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Study · Animal study (in vivo) · mouse · 2022

13 results

Pentadecapeptide BPC 157 efficiently reduces radiation-induced liver injury and lipid accumulation through Kruppel-like factor 4 upregulation both in vivo and in vitro.

Huang BS, Huang SC, Chen FH, Chang Y, Mei HF, Huang HY, Chen WY, Pang JS

Life sciences10 Oct 2022Cited by 25 (Europe PMC)

PMID36228773 (opens in a new tab)DOI10.1016/j.lfs.2022.121072 (opens in a new tab)PepBankPUB-36228773
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study13

13 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with radiation-induced acute liver injury, oral BPC‑157 decreased plasma AST and ALT levels.

    In plain wordsIn mice given radiation, BPC‑157 by mouth lowered blood levels of two liver enzymes, AST and ALT.

    Peptide
    BPC-157
    Outcome
    DecreasePlasma AST and ALT levels
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 was firstly demonstrated to reduce RILD by decreasing plasma levels of AST and ALT, and inhibiting hydropic degeneration of liver.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with radiation-induced acute liver injury, oral BPC‑157 inhibited hydropic degeneration of the liver.

    In plain wordsIn mice given radiation, BPC‑157 by mouth reduced a type of liver cell swelling called hydropic degeneration.

    Peptide
    BPC-157
    Outcome
    DecreaseHydropic degeneration of liver
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 was firstly demonstrated to reduce RILD by decreasing plasma levels of AST and ALT, and inhibiting hydropic degeneration of liver.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with radiation-induced acute liver injury, oral BPC‑157 significantly decreased radiation-induced cell apoptosis in liver.

    In plain wordsIn mice given radiation, BPC‑157 by mouth reduced radiation-caused liver cell death.

    Peptide
    BPC-157
    Outcome
    DecreaseRadiation-induced cell apoptosis
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Organ injury · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with radiation-induced acute liver injury, oral BPC‑157 increased PCNA expression in liver.

    In plain wordsIn mice given radiation, BPC‑157 by mouth raised the level of the protein PCNA in the liver.

    Peptide
    BPC-157
    Outcome
    IncreasePCNA expression
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with radiation-induced acute liver injury, oral BPC‑157 promoted KLF4 expression in liver.

    In plain wordsIn mice given radiation, BPC‑157 by mouth raised the level of the protein KLF4 in the liver.

    Peptide
    BPC-157
    Outcome
    IncreaseKLF4 expression
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with radiation-induced acute liver injury, oral BPC‑157 decreased radiation-induced hepatic lipid accumulation.

    In plain wordsIn mice given radiation, BPC‑157 by mouth reduced fat build-up in the liver.

    Peptide
    BPC-157
    Outcome
    DecreaseRadiation-induced hepatic lipid accumulation
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In mice with radiation-induced acute liver injury, oral BPC‑157 decreased radiation-induced HIF-2α expression in liver.

    In plain wordsIn mice given radiation, BPC‑157 by mouth lowered the level of the protein HIF-2α in the liver.

    Peptide
    BPC-157
    Outcome
    DecreaseHIF-2α expression
    Study

    Micen: not reported in source

    Acute radiation-induced liver injury (single 12 Gy dose)
    Comparator
    Irradiated mice without BPC 157
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated · OralAs given in this study (Mice).

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    Mice were irradiated with a single dose of 12 Gy to induce acute liver injury with or without oral BPC 157.
  8. 08LabIn vitro (cells)Activity measurement

    In rat liver clone 9 cells, BPC‑157 significantly decreased radiation-induced cell apoptosis.

    In plain wordsIn cells from rat liver, BPC‑157 reduced radiation-caused cell death.

    Peptide
    BPC-157
    Outcome
    DecreaseRadiation-induced cell apoptosis
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Organ injury · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
  9. 09LabIn vitro (cells)Mechanism

    In rat liver clone 9 cells, BPC‑157 increased PCNA expression.

    In plain wordsIn cells from rat liver, BPC‑157 raised the level of the protein PCNA.

    Peptide
    BPC-157
    Outcome
    IncreasePCNA expression
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
  10. 10LabIn vitro (cells)Mechanism

    In rat liver clone 9 cells, BPC‑157 promoted KLF4 expression.

    In plain wordsIn cells from rat liver, BPC‑157 raised the level of the protein KLF4.

    Peptide
    BPC-157
    Outcome
    IncreaseKLF4 expression
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
  11. 11LabIn vitro (cells)Activity measurement

    In rat liver clone 9 cells, BPC‑157 decreased radiation-induced lipid accumulation.

    In plain wordsIn cells from rat liver, BPC‑157 reduced radiation-caused fat build-up.

    Peptide
    BPC-157
    Outcome
    DecreaseRadiation-induced hepatic lipid accumulation
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
  12. 12LabIn vitro (cells)Mechanism

    In rat liver clone 9 cells, BPC‑157 decreased radiation-induced HIF-2α expression.

    In plain wordsIn cells from rat liver, BPC‑157 lowered the level of the protein HIF-2α.

    Peptide
    BPC-157
    Outcome
    DecreaseHIF-2α expression
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 significantly decreased radiation-induced cell apoptosis, increased PCNA expression, promoted the expression of KLF4, decreased the radiation-induced hepatic lipid accumulation and HIF-2α expression both in mice liver and in clone 9 liver cells.
    1 context sentence
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
  13. 13LabIn vitro (cells)Mechanism

    In rat liver clone 9 cells, KLF4 knockdown (siRNA) abolished the protective effect of BPC‑157 on radiation-induced apoptosis and lipid accumulation, indicating that the effect was mediated by KLF4.

    In plain wordsIn cells from rat liver, knocking down KLF4 removed the protective effect of BPC‑157 against radiation-caused cell death and fat build-up.

    Peptide
    BPC-157
    Outcome
    Not applicableProtective effect of BPC 157 after KLF4 knockdown
    Study

    Ratn: not reported in source

    Rat liver clone 9 cells (radiation-induced injury)
    Outcome group
    Receptor activity and mechanism · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The knockdown of KLF4 abolished the protective effect of BPC 157 on radiation-induced apoptosis and lipid accumulation in clone 9 liver cells, indicating that the protective effect of BPC 157 was mediated by KLF4 in liver cells.
    2 context sentences
    Summary · context
    In vitro rat liver clone 9 cells and in vivo liver tissues were harvested for MTT assay, TUNEL assay, lipid staining, polypoid cell counts, Western blotting of caspase-3, PCNA, KLF-4 and HIF-2α, and immunocytochemistry for PCNA, KLF-4 and HIF-2α.
    Summary · context
    SiRNAs were used to knockdown KLF-4.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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