[Effect and mechanism of thymosin beta 4 on spinal cord-derived neural stem /progenitor cell injury induced by oxidative stress].

Li HW, Zhang HH

Zhongguo gu shang = China journal of orthopaedics and traumatology1 Aug 2022Cited by 1 (Europe PMC)

PMID35979771DOI10.12200/j.issn.1003-0034.2022.08.012PepBankPUB-35979771

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

13 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly increased cell viability compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 raised cell viability compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseNSPC cell viability
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977102
02LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly increased Ca2+ concentration compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 raised the Ca2+ concentration compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseIntracellular Ca2+ concentration
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977103
03LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased lactate dehydrogenase release compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 reduced a marker of cell damage compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseLDH release
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977104
04LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased apoptosis compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 reduced cell death compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseApoptosis of NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977105
05LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased reactive oxygen species production compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 lowered reactive oxygen species compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseReactive oxygen species production
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977106
06LabIn vitro (cells)Efficacy outcome
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased production of pro-inflammatory cytokines compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 lowered inflammatory cytokines compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePro-inflammatory cytokine production
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Inflammation markers · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977107
07LabIn vitro (cells)Mechanism
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased TLR4 protein expression compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 lowered TLR4 protein compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTLR4 protein expression
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977108
08LabIn vitro (cells)Mechanism
In H2O2-injured rat neural stem/progenitor cells, Tβ4 significantly decreased MyD88 protein expression compared with the H2O2 group.
In plain wordsIn rat cells injured by oxidative stress, Tβ4 lowered MyD88 protein compared with injured cells without Tβ4.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseMyD88 protein expression
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
H2O2 group
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
1, 2.5 and 5 μg/mlAs given in this study (rat).
Source sentences
Summary
Compared with H₂O₂ group, the cell viability and Ca2+ concentration was significantly increased, release of LDH and apoptosis were significantly decreased, production of ROS and pro-inflammatory cytokines were significantly decreased, and the expression levels of TLR4 and MyD88…
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977109
09LabIn vitro (cells)Efficacy outcome
In MyD88-overexpressing rat neural stem/progenitor cells treated with H2O2, Tβ4 treatment increased cell viability.
In plain wordsIn rat cells with extra MyD88 and oxidative injury, Tβ4 treatment raised cell viability.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCell viability in MyD88-overexpressing NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After overexpression of MyD88, cell viability, SOD activity and GSH content of NSPCs decreased, LDH release and apoptosis increased significantly (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977110
10LabIn vitro (cells)Efficacy outcome
In MyD88-overexpressing rat neural stem/progenitor cells treated with H2O2, Tβ4 treatment increased superoxide dismutase activity.
In plain wordsIn rat cells with extra MyD88 and oxidative injury, Tβ4 treatment raised superoxide dismutase activity.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseSOD activity in MyD88-overexpressing NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After overexpression of MyD88, cell viability, SOD activity and GSH content of NSPCs decreased, LDH release and apoptosis increased significantly (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977111
11LabIn vitro (cells)Efficacy outcome
In MyD88-overexpressing rat neural stem/progenitor cells treated with H2O2, Tβ4 treatment increased glutathione content.
In plain wordsIn rat cells with extra MyD88 and oxidative injury, Tβ4 treatment raised glutathione content.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseGSH content in MyD88-overexpressing NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After overexpression of MyD88, cell viability, SOD activity and GSH content of NSPCs decreased, LDH release and apoptosis increased significantly (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977112
12LabIn vitro (cells)Efficacy outcome
In MyD88-overexpressing rat neural stem/progenitor cells treated with H2O2, Tβ4 treatment decreased lactate dehydrogenase release.
In plain wordsIn rat cells with extra MyD88 and oxidative injury, Tβ4 treatment reduced a marker of cell damage.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseLDH release in MyD88-overexpressing NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After overexpression of MyD88, cell viability, SOD activity and GSH content of NSPCs decreased, LDH release and apoptosis increased significantly (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977113
13LabIn vitro (cells)Efficacy outcome
In MyD88-overexpressing rat neural stem/progenitor cells treated with H2O2, Tβ4 treatment decreased apoptosis.
In plain wordsIn rat cells with extra MyD88 and oxidative injury, Tβ4 treatment reduced cell death.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseApoptosis in MyD88-overexpressing NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
After overexpression of MyD88, cell viability, SOD activity and GSH content of NSPCs decreased, LDH release and apoptosis increased significantly (PP<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
Report a problemFND-3597977114

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

14LabEndogenous levelIn vitro (cells)Mechanism
In rat spinal cord-derived neural stem/progenitor cells, H2O2 injury decreased the expression of the body's own Tβ4.
In plain wordsIn rat cells, oxidative injury lowered the body's own Tβ4 level.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTβ4 expression in H2O2-injured NSPCs
Study
ratn: not reported in source
spinal cord-derived NSPCs injured by H2O2
Comparator
Untreated NSPCs
Outcome group
Neuroprotection · Nervous system and cognition
Source sentences
Summary
The expression of Tβ4 was decreased in H₂O₂ injured NSPCs(P<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
NSPCs were isolated from Sprague-Dawley (SD) adult male rats, and divided into control group (untreated NSPCs cells), H₂O₂ group (NSPCs cells damaged by 500 μM H₂O₂), Tβ4 -3 groups (NSPCs were treated with 1, 2.5, 5 μg/ml Tβ4 on the basis of H₂O…
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3597977101

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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