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Study · Animal study (in vivo) · rat and mouse · 2023

6 results

Gut microbiota-derived nicotinamide mononucleotide alleviates acute pancreatitis by activating pancreatic SIRT3 signalling.

Liu LW, Xie Y, Li GQ, Zhang T, Sui YH, Zhao ZJ, Zhang YY, Yang WB, Geng XL, Xue DB, Chen H, Wang YW and 5 more

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Lu TQ, Shang LR, Li ZB, Li L, Sun B

British journal of pharmacology4 Dec 2022Cited by 52 (Europe PMC)

PMID36321732 (opens in a new tab)DOI10.1111/bph.15980 (opens in a new tab)PepBankPUB-36321732
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In acute pancreatitis models, NMN reduced mitochondrial dysfunction.

    In plain wordsIn rats and mice with acute pancreatitis, NMN reduced mitochondrial dysfunction.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMitochondrial dysfunction
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Mitochondrial function · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration mitigated AP-mediated mitochondrial dysfunction, oxidative damage and inflammation by increasing pancreatic NAD+ levels.
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In acute pancreatitis models, NMN reduced oxidative damage.

    In plain wordsIn rats and mice with acute pancreatitis, NMN reduced oxidative damage.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseOxidative damage
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration mitigated AP-mediated mitochondrial dysfunction, oxidative damage and inflammation by increasing pancreatic NAD+ levels.
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In acute pancreatitis models, NMN reduced inflammation.

    In plain wordsIn rats and mice with acute pancreatitis, NMN reduced inflammation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseInflammation
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration mitigated AP-mediated mitochondrial dysfunction, oxidative damage and inflammation by increasing pancreatic NAD+ levels.
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In acute pancreatitis models, NMN increased pancreatic NAD levels.

    In plain wordsIn rats and mice with acute pancreatitis, NMN increased pancreatic NAD levels.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreasePancreatic NAD levels
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN administration mitigated AP-mediated mitochondrial dysfunction, oxidative damage and inflammation by increasing pancreatic NAD+ levels.
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05AnimalEndogenous levelAnimal study (in vivo)Other

    In acute pancreatitis models, normobiotic FMT increased NAD-associated metabolites, particularly NMN.

    In plain wordsIn rats and mice, normobiotic FMT increased natural NAD-associated metabolites, particularly NMN.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNMN levels after FMT
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Normobiotic FMT induced higher levels of NAD+ (nicotinamide adenine dinucleotide)-associated metabolites, particularly nicotinamide mononucleotide (NMN).
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.

    This result measures the body's own NMN (nicotinamide mononucleotide). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 06AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Mechanism

    In acute pancreatitis models, FMT-mediated NMN metabolism activated the SIRT3-PRDX5 pathway.

    In plain wordsIn rats and mice with acute pancreatitis, FMT-mediated NMN metabolism activated the SIRT3-PRDX5 pathway.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseSIRT3-PRDX5 activation
    Study

    rats and micen: not reported in source

    acute pancreatitis
    Outcome group
    Receptor activity and mechanism · Gastrointestinal

    Source sentences

    Summary
    Importantly, normobiotic FMT-mediated NMN metabolism induced SIRT3-PRDX5 pathway activation during AP.
    1 context sentence
    Summary · context
    AP rat and mouse models were established by administration of caerulein or sodium taurocholate in vivo.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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