In male Wistar rats with cadmium chloride testicular damage, kisspeptin at 20 and 40 nmol/rat significantly restored reproductive features.
In plain wordsIn rats with cadmium-induced testicle damage, kisspeptin restored reproductive features compared with untreated damaged rats.
- Peptide
- Kisspeptin-54 (metastin)
- Outcome
- IncreaseReproductive features after cadmium chloride damage
- Study
ratn: not reported in source
male Wistar rats with cadmium chloride-induced testicular degeneration- Comparator
- Cadmium chloride without kisspeptin (positive control)
- Outcome group
- Sex hormones and fertility · Reproductive and sexual health
- Studied dose
- 20 and 40 nmol/rat · subcutaneous · 42 daysAs given in this study (rat).
Source sentences
The results of the present study confirmed that cadmium chloride affected the male testes and sperm parameters, while the administration of kisspeptin at doses of 20 and 40 nmol/rat (twice a week) by SC injection showed a significant effect in restoring the reproduction feature and histology of the…
1 context sentence(design, population, supporting numbers)
This study aimed to investigate the effect of kisspeptin on testicular degeneration syndrome induced by cadmium chloride in male Wistar rats and identify the best concentration of kisspeptin to cure this syndrome.