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Study · Animal study (in vivo) · mouse · 2022

11 results

Treatment of inflammatory bowel disease: Potential effect of NMN on intestinal barrier and gut microbiota.

Huang P, Wang X, Wang S, Wu Z, Zhou Z, Shao G, Ren C, Kuang M, Zhou Y, Jiang A, Tang W, Miao J, Qian X, Gong A, Xu M

Current research in food science5 Sept 2022Cited by 35 (Europe PMC)

PMID36105890 (opens in a new tab)PMCIDPMC9464647 (opens in a new tab)DOI10.1016/j.crfs.2022.08.011 (opens in a new tab)PepBankPUB-36105890
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN improved inflamed intestinal morphology.

    In plain wordsIn mice with colitis, NMN improved inflamed intestinal structure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseIntestinal morphology
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After NMN treatment, we observed improved morphology of inflamed intestines, slightly restored length of colon, improved barrier function and reduced proinflammatory factors expression in serum.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN slightly restored colon length.

    In plain wordsIn mice with colitis, NMN slightly restored colon length.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseColon length
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After NMN treatment, we observed improved morphology of inflamed intestines, slightly restored length of colon, improved barrier function and reduced proinflammatory factors expression in serum.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN improved intestinal barrier function.

    In plain wordsIn mice with colitis, NMN improved intestinal barrier function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseBarrier function
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After NMN treatment, we observed improved morphology of inflamed intestines, slightly restored length of colon, improved barrier function and reduced proinflammatory factors expression in serum.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN reduced serum proinflammatory factor expression.

    In plain wordsIn mice with colitis, NMN reduced inflammatory factors in serum.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseSerum proinflammatory factors
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    After NMN treatment, we observed improved morphology of inflamed intestines, slightly restored length of colon, improved barrier function and reduced proinflammatory factors expression in serum.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN significantly altered intestinal flora composition and abundance.

    In plain wordsIn mice with colitis, NMN changed gut bacteria composition and abundance.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    MixedIntestinal flora composition and abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Also, significant alterations in the composition and abundance of intestinal flora in IBD mice were found.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN increased Firmicutes abundance.

    In plain wordsIn mice with colitis, NMN increased Firmicutes bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseFirmicutes abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN increased Verrucomicrobia abundance.

    In plain wordsIn mice with colitis, NMN increased Verrucomicrobia bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseVerrucomicrobia abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN increased Akkermansia abundance.

    In plain wordsIn mice with colitis, NMN increased Akkermansia bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAkkermansia abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN increased Lactobacillus abundance.

    In plain wordsIn mice with colitis, NMN increased Lactobacillus bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseLactobacillus abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN decreased Bacteroidetes abundance.

    In plain wordsIn mice with colitis, NMN decreased Bacteroidetes bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseBacteroidetes abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In colitis mice, NMN decreased unclassified Muribaculaceae abundance.

    In plain wordsIn mice with colitis, NMN decreased unclassified Muribaculaceae bacteria.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMuribaculaceae abundance
    Study

    mousen: not reported in source

    DSS colitis
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The abundance of Firmicutes, Verrucomicrobia, Akkermansia and Lactobacillus, considered as beneficial bacteria, increased, while Bacteroidetes and Muribaculaceae unclassifiably decreased.
    1 context sentence
    Summary · context
    In this study, we established experimental models of colitis by mixing drinking water of C57BL/6J mice with dextran sodium sulphate (DSS), and then fed them with the same concentration of NMN or at the same time.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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