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Study · Measured the body's own peptide · 2022

1 result

Salivary Proteomics Reveals Significant Changes in Relation to Alzheimer's Disease and Aging.

Contini C, Serrao S, Manconi B, Olianas A, Iavarone F, Bizzarro A, Masullo C, Castagnola M, Messana I, Diaz G, Cabras T

Journal of Alzheimer's disease : JAD1 Jan 2022Cited by 14 (Europe PMC)

PMID35912740 (opens in a new tab)DOI10.3233/jad-220246 (opens in a new tab)PepBankPUB-35912740
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

No result from this study comes from a test of the peptide.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In saliva, the level of the body's own thymosin β4 was highest in people with Alzheimer's disease, compared with healthy adult and elderly controls.

    In plain wordsNatural thymosin β4 in saliva was highest in people with Alzheimer's disease, linked to the disease in this study.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseSalivary thymosin β4 level in Alzheimer's disease
    Study

    n: not reported in source

    Comparator
    Healthy adult and elderly controls
    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    AD subjects exhibited the highest levels of α-defensins, thymosin β4, cystatin B, S100A8 and A9.
    1 context sentence
    Summary · context
    Salivary proteomic data of healthy controls under-70 (adults) and over-70 (elderly) years old, and over-70 AD patients, obtained by liquid chromatography/mass spectrometry, were analyzed by multiple Mann-Whitney test, Kendall correlation, and Random-Forest (RF) analysis.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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