Skip to content

Study · In vitro (cells) · 2022

3 results

Transplantation of Astrocytic Mitochondria Modulates Neuronal Antioxidant Defense and Neuroplasticity and Promotes Functional Recovery after Intracerebral Hemorrhage.

Tashiro R, Bautista-Garrido J, Ozaki D, Sun G, Obertas L, Mobley AS, Kim GS, Aronowski J, Jung JE

The Journal of neuroscience : the official journal of the Society for Neuroscience7 Sept 2022Cited by 43 (Europe PMC)

PMID35970559 (opens in a new tab)PMCIDPMC9463988 (opens in a new tab)DOI10.1523/jneurosci.2222-21.2022 (opens in a new tab)PepBankPUB-35970559
Source linkPubMedAsk about this study
Jump to 3 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In cultured neurons under ICH-like injury, humanin simulated the effect of mitochondria transfer on neuronal Mn-SOD expression, which mitochondria restored.

    In plain wordsIn cultured neurons, humanin mimicked the effect of transferred mitochondria on the antioxidant enzyme Mn-SOD.

    Peptide
    Humanin
    Outcome
    IncreaseNeuronal Mn-SOD expression
    Study

    n: not reported in source

    cultured neurons with ICH-like injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that Mt genome-encoded small peptide humanin, which is normally abundant in Mt, could simulate Mt-transfer effect on neuronal Mn-SOD expression, oxidative stress, and neuroplasticity under ICH-like injury.
    1 context sentence
    Summary · context
    by restoring neuronal Mn-SOD levels while at the same time promoted neurite extension and upregulation of synaptogenesis-related gene expression.
  2. 02LabIn vitro (cells)Mechanism

    In cultured neurons under ICH-like injury, humanin simulated the effect of mitochondria transfer on oxidative stress, which mitochondria prevented.

    In plain wordsIn cultured neurons, humanin mimicked the effect of transferred mitochondria on oxidative stress.

    Peptide
    Humanin
    Outcome
    DecreaseNeuronal oxidative stress
    Study

    n: not reported in source

    cultured neurons with ICH-like injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that Mt genome-encoded small peptide humanin, which is normally abundant in Mt, could simulate Mt-transfer effect on neuronal Mn-SOD expression, oxidative stress, and neuroplasticity under ICH-like injury.
    1 context sentence
    Summary · context
    prevented reactive oxygen species-induced oxidative stress and neuronal death by restoring neuronal Mn-SOD levels while at the same time promoted neurite extension and upregulation of synaptogenesis-related gene expression.
  3. 03LabIn vitro (cells)Mechanism

    In cultured neurons under ICH-like injury, humanin simulated the effect of mitochondria transfer on neuroplasticity, which mitochondria promoted.

    In plain wordsIn cultured neurons, humanin mimicked the effect of transferred mitochondria on neuroplasticity.

    Peptide
    Humanin
    Outcome
    IncreaseNeuroplasticity
    Study

    n: not reported in source

    cultured neurons with ICH-like injury
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that Mt genome-encoded small peptide humanin, which is normally abundant in Mt, could simulate Mt-transfer effect on neuronal Mn-SOD expression, oxidative stress, and neuroplasticity under ICH-like injury.
    1 context sentence
    Summary · context
    promoted neurite extension and upregulation of synaptogenesis-related gene expression.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.