Light-Activated Gold-Selenium Core-Shell Nanocomposites with NIR-II Photoacoustic Imaging Performances for Heart-Targeted Repair.

Sun Y, Zhang P, Li Y, Hou Y, Yin C, Wang Z, Liao Z, Fu X, Li M, Fan C, Sun D, Cheng L

ACS nano20 Oct 2022Cited by 44 (Europe PMC)

PMID36264835DOI10.1021/acsnano.2c07311PepBankPUB-36264835

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study12

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone12

In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Elamipretide (SS-31).

01AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia-reperfusion injury, administration of the nanocomposites dramatically improved myocardial function.
In plain wordsIn rats with heart injury, SS31-modified nanoparticles improved heart function.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMyocardial function
Study
ratn: not reported in source
rat myocardial ischemia-reperfusion injury
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
The in vivo AS-I/S NCs administration dramatically improved myocardial functions and angiogenesis and inhibited myocardial fibrosis through inhibiting myocardial apoptosis and oxidative damage in MI/RI of rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483508
02AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia-reperfusion injury, administration of the nanocomposites improved angiogenesis.
In plain wordsIn rats with heart injury, SS31-modified nanoparticles improved new blood vessel growth.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseAngiogenesis
Study
ratn: not reported in source
rat myocardial ischemia-reperfusion injury
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
The in vivo AS-I/S NCs administration dramatically improved myocardial functions and angiogenesis and inhibited myocardial fibrosis through inhibiting myocardial apoptosis and oxidative damage in MI/RI of rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483509
03AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Efficacy outcome
In rats with myocardial ischemia-reperfusion injury, administration of the nanocomposites inhibited myocardial fibrosis.
In plain wordsIn rats with heart injury, SS31-modified nanoparticles reduced scarring of heart tissue.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMyocardial fibrosis
Study
ratn: not reported in source
rat myocardial ischemia-reperfusion injury
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
The in vivo AS-I/S NCs administration dramatically improved myocardial functions and angiogenesis and inhibited myocardial fibrosis through inhibiting myocardial apoptosis and oxidative damage in MI/RI of rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483510
04AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Mechanism
In rats with myocardial ischemia-reperfusion injury, the nanocomposites inhibited myocardial apoptosis and oxidative damage.
In plain wordsIn rats with heart injury, SS31-modified nanoparticles reduced heart cell death and oxidative damage.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMyocardial apoptosis and oxidative damage
Study
ratn: not reported in source
rat myocardial ischemia-reperfusion injury
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
The in vivo AS-I/S NCs administration dramatically improved myocardial functions and angiogenesis and inhibited myocardial fibrosis through inhibiting myocardial apoptosis and oxidative damage in MI/RI of rats.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483511
05AnimalNot a test of Elamipretide (SS-31) aloneAnimal study (in vivo)Safety outcome
In rats, the nanocomposites showed good safety and biocompatibility in vivo.
In plain wordsIn rats, SS31-modified nanoparticles showed good safety and biocompatibility.
Peptide
Elamipretide (SS-31)
Outcome
No significant changeSafety and biocompatibility in vivo
Study
ratn: not reported in source
rat myocardial ischemia-reperfusion injury
Outcome group
Adverse events · Whole body
Source sentences
Summary
Importantly, the AS-I/S NCs showed good safety and biocompatibility in vivo.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483512
06LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Efficacy outcome
In H9c2 cells, SS31- and IMTP-modified gold-selenium nanocomposites inhibited cardiotoxicity induced by oxygen-glucose deprivation-recovery.
In plain wordsIn cells, SS31-modified nanoparticles reduced heart-cell damage caused by oxygen and glucose loss.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseOGD/R-induced cardiotoxicity in H9c2 cells
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Heart function · Cardiovascular
Source sentences
Summary
significantly inhibited oxygen-glucose deprivation-recovery (OGD/R)-induced cardiotoxicity of H9c2 cells by inhibiting the depletion of mitochondrial membrane potential (MMP) and restoring ATP synthase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483501
07LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In H9c2 cells, SS31- and IMTP-modified nanocomposites inhibited the depletion of mitochondrial membrane potential after oxygen-glucose deprivation-recovery.
In plain wordsIn cells, SS31-modified nanoparticles prevented the loss of mitochondrial membrane potential.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseMitochondrial membrane potential
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
by inhibiting the depletion of mitochondrial membrane potential (MMP) and restoring ATP synthase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483502
08LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In H9c2 cells, SS31- and IMTP-modified nanocomposites restored ATP synthase activity after oxygen-glucose deprivation-recovery.
In plain wordsIn cells, SS31-modified nanoparticles restored the activity of ATP synthase.
Peptide
Elamipretide (SS-31)
Outcome
IncreaseATP synthase activity
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
restoring ATP synthase activity.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483503
09LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In OGD/R-treated H9c2 cells, SS31-modified nanocomposites achieved mitochondria-targeted inhibition of reactive oxygen species.
In plain wordsIn cells, SS31-modified nanoparticles lowered reactive oxygen species inside mitochondria.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseMitochondrial reactive oxygen species
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Furthermore, the AS-I/S NCs after SS31 modification achieved mitochondria-targeted inhibition of reactive oxygen species (ROS) and subsequently attenuated oxidative damage in OGD/R-treated H9c2 cells by inhibition of apoptosis and oxidative damage, regulation of MAPKs and PI3K/AKT pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483504
10LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In OGD/R-treated H9c2 cells, SS31-modified nanocomposites inhibited apoptosis.
In plain wordsIn cells, SS31-modified nanoparticles reduced programmed cell death.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseApoptosis
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Furthermore, the AS-I/S NCs after SS31 modification achieved mitochondria-targeted inhibition of reactive oxygen species (ROS) and subsequently attenuated oxidative damage in OGD/R-treated H9c2 cells by inhibition of apoptosis and oxidative damage, regulation of MAPKs and PI3K/AKT pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483505
11LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In OGD/R-treated H9c2 cells, SS31-modified nanocomposites attenuated oxidative damage.
In plain wordsIn cells, SS31-modified nanoparticles reduced oxidative damage.
Peptide
Elamipretide (SS-31)
Outcome
DecreaseOxidative damage
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Mitochondrial function · Cardiovascular
Source sentences
Summary
Furthermore, the AS-I/S NCs after SS31 modification achieved mitochondria-targeted inhibition of reactive oxygen species (ROS) and subsequently attenuated oxidative damage in OGD/R-treated H9c2 cells by inhibition of apoptosis and oxidative damage, regulation of MAPKs and PI3K/AKT pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483506
12LabNot a test of Elamipretide (SS-31) aloneIn vitro (cells)Mechanism
In OGD/R-treated H9c2 cells, SS31-modified nanocomposites regulated the MAPKs and PI3K/AKT pathways; the direction is not stated.
In plain wordsIn cells, SS31-modified nanoparticles changed signalling pathways called MAPKs and PI3K/AKT.
Peptide
Elamipretide (SS-31)
Outcome
Direction not reportedMAPKs and PI3K/AKT pathways
Study
n: not reported in source
H9c2 cells with oxygen-glucose deprivation-recovery
Outcome group
Receptor activity and mechanism · Cardiovascular
Source sentences
Summary
Furthermore, the AS-I/S NCs after SS31 modification achieved mitochondria-targeted inhibition of reactive oxygen species (ROS) and subsequently attenuated oxidative damage in OGD/R-treated H9c2 cells by inhibition of apoptosis and oxidative damage, regulation of MAPKs and PI3K/AKT pathways.
1 context sentence(design, population, supporting numbers)
Summary · context
Herein, gold-selenium core-shell nanostructures (AS-I/S NCs) with good near-infrared (NIR)-II photoacoustic imaging were designed for MI/RI treatment.
In this study, Elamipretide (SS-31) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Elamipretide (SS-31).
Report a problemFND-3626483507

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 1
9 Oct 2026, 02:47 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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