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Study · Animal study (in vivo) · rat (wistar) · 2022

21 results

Kisspeptin treatment improves fetal-placental development and blocks placental oxidative damage caused by maternal hypothyroidism in an experimental rat model.

Santos BR, Dos Anjos Cordeiro JM, Santos LC, Barbosa EM, Mendonça LD, Santos EO, de Macedo IO, de Lavor MSL, Szawka RE, Serakides R, Silva JF

Frontiers in endocrinology28 Jul 2022Cited by 12 (Europe PMC)

PMID35966095 (opens in a new tab)PMCIDPMC9365946 (opens in a new tab)DOI10.3389/fendo.2022.908240 (opens in a new tab)PepBankPUB-35966095
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Summary

Maternal hypothyroidism is associated with fetal growth restriction, placental dysfunction, and reduced kisspeptin/Kiss1R at the maternal-fetal interface. Kisspeptin affects trophoblastic migration and has antioxidant and immunomodulatory activities. This study aimed to evaluate the therapeutic potential of kisspeptin in the fetal-placental dysfunction of hypothyroid Wistar rats. Hypothyroidism was induced by daily administration of propylthiouracil. Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation. Feto-placental development, placental histomorphometry, and expression levels of growth factors (VEGF, PLGF, IGF1, IGF2, and GLUT1), hormonal (Dio2) and inflammatory mediators (TNFα, IL10, and IL6), markers of hypoxia (HIF1α) and oxidative damage (8-OHdG), antioxidant enzymes (SOD1, Cat, and GPx1), and endoplasmic reticulum stress mediators (ATF4, GRP78, and CHOP) were evaluated on day 18 of gestation. Daily treatment with Kp-10 increased free T3 and T4 levels and improved fetal weight. Both treatments reestablished the glycogen cell population in the junctional zone. Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1. Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism. However, in the labyrinth zone, this treatment restored the expression of VEGF and IL10 and reduced the GRP78 and CHOP immunostaining. These findings demonstrate that daily treatment with Kp-10 improves fetal development and placental morphology in hypothyroid rats, blocks placental oxidative damage, and increases the expression of growth factors and antioxidant enzymes in the placenta.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study21

21 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased free T3 levels.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised free T3 levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFree T3 level
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased free T3 and T4 levels and improved fetal weight.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased free T4 levels.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised free T4 levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFree T4 level
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Thyroid function · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased free T3 and T4 levels and improved fetal weight.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 improved fetal weight.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 improved fetal weight.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseFetal weight
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased free T3 and T4 levels and improved fetal weight.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, both kisspeptin‑10 regimens reestablished the glycogen cell population in the placental junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, both kisspeptin‑10 regimens restored a placental cell population.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseGlycogen cell population in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Both treatments reestablished the glycogen cell population in the junctional zone.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased placental Plgf gene expression.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental Plgf gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Plgf expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased placental Igf1 gene expression.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental Igf1 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Igf1 expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased placental Glut1 gene expression.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental Glut1 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Glut1 expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  8. 08AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 blocked the increase in placental 8-OHdG.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 blocked a rise in a placental DNA damage marker.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePlacental 8-OHdG (oxidative DNA damage)
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  9. 09AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased protein and/or mRNA expression of SOD1 in the placenta.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental SOD1 levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental SOD1 expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  10. 10AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased protein and/or mRNA expression of Cat in the placenta.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental Cat levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental Cat expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  11. 11AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 increased protein and/or mRNA expression of GPx1 in the placenta.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 raised placental GPx1 levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlacental GPx1 expression
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 increased the gene expression levels of Plgf, Igf1, and Glut1 in the placenta of hypothyroid animals, in addition to blocking the increase in 8-OHdG and increasing protein and/or mRNA expression levels of SOD1, Cat, and GPx1.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  12. 12AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the higher VEGF protein level in the junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the raised VEGF level in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeVEGF protein in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  13. 13AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the higher HIF1α protein level in the junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the raised HIF1α level in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeHIF1α protein in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  14. 14AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the higher IL10 protein level in the junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the raised IL10 level in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeIL10 protein in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  15. 15AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the higher GRP78 protein level in the junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the raised GRP78 level in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeGRP78 protein in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  16. 16AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the higher CHOP protein level in the junctional zone.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the raised CHOP level in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeCHOP protein in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  17. 17AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid pregnant rats, daily kisspeptin‑10 did not alter the lower Dio2 expression caused by hypothyroidism.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 did not change the lowered Dio2 gene activity.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeDio2 expression in the junctional zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Daily treatment with Kp-10 did not alter the higher protein expression levels of VEGF, HIF1α, IL10, GRP78, and CHOP caused by hypothyroidism in the junctional zone compared to control, nor the lower expression of Dio2 caused by hypothyroidism.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  18. 18AnimalAnimal study (in vivo)Efficacy outcome

    In the labyrinth zone of the placenta of hypothyroid rats, daily kisspeptin‑10 restored VEGF expression.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 restored VEGF levels in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedVEGF expression in the labyrinth zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in the labyrinth zone, this treatment restored the expression of VEGF and IL10 and reduced the GRP78 and CHOP immunostaining.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  19. 19AnimalAnimal study (in vivo)Efficacy outcome

    In the labyrinth zone of the placenta of hypothyroid rats, daily kisspeptin‑10 restored IL10 expression.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 restored IL10 levels in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    Direction not reportedIL10 expression in the labyrinth zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Inflammation markers · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in the labyrinth zone, this treatment restored the expression of VEGF and IL10 and reduced the GRP78 and CHOP immunostaining.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  20. 20AnimalAnimal study (in vivo)Efficacy outcome

    In the labyrinth zone of the placenta of hypothyroid rats, daily kisspeptin‑10 reduced GRP78 immunostaining.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 lowered GRP78 staining in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseGRP78 immunostaining in the labyrinth zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in the labyrinth zone, this treatment restored the expression of VEGF and IL10 and reduced the GRP78 and CHOP immunostaining.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.
  21. 21AnimalAnimal study (in vivo)Efficacy outcome

    In the labyrinth zone of the placenta of hypothyroid rats, daily kisspeptin‑10 reduced CHOP immunostaining.

    In plain wordsIn pregnant rats with an underactive thyroid, daily kisspeptin‑10 lowered CHOP staining in one placental zone.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCHOP immunostaining in the labyrinth zone
    Study

    rat (Wistar)n: not reported in source

    pregnant rats with propylthiouracil-induced hypothyroidism
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, in the labyrinth zone, this treatment restored the expression of VEGF and IL10 and reduced the GRP78 and CHOP immunostaining.
    2 context sentences
    Summary · context
    Hypothyroidism was induced by daily administration of propylthiouracil.
    Summary · context
    Kisspeptin-10 (Kp-10) treatment was performed every other day or daily beginning on day 8 of gestation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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