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Study · Animal study (in vivo) · mouse · 2022

5 results

Revolutionalizing the age old conventional treatment of psoriasis: An animal based comparative study between methylprednisolone and different doses of a novel anti-oxidant humanin analogue (HNG).

Salahuddin Z, Rafi A, Muhammad H, Aftab U, Akhtar T, Zafar MS, Shahzad M

International immunopharmacology22 Jul 2022Cited by 2 (Europe PMC)

PMID35978518 (opens in a new tab)DOI10.1016/j.intimp.2022.108990 (opens in a new tab)PepBankPUB-35978518
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with imiquimod-induced psoriasis-like skin, intraperitoneal S14-G HNG significantly improved histology.

    In plain wordsIn mice with a psoriasis-like skin condition, S14-G HNG injections improved skin histology.

    Peptide
    Humanin
    Outcome
    Direction not reportedSkin histology
    Study

    mousen: not reported in source

    imiquimod-induced psoriasis-like condition in BALB/c mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Significant improvement was seen on histology, PASI scoring, protein expression and oxidative stress by the use of intraperitoneal injections of S14-G HNG and the results were comparable to those obtained through peritoneal injections of methylprednisolone.
    2 context sentences
    Summary · context
    Imiquimod 5% was used to induce Psoriasis like condition in mice, and the role of HNG was assessed through the histological examination, protein expressions and markers of oxidative stress.
    Summary · context
    Two doses (low and high) of HNG were used and results were compared with an established drug methylprednisolone.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with imiquimod-induced psoriasis-like skin, intraperitoneal S14-G HNG significantly improved the PASI score.

    In plain wordsIn mice with a psoriasis-like skin condition, S14-G HNG injections improved the PASI score.

    Peptide
    Humanin
    Outcome
    DecreasePASI score
    Study

    mousen: not reported in source

    imiquimod-induced psoriasis-like condition in BALB/c mice
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Significant improvement was seen on histology, PASI scoring, protein expression and oxidative stress by the use of intraperitoneal injections of S14-G HNG and the results were comparable to those obtained through peritoneal injections of methylprednisolone.
    2 context sentences
    Summary · context
    Imiquimod 5% was used to induce Psoriasis like condition in mice, and the role of HNG was assessed through the histological examination, protein expressions and markers of oxidative stress.
    Summary · context
    Two doses (low and high) of HNG were used and results were compared with an established drug methylprednisolone.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with imiquimod-induced psoriasis-like skin, intraperitoneal S14-G HNG significantly improved protein expression.

    In plain wordsIn mice with a psoriasis-like skin condition, S14-G HNG injections improved protein expression.

    Peptide
    Humanin
    Outcome
    Direction not reportedProtein expression
    Study

    mousen: not reported in source

    imiquimod-induced psoriasis-like condition in BALB/c mice
    Outcome group
    Inflammation markers · Skin and wound
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Significant improvement was seen on histology, PASI scoring, protein expression and oxidative stress by the use of intraperitoneal injections of S14-G HNG and the results were comparable to those obtained through peritoneal injections of methylprednisolone.
    2 context sentences
    Summary · context
    Imiquimod 5% was used to induce Psoriasis like condition in mice, and the role of HNG was assessed through the histological examination, protein expressions and markers of oxidative stress.
    Summary · context
    Two doses (low and high) of HNG were used and results were compared with an established drug methylprednisolone.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice with imiquimod-induced psoriasis-like skin, intraperitoneal S14-G HNG significantly improved oxidative stress.

    In plain wordsIn mice with a psoriasis-like skin condition, S14-G HNG injections improved oxidative stress.

    Peptide
    Humanin
    Outcome
    Direction not reportedOxidative stress markers
    Study

    mousen: not reported in source

    imiquimod-induced psoriasis-like condition in BALB/c mice
    Outcome group
    Oxidative stress · Skin and wound
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Significant improvement was seen on histology, PASI scoring, protein expression and oxidative stress by the use of intraperitoneal injections of S14-G HNG and the results were comparable to those obtained through peritoneal injections of methylprednisolone.
    2 context sentences
    Summary · context
    Imiquimod 5% was used to induce Psoriasis like condition in mice, and the role of HNG was assessed through the histological examination, protein expressions and markers of oxidative stress.
    Summary · context
    Two doses (low and high) of HNG were used and results were compared with an established drug methylprednisolone.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice with imiquimod-induced psoriasis-like skin, the S14-G HNG results were comparable to those of methylprednisolone.

    In plain wordsIn mice with a psoriasis-like skin condition, S14-G HNG results were comparable to methylprednisolone.

    Peptide
    Humanin
    Outcome
    No significant changeOverall response compared with methylprednisolone
    Study

    mousen: not reported in source

    imiquimod-induced psoriasis-like condition in BALB/c mice
    Comparator
    Methylprednisolone
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    Significant improvement was seen on histology, PASI scoring, protein expression and oxidative stress by the use of intraperitoneal injections of S14-G HNG and the results were comparable to those obtained through peritoneal injections of methylprednisolone.
    2 context sentences
    Summary · context
    Imiquimod 5% was used to induce Psoriasis like condition in mice, and the role of HNG was assessed through the histological examination, protein expressions and markers of oxidative stress.
    Summary · context
    Two doses (low and high) of HNG were used and results were compared with an established drug methylprednisolone.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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