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Study · Animal study (in vivo) · horse · 2022

5 results

Endocrine and ovarian responses to combined estradiol benzoate-sulpiride in seasonally anovulatory mares treated with kisspeptin.

Bailey VN, Sones JL, Camp CM, Gomes VCL, Oberhaus EL

Animal reproduction science30 Sept 2022Cited by 4 (Europe PMC)

PMID36201980 (opens in a new tab)DOI10.1016/j.anireprosci.2022.107087 (opens in a new tab)PepBankPUB-36201980
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In anestrous mares given estradiol benzoate and sulpiride, seven Kp10-treated mares responded compared with 4 saline-treated mares.

    In plain wordsIn anestrous mares, more mares given kisspeptin responded with ovarian activity than mares given saline.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMares responding with early ovarian activity
    Study

    horsen = 18

    seasonally anovulatory anestrous mares
    Comparator
    Saline with estradiol benzoate and sulpiride
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 μg/hour · osmotic minipumpAs given in this study (horse).

    Measurements

    Responding mares
    4 mares
    saline

    Source sentences

    Summary
    Seven Kp10-treated mares responded compared to only 4 saline-treated mares.
    2 context sentences
    Summary · context
    Eighteen anestrous mares were blocked by breed, body condition, and age before random assignment to treatment or control.
    Summary · context
    All mares received 50 mg EB before receiving osmotic minipumps containing either saline (n = 9) or Kp10 (50 μg/hour; n = 9) one day later.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In anestrous mares, the time from sulpiride treatment to ovarian response was shorter with Kp10 than with saline.

    In plain wordsIn mares, ovarian response came sooner with kisspeptin than with saline.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseDays from sulpiride treatment to ovarian response
    Study

    horsen = 18

    seasonally anovulatory anestrous mares
    Comparator
    Saline with estradiol benzoate and sulpiride
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 μg/hour · osmotic minipumpAs given in this study (horse).

    Measurements

    Days to ovarian response
    13.7 d
    Kp10
    Days to ovarian response
    35.9 d
    saline

    Source sentences

    Summary
    Mean days from sulpiride treatment to ovarian response was less in Kp10-treated mares (13.7 ± 1.1 d, P ≤ 0.01) compared to saline-treated mares (35.9 ± 7.8 d).
    2 context sentences
    Summary · context
    Eighteen anestrous mares were blocked by breed, body condition, and age before random assignment to treatment or control.
    Summary · context
    All mares received 50 mg EB before receiving osmotic minipumps containing either saline (n = 9) or Kp10 (50 μg/hour; n = 9) one day later.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In anestrous mares, plasma prolactin after sulpiride was higher with Kp10 than with saline.

    In plain wordsIn mares, prolactin was higher with kisspeptin than with saline after sulpiride.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma prolactin
    Study

    horsen = 18

    seasonally anovulatory anestrous mares
    Comparator
    Saline with estradiol benzoate and sulpiride
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    50 μg/hour · osmotic minipumpAs given in this study (horse).

    Source sentences

    Summary
    Plasma prolactin increased (P < 0.001) in response to sulpiride in all mares; however, prolactin was higher (P < 0.05) in Kp10-treated mares.
    2 context sentences
    Summary · context
    Eighteen anestrous mares were blocked by breed, body condition, and age before random assignment to treatment or control.
    Summary · context
    All mares received 50 mg EB before receiving osmotic minipumps containing either saline (n = 9) or Kp10 (50 μg/hour; n = 9) one day later.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In anestrous mares, plasma LH after sulpiride was greater with Kp10 than with saline.

    In plain wordsIn mares, luteinizing hormone was higher with kisspeptin than with saline after sulpiride.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH
    Study

    horsen = 18

    seasonally anovulatory anestrous mares
    Comparator
    Saline with estradiol benzoate and sulpiride
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 μg/hour · osmotic minipumpAs given in this study (horse).

    Source sentences

    Summary
    Plasma LH increased in all mares beginning 5 days after sulpiride but was greater (P < 0.0001) in Kp10-treated mares.
    2 context sentences
    Summary · context
    Eighteen anestrous mares were blocked by breed, body condition, and age before random assignment to treatment or control.
    Summary · context
    All mares received 50 mg EB before receiving osmotic minipumps containing either saline (n = 9) or Kp10 (50 μg/hour; n = 9) one day later.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In anestrous mares, plasma FSH did not differ between Kp10 and saline groups.

    In plain wordsIn mares, follicle-stimulating hormone did not differ between the kisspeptin and saline groups.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changePlasma FSH
    Study

    horsen = 18

    seasonally anovulatory anestrous mares
    Comparator
    Saline with estradiol benzoate and sulpiride
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    50 μg/hour · osmotic minipumpAs given in this study (horse).

    Source sentences

    Summary
    Plasma FSH concentrations did not differ between groups.
    2 context sentences
    Summary · context
    Eighteen anestrous mares were blocked by breed, body condition, and age before random assignment to treatment or control.
    Summary · context
    All mares received 50 mg EB before receiving osmotic minipumps containing either saline (n = 9) or Kp10 (50 μg/hour; n = 9) one day later.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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