Skip to content

Study · Measured the body's own peptide · 2022

6 results

Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia.

Liao Y, Xiao N, Wang X, Dai S, Wang G

International immunopharmacology3 Aug 2022Cited by 12 (Europe PMC)

PMID35932611 (opens in a new tab)DOI10.1016/j.intimp.2022.109002 (opens in a new tab)PepBankPUB-35932611
Publisher pagePubMedAsk about this study
Jump to 6 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01AnimalEndogenous levelAnimal study (in vivo)Other

    In cell and mouse models of septicemia, expression of the body's own Tmsb4x was decreased.

    In plain wordsIn cell and mouse models of septicemia, the body's own Tmsb4x level was lower.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseTmsb4x expression in septicemia
    Study

    mousen: not reported in source

    mouse septicemia model and LPS-stimulated mononuclear cells
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    Cell and animal models demonstrated decreased Tmsb4x expression in the setting of septicemia
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 02LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the septicemia cell model, decreased Tmsb4x expression led to an increased inflammatory response.

    In plain wordsIn cells, lower natural Tmsb4x was linked to a stronger inflammatory response.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseInflammatory response with decreased Tmsb4x
    Study

    n: not reported in source

    LPS-stimulated mononuclear cells with Tmsb4x silencing
    Outcome group
    Inflammation markers · Immune and inflammation

    Source sentences

    Summary
    which led to increased inflammatory response
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 03LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the septicemia cell model, decreased Tmsb4x expression led to a reduced proportion of dendritic cells.

    In plain wordsIn cells, lower natural Tmsb4x was linked to a smaller share of dendritic immune cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseProportion of dendritic cells with decreased Tmsb4x
    Study

    n: not reported in source

    LPS-stimulated mononuclear cells with Tmsb4x silencing
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    reduced proportion of DCs
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 04LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the septicemia cell model, decreased Tmsb4x expression was accompanied by inhibited mononuclear cell viability.

    In plain wordsIn cells, lower natural Tmsb4x was linked to less viable immune cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseMononuclear cell viability with decreased Tmsb4x
    Study

    n: not reported in source

    LPS-stimulated mononuclear cells with Tmsb4x silencing
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    inhibited mononuclear cell viability
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 05LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the septicemia cell model, decreased Tmsb4x expression was accompanied by promoted apoptosis of mononuclear cells.

    In plain wordsIn cells, lower natural Tmsb4x was linked to more immune cell death.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseMononuclear cell apoptosis with decreased Tmsb4x
    Study

    n: not reported in source

    LPS-stimulated mononuclear cells with Tmsb4x silencing
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    promoted apoptosis.
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 06LabNot a test of Thymosin beta-4 (human) aloneIn vitro (cells)Mechanism

    In the septicemia cell model, restoration of Tmsb4x expression facilitated differentiation of mononuclear cells into dendritic cells.

    In plain wordsIn cells, restoring Tmsb4x helped immune cells develop into dendritic cells.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseDifferentiation of mononuclear cells into dendritic cells after Tmsb4x restoration
    Study

    n: not reported in source

    LPS-stimulated mononuclear cells with Tmsb4x re-expression
    Outcome group
    Immune response · Immune and inflammation

    Source sentences

    Summary
    However, restoration of Tmsb4x facilitated the differentiation of mononuclear cells into DCs.
    2 context sentences
    Summary · context
    Herein, we investigated the effects of Tmsb4x on the mononuclear cells to affect immune responses during septicemia.
    Summary · context
    A cell model was constructed with mononuclear cells through lipopolysaccharide stimulation.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

PepBank is a research reference. Talk to a doctor before you use any peptide.