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Study · Animal study (in vivo) · mouse · 2023

6 results

NMN alleviates radiation-induced intestinal fibrosis by modulating gut microbiota.

Zhao X, Ji K, Zhang M, Huang H, Wang F, Liu Y, Liu Q

International journal of radiation biology16 Nov 2022Cited by 22 (Europe PMC)

PMID36343364 (opens in a new tab)DOI10.1080/09553002.2023.2145029 (opens in a new tab)PepBankPUB-36343364
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In irradiated mice, NMN alleviated intestinal fibrosis.

    In plain wordsIn mice exposed to radiation, NMN reduced intestinal fibrosis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseIntestinal fibrosis
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    Long-term NMN supplementation alleviated intestinal fibrosis, and reshaped the composition and function of gut microbiota dysregulated by ionizing radiation (IR).
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN reshaped dysregulated gut microbiota composition.

    In plain wordsIn mice exposed to radiation, NMN changed the disrupted gut microbiota composition.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedGut microbiota composition
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    Long-term NMN supplementation alleviated intestinal fibrosis, and reshaped the composition and function of gut microbiota dysregulated by ionizing radiation (IR).
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN reshaped dysregulated gut microbiota function.

    In plain wordsIn mice exposed to radiation, NMN changed the disrupted gut microbiota function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Direction not reportedGut microbiota function
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    Long-term NMN supplementation alleviated intestinal fibrosis, and reshaped the composition and function of gut microbiota dysregulated by ionizing radiation (IR).
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, NMN increased Akkermansia muciniphila abundance.

    In plain wordsIn mice exposed to radiation, Akkermansia muciniphila was more abundant after NMN treatment.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAkkermansia muciniphila abundance
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    In addition, Akkermansia muciniphila, a promising probiotic, and metabolism-related pathways, such as Biosynthesis of other secondary metabolites and Amino acid metabolism, were more abundant after NMN treatment in irradiated mice.
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, secondary metabolite biosynthesis pathways were more abundant after NMN treatment.

    In plain wordsIn mice exposed to radiation, secondary metabolite biosynthesis pathways were more abundant after NMN treatment.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSecondary metabolite biosynthesis pathways
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    In addition, Akkermansia muciniphila, a promising probiotic, and metabolism-related pathways, such as Biosynthesis of other secondary metabolites and Amino acid metabolism, were more abundant after NMN treatment in irradiated mice.
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In irradiated mice, amino acid metabolism pathways were more abundant after NMN treatment.

    In plain wordsIn mice exposed to radiation, amino acid metabolism pathways were more abundant after NMN treatment.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAmino acid metabolism pathways
    Study

    mousen: not reported in source

    irradiated C57BL/6J mice
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    300 mg/kg/day · drinking waterAs given in this study (mouse).

    Source sentences

    Summary
    In addition, Akkermansia muciniphila, a promising probiotic, and metabolism-related pathways, such as Biosynthesis of other secondary metabolites and Amino acid metabolism, were more abundant after NMN treatment in irradiated mice.
    1 context sentence
    Summary · context
    C57BL/6J mice received 15 Gy abdominal irradiation and NMN (300 mg/kg/day) supplement in drinking water.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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