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Study · In vitro (cells) · common carp · 2023

3 results

Molecular cloning, tissue distribution, and pharmacologic function of melanocortin-3 receptor in common carp (Cyprinus carpio).

Du YY, Yao MX, Yu HX, Mo HL, Yang QY, Yu JJ, Wang LX, Zhou JS, Li Y

General and comparative endocrinology3 Nov 2022Cited by 5 (Europe PMC)

PMID36336108 (opens in a new tab)DOI10.1016/j.ygcen.2022.114149 (opens in a new tab)PepBankPUB-36336108
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In reporter assays of common carp Mc3r, NDP-MSH activated the cAMP signaling pathway, as did ACTH (1-24), α-MSH and β-MSH, with different potencies.

    In plain wordsIn lab tests with carp receptor cells, NDP-MSH switched on the cAMP signal, as did three other ligands.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreasecAMP signaling activation via common carp Mc3r
    Study

    common carpn: not reported in source

    Luciferase reporter assays of common carp Mc3r
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The luciferase reporter systems showed that four ligands, ACTH (1-24), α-MSH, β-MSH, and NDP-MSH, were able to activate the cAMP and MAPK/ERK signaling pathways downstream of ccMc3r with different potencies.
    1 context sentence
    Summary · context
    In this study, we cloned the coding sequence (CDS) of common carp Mc3r (ccMc3r), examined its tissue expression profile, and investigated the function of this receptor in mediating downstream signaling pathways.
  2. 02LabIn vitro (cells)Activity measurement

    In reporter assays of common carp Mc3r, NDP-MSH activated the MAPK/ERK signaling pathway, as did ACTH (1-24), α-MSH and β-MSH, with different potencies.

    In plain wordsIn lab tests with carp receptor cells, NDP-MSH switched on the MAPK/ERK signal, as did three other ligands.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    IncreaseMAPK/ERK signaling activation via common carp Mc3r
    Study

    common carpn: not reported in source

    Luciferase reporter assays of common carp Mc3r
    Outcome group
    Receptor activity and mechanism · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The luciferase reporter systems showed that four ligands, ACTH (1-24), α-MSH, β-MSH, and NDP-MSH, were able to activate the cAMP and MAPK/ERK signaling pathways downstream of ccMc3r with different potencies.
    1 context sentence
    Summary · context
    In this study, we cloned the coding sequence (CDS) of common carp Mc3r (ccMc3r), examined its tissue expression profile, and investigated the function of this receptor in mediating downstream signaling pathways.
  3. 03LabIn vitro (cells)Activity measurement

    In reporter assays of common carp Mc3r, NDP-MSH and the three other agonists inhibited TNF-α-induced NF-κB signaling.

    In plain wordsIn lab tests with carp receptor cells, NDP-MSH and three other agonists reduced an inflammation signal triggered by TNF-α.

    Peptide
    Melanotan I (afamelanotide)
    Outcome
    DecreaseInhibition of TNF-α-induced NF-κB signaling
    Study

    common carpn: not reported in source

    Luciferase reporter assays of common carp Mc3r
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, we found that the four agonists were able to inhibit TNF-α-induced NF-κB signaling in approximately the same order of potency as cAMP signaling activation.
    2 context sentences
    Summary · context
    The luciferase reporter systems showed that four ligands, ACTH (1-24), α-MSH, β-MSH, and NDP-MSH, were able to activate the cAMP and MAPK/ERK signaling pathways downstream of ccMc3r with different potencies.
    Summary · context
    In this study, we cloned the coding sequence (CDS) of common carp Mc3r (ccMc3r), examined its tissue expression profile, and investigated the function of this receptor in mediating downstream signaling pathways.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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