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Study · Not a test of the peptide alone · 2022

3 results

Potential anti neuro-inflammatory effect of BioCen-128 in animal models of dementia.

Esquivel N, García Y, Menéndez R, García TE, Morales AR, Rodríguez C

Animal models and experimental medicine15 Aug 2022Cited by 1 (Europe PMC)

PMID35971614 (opens in a new tab)PMCIDPMC9434568 (opens in a new tab)DOI10.1002/ame2.12267 (opens in a new tab)PepBankPUB-35971614
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Summary

BackgroundBioCen-128 is a new active pharmaceutical ingredient composed of a specific bovine thymic fraction of a polypeptide nature. Positive results of similar thymus extracts have been shown to be effective in delaying the processes associated with aging, immunosenescence and Alzheimer's disease (AD), where the inflammation plays an important role. Because of the anti-inflammatory potential of BioCen-128, the aim of this study was to evaluate the granuloma model induced by a cotton wool implantation and the model induced by intracerebroventricular (ICV) administration of streptozotocin (STZ).MethodThe experiment was carried out using male OF-1cenp mice weighing 20 ± 2 g.ResultsMice administered BioCen-128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti-inflammatory effect. In the ICV model of STZ, the administration of BioCen-128 improved cognitive function.ConclusionThese responses suggested an anti-neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins. The results suggested that BioCen-128 could be used in the prevention and treatment of some diseases, for example AD, where neuroinflammation is one of the biological events that take place.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study3

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone3

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with cotton wool-induced granuloma, the thymic fraction BioCen-128 given by IP injection decreased the wet weight of the granuloma.

    In plain wordsIn mice, a thymus-derived extract reduced the wet weight of an induced inflammatory lump. The extract is not pure thymosin β4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGranuloma wet weight
    Study

    mousen: not reported in source

    cotton wool implantation granuloma
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Mice administered BioCen-128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti-inflammatory effect.
    2 context sentences
    Summary · context
    These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins.
    Summary · context
    The experiment was carried out using male OF-1cenp mice weighing 20 ± 2 g.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice with cotton wool-induced granuloma, the thymic fraction BioCen-128 given by IP injection decreased the dry weight of the granuloma.

    In plain wordsIn mice, a thymus-derived extract reduced the dry weight of an induced inflammatory lump. The extract is not pure thymosin β4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseGranuloma dry weight
    Study

    mousen: not reported in source

    cotton wool implantation granuloma
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    Mice administered BioCen-128 in via the IP route at 5, 10 and 20 mg/kg of corporal weigh showed a decrease in the wet and dry weights of the granuloma, providing evidence of a systemic anti-inflammatory effect.
    2 context sentences
    Summary · context
    These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins.
    Summary · context
    The experiment was carried out using male OF-1cenp mice weighing 20 ± 2 g.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In mice given intracerebroventricular streptozotocin, the thymic fraction BioCen-128 improved cognitive function.

    In plain wordsIn mice with induced memory problems, a thymus-derived extract improved cognitive function. The extract is not pure thymosin β4.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCognitive function in ICV STZ model
    Study

    mousen: not reported in source

    intracerebroventricular streptozotocin model
    Outcome group
    Cognition and memory · Nervous system and cognition

    Source sentences

    Summary
    In the ICV model of STZ, the administration of BioCen-128 improved cognitive function.
    2 context sentences
    Summary · context
    These responses suggested an anti-neuroinflammatory effect explainable by the action of thymosin β4 and thymosin alfa proteins.
    Summary · context
    The experiment was carried out using male OF-1cenp mice weighing 20 ± 2 g.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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