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Study · Animal study (in vivo) · macaca mulatta · 2022

7 results

Effects of Combined Treatment with Compounds Affecting Mitochondria on Physiological Parameters in Old Monkey.

Klots IN, Gvozdik TE, Shamsutdinova OA, Mukhametzyanova EI, Keburiya VV, Gvaramiya IA, Karal-Ogly DD

Bulletin of experimental biology and medicine1 Sept 2022Cited by 1 (Europe PMC)

PMID36214985 (opens in a new tab)DOI10.1007/s10517-022-05606-z (opens in a new tab)PepBankPUB-36214985
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN did not improve the hematological parameters improved by MitoQ.

    In plain wordsIn monkeys, NMN did not improve the blood parameters that MitoQ improved.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeHematological parameters
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Blood biochemical markers · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of MitoQ, but not NMN improved some hematological and biochemical parameters, shifting them to the values of young animals.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN did not improve the biochemical parameters improved by MitoQ.

    In plain wordsIn monkeys, NMN did not improve the biochemical parameters that MitoQ improved.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBiochemical parameters
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Blood biochemical markers · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The use of MitoQ, but not NMN improved some hematological and biochemical parameters, shifting them to the values of young animals.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, adding NMN offered no clear advantages over MitoQ alone.

    In plain wordsIn monkeys, adding NMN offered no clear advantages over MitoQ alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeOverall combination advantage
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Comparator
    MitoQ alone
    Outcome group
    Aging markers · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Combined use of the two drugs had no clear advantages over MitoQ alone.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.

Studies that did not test the peptide alone4

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 04AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN and MitoQ treatment sequences did not change body weight.

    In plain wordsIn monkeys, treatment sequences involving NMN and MitoQ did not change body weight.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBody weight
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Body weight · Whole body

    Source sentences

    Summary
    The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 05AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN and MitoQ treatment sequences did not change body temperature.

    In plain wordsIn monkeys, treatment sequences involving NMN and MitoQ did not change body temperature.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeBody temperature
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Body temperature · Whole body

    Source sentences

    Summary
    The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 06AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN and MitoQ treatment sequences did not change hemostasis.

    In plain wordsIn monkeys, treatment sequences involving NMN and MitoQ did not change blood clotting.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeHemostasis
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Bleeding and clotting · Whole body

    Source sentences

    Summary
    The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  4. 07AnimalNot a test of NMN (nicotinamide mononucleotide) aloneAnimal study (in vivo)Efficacy outcome

    In male rhesus monkeys, NMN and MitoQ treatment sequences did not change ECG.

    In plain wordsIn monkeys, treatment sequences involving NMN and MitoQ did not change ECG results.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    No significant changeECG
    Study

    Macaca mulattan: not reported in source

    Male rhesus monkeys
    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    The above treatment did not lead to changes in the body weight and body temperature, hemostasis, and ECG.
    2 context sentences
    Summary · context
    The effect of NAD+ (in the form of its precursor nicotinamide mononucleotide, NMN) and antioxidant MitoQ specifically affecting mitochondria was studied on male rhesus monkeys (Macaca mulatta).
    Summary · context
    The first group of animals initially received only NMN, the second group received only MitoQ, and then both groups received both drugs simultaneously.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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