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Study · Not a test of the peptide alone · 2022

5 results

ROS-responsive hydrogel coating modified titanium promotes vascularization and osteointegration of bone defects by orchestrating immunomodulation.

Li X, Xu K, He Y, Tao B, Li K, Lin C, Hu J, Wu J, Wu Y, Liu S, Liu P, Wang H, Cai K

Biomaterials18 Jul 2022Cited by 89 (Europe PMC)

PMID35870263 (opens in a new tab)DOI10.1016/j.biomaterials.2022.121683 (opens in a new tab)PepBankPUB-35870263
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone5

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 01AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In bone defects, the Tβ4-loaded implant regulated the polarization of macrophages, as stated by the authors.

    In plain wordsIn bone defects, an implant coated with a gel that releases Tβ4 changed how immune cells called macrophages were polarized, the authors say.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableMacrophage polarization
    Study

    n: not reported in source

    bone defect with Tβ4 hydrogel-coated titanium implant
    Outcome group
    Immune response · Musculoskeletal

    Source sentences

    Summary
    by regulating the polarization of macrophages
    1 context sentence
    Summary · context
    Here, a novel functionalized titanium which loaded with thymosin β4 (Tβ4) and covered by a hydrogel coating was designed and evaluated.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  2. 02AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In bone defects, the Tβ4-loaded implant reduced fibrosis formation around the implant interface, as stated by the authors.

    In plain wordsIn bone defects, an implant coated with a gel that releases Tβ4 reduced scar tissue around the implant, the authors say.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    DecreaseFibrosis at the implant interface
    Study

    n: not reported in source

    bone defect with Tβ4 hydrogel-coated titanium implant
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    reducing the fibrosis formation around the implant interface
    1 context sentence
    Summary · context
    Here, a novel functionalized titanium which loaded with thymosin β4 (Tβ4) and covered by a hydrogel coating was designed and evaluated.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  3. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In bone defects, the Tβ4-loaded implant promoted vascularization, as stated by the authors.

    In plain wordsIn bone defects, an implant coated with a gel that releases Tβ4 increased new blood vessel growth, the authors say.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseVascularization of bone defects
    Study

    n: not reported in source

    bone defect with Tβ4 hydrogel-coated titanium implant
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    promoting vascularization and osteointegration of bone defects.
    1 context sentence
    Summary · context
    Here, a novel functionalized titanium which loaded with thymosin β4 (Tβ4) and covered by a hydrogel coating was designed and evaluated.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  4. 04AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome

    In bone defects, the Tβ4-loaded implant promoted osteointegration, as stated by the authors.

    In plain wordsIn bone defects, an implant coated with a gel that releases Tβ4 increased the bonding of the implant with bone, the authors say.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseOsteointegration of bone defects
    Study

    n: not reported in source

    bone defect with Tβ4 hydrogel-coated titanium implant
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    promoting vascularization and osteointegration of bone defects.
    1 context sentence
    Summary · context
    Here, a novel functionalized titanium which loaded with thymosin β4 (Tβ4) and covered by a hydrogel coating was designed and evaluated.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

  5. 05LabNot a test of Thymosin beta-4 (human) aloneOther designOther

    A hydrogel-coated titanium implant was designed to release Tβ4 in response to the immune reaction of bone healing, using the ROS response of borate bonds.

    In plain wordsIn lab design work, a coated titanium implant was built to release thymosin β4 when the immune reaction of bone healing occurs.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableROS-responsive release of Tβ4 from the coating
    Study

    n: not reported in source

    ROS-responsive hydrogel coating on titanium
    Outcome group
    Bone and joint · Musculoskeletal

    Source sentences

    Summary
    the implant can release Tβ4 in response to the immune reaction of bone healing
    1 context sentence
    Summary · context
    Here, a novel functionalized titanium which loaded with thymosin β4 (Tβ4) and covered by a hydrogel coating was designed and evaluated.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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