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Study · Animal study (in vivo) · rat · 2022

5 results

Difelikefalin, a peripherally restricted KOR (kappa opioid receptor) agonist, produces diuresis through a central KOR pathway.

Meariman JK, Sutphen JC, Gao J, Mercante DE, Kapusta DR

Pharmacological research3 Oct 2022Cited by 9 (Europe PMC)

PMID36202183 (opens in a new tab)DOI10.1016/j.phrs.2022.106470 (opens in a new tab)PepBankPUB-36202183
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Activity measurement

    In rats, difelikefalin significantly increased urine output.

    In plain wordsIn rats, difelikefalin significantly increased urine output.

    Peptide
    Difelikefalin
    Outcome
    IncreaseUrine output
    Study

    ratn: not reported in source

    Conscious Sprague-Dawley rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · 90 min observationAs given in this study (rat).

    Source sentences

    Summary
    Difelikefalin produced a significant increase in urine output, and significant decrease in urinary sodium and potassium excretion, urine osmolality, and MAP.
    2 context sentences
    Summary · context
    Following catheterization, conscious Sprague-Dawley rats were infused i.v. with isotonic saline and pretreated with norBNI centrally via an intracerebroventricular (ICV) cannula or peripherally via an intravenous catheter.
    Summary · context
    After stabilization, difelikefalin or nalfurafine was administered i.v. and urine output, heart rate and mean arterial pressure (MAP) were recorded for 90 min.
  2. 02AnimalAnimal study (in vivo)Activity measurement

    In rats, difelikefalin significantly reduced urinary sodium excretion.

    In plain wordsIn rats, difelikefalin significantly reduced sodium loss in urine.

    Peptide
    Difelikefalin
    Outcome
    DecreaseUrinary sodium excretion
    Study

    ratn: not reported in source

    Conscious Sprague-Dawley rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · 90 min observationAs given in this study (rat).

    Source sentences

    Summary
    Difelikefalin produced a significant increase in urine output, and significant decrease in urinary sodium and potassium excretion, urine osmolality, and MAP.
    2 context sentences
    Summary · context
    Following catheterization, conscious Sprague-Dawley rats were infused i.v. with isotonic saline and pretreated with norBNI centrally via an intracerebroventricular (ICV) cannula or peripherally via an intravenous catheter.
    Summary · context
    After stabilization, difelikefalin or nalfurafine was administered i.v. and urine output, heart rate and mean arterial pressure (MAP) were recorded for 90 min.
  3. 03AnimalAnimal study (in vivo)Activity measurement

    In rats, difelikefalin significantly reduced urinary potassium excretion.

    In plain wordsIn rats, difelikefalin significantly reduced potassium loss in urine.

    Peptide
    Difelikefalin
    Outcome
    DecreaseUrinary potassium excretion
    Study

    ratn: not reported in source

    Conscious Sprague-Dawley rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · 90 min observationAs given in this study (rat).

    Source sentences

    Summary
    Difelikefalin produced a significant increase in urine output, and significant decrease in urinary sodium and potassium excretion, urine osmolality, and MAP.
    2 context sentences
    Summary · context
    Following catheterization, conscious Sprague-Dawley rats were infused i.v. with isotonic saline and pretreated with norBNI centrally via an intracerebroventricular (ICV) cannula or peripherally via an intravenous catheter.
    Summary · context
    After stabilization, difelikefalin or nalfurafine was administered i.v. and urine output, heart rate and mean arterial pressure (MAP) were recorded for 90 min.
  4. 04AnimalAnimal study (in vivo)Activity measurement

    In rats, difelikefalin significantly reduced urine osmolality.

    In plain wordsIn rats, difelikefalin significantly reduced urine concentration.

    Peptide
    Difelikefalin
    Outcome
    DecreaseUrine osmolality
    Study

    ratn: not reported in source

    Conscious Sprague-Dawley rats
    Outcome group
    Kidney function · Kidney and urinary
    Studied dose
    Dose not stated · intravenous · 90 min observationAs given in this study (rat).

    Source sentences

    Summary
    Difelikefalin produced a significant increase in urine output, and significant decrease in urinary sodium and potassium excretion, urine osmolality, and MAP.
    2 context sentences
    Summary · context
    Following catheterization, conscious Sprague-Dawley rats were infused i.v. with isotonic saline and pretreated with norBNI centrally via an intracerebroventricular (ICV) cannula or peripherally via an intravenous catheter.
    Summary · context
    After stabilization, difelikefalin or nalfurafine was administered i.v. and urine output, heart rate and mean arterial pressure (MAP) were recorded for 90 min.
  5. 05AnimalAnimal study (in vivo)Activity measurement

    In rats, difelikefalin significantly reduced mean arterial pressure.

    In plain wordsIn rats, difelikefalin significantly reduced mean arterial blood pressure.

    Peptide
    Difelikefalin
    Outcome
    DecreaseMean arterial pressure
    Study

    ratn: not reported in source

    Conscious Sprague-Dawley rats
    Outcome group
    Blood pressure · Cardiovascular
    Studied dose
    Dose not stated · intravenous · 90 min observationAs given in this study (rat).

    Source sentences

    Summary
    Difelikefalin produced a significant increase in urine output, and significant decrease in urinary sodium and potassium excretion, urine osmolality, and MAP.
    2 context sentences
    Summary · context
    Following catheterization, conscious Sprague-Dawley rats were infused i.v. with isotonic saline and pretreated with norBNI centrally via an intracerebroventricular (ICV) cannula or peripherally via an intravenous catheter.
    Summary · context
    After stabilization, difelikefalin or nalfurafine was administered i.v. and urine output, heart rate and mean arterial pressure (MAP) were recorded for 90 min.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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