, Anti-Oxidative and Anti-Apoptotic Effects.

Tian Y, Zhu CL, Li P, Li HR, Liu Q, Deng XM, Wang JF

The Journal of surgical research5 Nov 2022Cited by 25 (Europe PMC)

PMID36347171 (opens in a new tab)DOI10.1016/j.jss.2022.09.030 (opens in a new tab)PepBankPUB-36347171
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

12 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced lung pathological damage versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced lung damage compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLung pathological damage
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced lung cell apoptosis versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced lung cell death compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLung cell apoptosis
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced BALF TNF-α versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced BALF TNF-α compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBALF TNF-α
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced BALF IL-1β versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced BALF IL-1β compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBALF IL-1β
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced BALF IL-6 versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced BALF IL-6 compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBALF IL-6
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced BALF total cells versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced BALF total cells compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBALF total cells
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN reduced BALF neutrophils versus LPS alone.

    In plain wordsIn mice with acute lung injury, NMN reduced BALF neutrophils compared with LPS alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBALF neutrophils
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Inflammation markers · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN attenuated the pathological damage and cell apoptosis in lung tissue, decreased the levels of TNF-α, IL-1β, and IL-6 in BALF, and reduced the number of total cells and neutrophils in BALF.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN attenuated the LPS-induced increase in lung dry-to-wet ratio.

    In plain wordsIn mice, NMN reduced the lung dry-to-wet ratio increase caused by LPS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLung dry-to-wet ratio
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Lung injury and fibrosis · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN attenuated the LPS-induced elevation of dry-to-wet ratio, MDA content, p38 MAPK and p65 NF-κB phosphorylation levels, and the SOD activity was increased by NMN treatment.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN attenuated the LPS-induced increase in lung MDA content.

    In plain wordsIn mice, NMN reduced the lung MDA increase caused by LPS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseLung MDA content
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN attenuated the LPS-induced elevation of dry-to-wet ratio, MDA content, p38 MAPK and p65 NF-κB phosphorylation levels, and the SOD activity was increased by NMN treatment.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  10. 10AnimalAnimal study (in vivo)Mechanism

    In mice, NMN attenuated LPS-induced p38 MAPK phosphorylation.

    In plain wordsIn mice, NMN reduced p38 MAPK phosphorylation caused by LPS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Decreasep38 MAPK phosphorylation
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN attenuated the LPS-induced elevation of dry-to-wet ratio, MDA content, p38 MAPK and p65 NF-κB phosphorylation levels, and the SOD activity was increased by NMN treatment.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  11. 11AnimalAnimal study (in vivo)Mechanism

    In mice, NMN attenuated LPS-induced p65 NF-κB phosphorylation.

    In plain wordsIn mice, NMN reduced p65 NF-κB phosphorylation caused by LPS.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Decreasep65 NF-κB phosphorylation
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Receptor activity and mechanism · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN attenuated the LPS-induced elevation of dry-to-wet ratio, MDA content, p38 MAPK and p65 NF-κB phosphorylation levels, and the SOD activity was increased by NMN treatment.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In mice with acute lung injury, NMN increased SOD activity.

    In plain wordsIn mice with acute lung injury, NMN increased SOD activity.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSOD activity
    Study

    mousen: not reported in source

    LPS-induced acute lung injury
    Comparator
    LPS group
    Outcome group
    Oxidative stress · Respiratory
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, NMN attenuated the LPS-induced elevation of dry-to-wet ratio, MDA content, p38 MAPK and p65 NF-κB phosphorylation levels, and the SOD activity was increased by NMN treatment.
    2 context sentences
    Summary · context
    The ALI mouse model was performed by injecting LPS intratracheally at a dose of 10 mg/kg in 50 μL saline.
    Summary · context
    In the ALI mouse model, NMN showed a significant therapeutic effect compared to the LPS group.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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