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Study · Not a test of the peptide alone · 2023

2 results

Thymosin β4 and prothymosin α promote cardiac regeneration post-ischaemic injury in mice.

Gladka MM, Johansen AKZ, van Kampen SJ, Peters MMC, Molenaar B, Versteeg D, Kooijman L, Zentilin L, Giacca M, van Rooij E

Cardiovascular research1 May 2023Cited by 17 (Europe PMC)

PMID36125329 (opens in a new tab)DOI10.1093/cvr/cvac155 (opens in a new tab)PepBankPUB-36125329
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice after myocardial ischaemia, delivery of a gene combination of TMSB4 and PTMA gave a permissive environment for cardiomyocyte proliferation.

    In plain wordsIn mice after a heart attack, delivering two genes together (thymosin beta‑4 and prothymosin alpha) helped heart muscle cells to multiply.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCardiomyocyte proliferation with TMSB4 and PTMA gene delivery
    Study

    mousen: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    a combination of thymosin beta 4 (TMSB4) and prothymosin alpha (PTMA) provide a permissive environment for cardiomyocyte proliferation
    1 context sentence
    Summary · context
    Here, we demonstrate increased 5-ethynyl-2'deoxyuridine incorporation in cardiomyocytes 3 days post-myocardial infarction in mice.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice after myocardial ischaemia, delivery of a gene combination of TMSB4 and PTMA attenuated cardiac dysfunction.

    In plain wordsIn mice after a heart attack, delivering two genes together (thymosin beta‑4 and prothymosin alpha) lessened heart dysfunction.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseCardiac dysfunction with TMSB4 and PTMA gene delivery
    Study

    mousen: not reported in source

    Outcome group
    Heart function · Cardiovascular

    Source sentences

    Summary
    a combination of thymosin beta 4 (TMSB4) and prothymosin alpha (PTMA) provide a permissive environment for cardiomyocyte proliferation and thereby attenuated cardiac dysfunction
    1 context sentence
    Summary · context
    Here, we demonstrate increased 5-ethynyl-2'deoxyuridine incorporation in cardiomyocytes 3 days post-myocardial infarction in mice.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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