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Study · Animal study (in vivo) · mouse · 2022

6 results

SS-31 as a Mitochondrial Protectant in the Treatment of Tendinopathy: Evaluation in a Murine Supraspinatus Tendinopathy Model.

Zhang X, Bowen E, Zhang M, Szeto HH, Deng XH, Rodeo SA

The Journal of bone and joint surgery. American volume18 Aug 2022Cited by 21 (Europe PMC)

PMID35984013 (opens in a new tab)DOI10.2106/jbjs.21.01449 (opens in a new tab)PepBankPUB-35984013
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with supraspinatus tendinopathy, SS‑31 treatment partially reversed the impingement-induced decrease in failure force.

    In plain wordsIn mice with shoulder tendon damage, SS‑31 partly restored the strength lost after impingement.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseTendon failure force
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Failure force decreased after impingement, compared with the intact tendon, and the decrease was partially reversed after clip removal, SS-31 treatment, and the 2 treatments combined.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with supraspinatus tendinopathy, stiffness showed the same pattern as failure force: a decrease after impingement that treatment, including SS‑31, partly reversed.

    In plain wordsIn mice with shoulder tendon damage, tendon stiffness fell after impingement and was partly restored after treatment including SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseTendon stiffness
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Failure force decreased after impingement, compared with the intact tendon, and the decrease was partially reversed after clip removal, SS-31 treatment, and the 2 treatments combined. A similar pattern was observed for stiffness.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with supraspinatus tendinopathy, the higher modified Bonar scores after impingement were partially reversed after all treatments, including SS‑31.

    In plain wordsIn mice with shoulder tendon damage, tendon tissue structure partly returned toward normal after treatment including SS‑31.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseHistological tendon morphology (modified Bonar score)
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Tendon and ligament healing · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Histological analysis demonstrated higher modified Bonar scores in the impingement groups; however, the changes in tendon morphology were partially reversed following all treatments, especially the combined treatment.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with supraspinatus tendinopathy, mitochondrial structure and number became more normal after clip removal and/or SS‑31 treatment.

    In plain wordsIn mice with shoulder tendon damage, tendon mitochondria looked more normal after SS‑31 treatment and clip removal.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondrial structure and number
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Decreased mitochondrial number and altered organization and density of cristae were observed in the impingement groups. Mitochondrial structure and number became more normal, with improvement in morphology of the cristae, after clip removal and/or SS-31 treatment.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with supraspinatus tendinopathy, SOD activity decreased after impingement and increased significantly again after treatment, especially in the combined treatment group.

    In plain wordsIn mice with shoulder tendon damage, an antioxidant enzyme activity that fell after impingement rose again after treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseSuperoxide dismutase (SOD) activity
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    SOD activity decreased after impingement, compared with the control group, then increased significantly again after treatment, especially in the combined treatment group.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)
  6. 06AnimalAnimal study (in vivo)Mechanism

    In mice with supraspinatus tendinopathy, mitochondria-related gene expression decreased with impingement and increased again after treatment.

    In plain wordsIn mice with shoulder tendon damage, mitochondria-related gene activity fell after impingement and rose again after treatment.

    Peptide
    Elamipretide (SS-31)
    Outcome
    IncreaseMitochondria-related gene expression
    Study

    mousen: not reported in source

    Murine supraspinatus tendinopathy model (subacromial impingement)
    Comparator
    Impingement without treatment
    Outcome group
    Mitochondrial function · Musculoskeletal
    Studied dose
    5 mg/kg/d · 4 weeksAs given in this study (mouse).

    Source sentences

    Summary
    Mitochondria-related gene expression decreased in the impingement groups and increased again after treatment.
    1 context sentence
    Summary · context
    including 4 weeks of SS-31 treatment (5 mg/kg/d)

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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