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Study · Measured the body's own peptide · 2022

6 results

Associations between serum mitokine levels and outcomes in stable COPD: an observational prospective study.

Amado CA, Martín-Audera P, Agüero J, Lavín BA, Guerra AR, Muñoz P, Berja A, Casanova C, García-Unzueta M

Scientific reports15 Oct 2022Cited by 11 (Europe PMC)

PMID36243733 (opens in a new tab)PMCIDPMC9569360 (opens in a new tab)DOI10.1038/s41598-022-21757-5 (opens in a new tab)PepBankPUB-36243733
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Summary

Mitokines (Humanin (HN), GDF15 and FGF21) are produced as a result of mitochondrial dysfunction and may have major roles in chronic inflammation, malnutrition and exercise capacity in people with COPD. Except for GDF15, studies on this subject are lacking. A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled. We assessed their serum mitokine levels and clinical characteristics at baseline. We recorded moderate and severe exacerbation for the next 12 months. Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group. High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859-23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991-0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181-2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357-8.740, p = 0.009). High GDF15 levels were associated with HRE (OR 3.028, 95% CI 1.134-8.083, p = 0.027), 6MWD (OR 0.995, 95% CI 0.990-0.999, p = 0.017) and predicted desaturation in 6MWT (OR 3.999, 95% CI 1.487-10.757, p = 0.006). High FGF21 levels were associated with HRE (OR 2.144, 95% CI 1.000-4.600, p = 0.05), and predicted future severe exacerbation (HR 4.217, 95% CI 1.459-12.193, p = 0.008). The mitokine levels were higher in patients with COPD than smokers without COPD, and were associated with important clinical outcomes such as exercise capacity and COPD exacerbation. Among the mitokines, HN showed the strongest association with COPD and may serve as a future risk biomarker in this disease.Trial registation NCT04449419.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured6

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In patients with stable COPD, baseline serum humanin was higher than in smokers without COPD.

    In plain wordsIn people with stable COPD, the body's own humanin level in blood was higher than in smokers without COPD.

    Peptide
    Humanin
    Outcome
    IncreaseSerum humanin level in COPD versus smokers without COPD
    Study

    n = 214

    Comparator
    Smokers without COPD
    Outcome group
    Endogenous peptide levels · Respiratory

    Source sentences

    Summary
    Baseline serum HN (p = 0.037) and GDF-15 (p = 0.013) levels were higher in the COPD group.
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In patients with stable COPD, a high serum humanin level was independently associated with a high risk of exacerbation.

    In plain wordsIn people with COPD, a high level of the body's own humanin was linked to a high risk of flare-ups.

    Peptide
    Humanin
    Outcome
    IncreaseHigh serum humanin and risk of exacerbation
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Respiratory

    Measurements

    OR
    2.798 ratio
    high risk of exacerbation

    Source sentences

    Summary
    High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011)
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyOther

    In patients with stable COPD, a high serum humanin level was independently associated with malnutrition.

    In plain wordsIn people with COPD, a high level of the body's own humanin was linked to malnutrition.

    Peptide
    Humanin
    Outcome
    IncreaseHigh serum humanin and malnutrition
    Study

    n: not reported in source

    Outcome group
    Body composition · Respiratory

    Measurements

    OR
    6.645 ratio
    malnutrition

    Source sentences

    Summary
    High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859-23.749, p = 0.004)
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyOther

    In patients with stable COPD, a high serum humanin level was independently associated with 6MWD (OR 0.995).

    In plain wordsIn people with COPD, a high level of the body's own humanin was linked to walking distance in a 6-minute test.

    Peptide
    Humanin
    Outcome
    Not applicableHigh serum humanin and 6-minute walk distance (6MWD)
    Study

    n: not reported in source

    Outcome group
    Exercise and physical function · Respiratory

    Measurements

    OR
    0.995 ratio
    6MWD

    Source sentences

    Summary
    High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859-23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991-0.999, p = 0.008)
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyOther

    In patients with stable COPD, a high serum humanin level was independently associated with future moderate exacerbations.

    In plain wordsIn people with COPD, a high level of the body's own humanin was linked to later moderate flare-ups.

    Peptide
    Humanin
    Outcome
    IncreaseHigh serum humanin and future moderate exacerbation
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Respiratory

    Measurements

    HR
    1.826 ratio
    future moderate exacerbation

    Source sentences

    Summary
    High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859-23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991-0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181-2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357-8.740, p = 0.009).
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  6. 06HumanEndogenous levelObservational studyOther

    In patients with stable COPD, a high serum humanin level was independently associated with future severe exacerbations.

    In plain wordsIn people with COPD, a high level of the body's own humanin was linked to later severe flare-ups.

    Peptide
    Humanin
    Outcome
    IncreaseHigh serum humanin and future severe exacerbation
    Study

    n: not reported in source

    Outcome group
    Endogenous peptide levels · Respiratory

    Measurements

    HR
    3.445 ratio
    future severe exacerbation

    Source sentences

    Summary
    High HN levels were independently associated with a high risk of exacerbation (HRE) (OR 2.798, 95% CI 1.266-6.187, p = 0.011), malnutrition (OR 6.645, 95% CI 1.859-23.749, p = 0.004), and 6MWD (OR 0.995, 95% CI 0.991-0.999, p = 0.008), and future moderate (HR 1.826, 95% CI 1.181-2.822, p = 0.007) and severe exacerbations (HR 3.445, 95% CI 1.357-8.740, p = 0.009).
    1 context sentence
    Summary · context
    A total of 165 patients with stable COPD and 49 smokers without COPD were enrolled.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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