Recombinant DTβ4-inspired porous 3D vascular graft enhanced antithrombogenicity and recruited circulating CD93⁺/CD34⁺ cells for endothelialization.

Xiao W, Chen W, Wang Y, Zhang C, Zhang X, Zhang S, Wu W

Science advances13 Jul 2022Cited by 21 (Europe PMC)

PMID35857526PMCIDPMC9278867DOI10.1126/sciadv.abn1958PepBankPUB-35857526

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Summary

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Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, vascular grafts patterned with dimeric thymosin β4 (DTβ4) contributed to a high patency rate.
In plain wordsIn rabbits, vascular grafts carrying a dimeric form of thymosin β4 stayed open at a high rate.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseGraft patency
Study
rabbitn: not reported in source
carotid artery graft
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · conjugated to implanted vascular graftAs given in this study (rabbit).
Source sentences
Summary
Furthermore, highly porous structures enabled 3D patterning of conjugated heparin-binding peptide, dimeric thymosin β4 (DTβ4), which played key roles in antiplatelets, fibrinogenesis inhibition, and recruiting circulating progenitor cells, thereafter contributed to high patency rate, and unprecedent…
1 context sentence(design, population, supporting numbers)
Summary · context
We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate.
Report a problemFND-3585752601
02AnimalAnimal study (in vivo)Efficacy outcome
In rabbits, grafts patterned with DTβ4 acquired carotid arterial regeneration.
In plain wordsIn rabbits, grafts carrying a dimeric form of thymosin β4 were followed by regrowth of the carotid artery.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCarotid arterial regeneration
Study
rabbitn: not reported in source
carotid artery graft
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · conjugated to implanted vascular graftAs given in this study (rabbit).
Source sentences
Summary
Furthermore, highly porous structures enabled 3D patterning of conjugated heparin-binding peptide, dimeric thymosin β4 (DTβ4), which played key roles in antiplatelets, fibrinogenesis inhibition, and recruiting circulating progenitor cells, thereafter contributed to high patency rate, and unprecedent…
1 context sentence(design, population, supporting numbers)
Summary · context
We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate.
Report a problemFND-3585752602
03AnimalAnimal study (in vivo)Efficacy outcome
In the graft model, the authors state that DTβ4 had antiplatelet effects and inhibited fibrinogenesis.
In plain wordsIn this graft model, the authors report that a dimeric form of thymosin β4 reduced platelet activity and fibrin formation.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePlatelet activity and fibrinogenesis
Study
rabbitn: not reported in source
carotid artery graft
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · conjugated to implanted vascular graftAs given in this study (rabbit).
Source sentences
Summary
Furthermore, highly porous structures enabled 3D patterning of conjugated heparin-binding peptide, dimeric thymosin β4 (DTβ4), which played key roles in antiplatelets, fibrinogenesis inhibition, and recruiting circulating progenitor cells, thereafter contributed to high patency rate, and unprecedent…
1 context sentence(design, population, supporting numbers)
Summary · context
We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate.
Report a problemFND-3585752603
04AnimalAnimal study (in vivo)Mechanism
In the graft model, the authors state that DTβ4 recruited circulating progenitor cells.
In plain wordsIn this graft model, the authors report that a dimeric form of thymosin β4 attracted circulating progenitor cells.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseRecruitment of circulating progenitor cells
Study
rabbitn: not reported in source
carotid artery graft
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · conjugated to implanted vascular graftAs given in this study (rabbit).
Source sentences
Summary
Furthermore, highly porous structures enabled 3D patterning of conjugated heparin-binding peptide, dimeric thymosin β4 (DTβ4), which played key roles in antiplatelets, fibrinogenesis inhibition, and recruiting circulating progenitor cells, thereafter contributed to high patency rate, and unprecedent…
1 context sentence(design, population, supporting numbers)
Summary · context
We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate.
Report a problemFND-3585752604
05AnimalAnimal study (in vivo)Mechanism
In the DTβ4 graft model, single-cell RNA sequencing and cell tracing identified myeloid-derived CD93+/CD34+ progenitor cells as the main contributor to endothelium regeneration.
In plain wordsIn rabbits with these grafts, a subset of progenitor cells was identified as the main source of the new vessel lining.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableCell source of endothelium regeneration
Study
rabbitn: not reported in source
carotid artery graft
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated · conjugated to implanted vascular graftAs given in this study (rabbit).
Source sentences
Summary
Through single-cell RNA sequencing analysis and cell tracing studies, a subset of endothelial progenitor cells, myeloid-derived CD93⁺/CD34⁺ cells, was identified as the main contributor to final endothelium regeneration.
1 context sentence(design, population, supporting numbers)
Summary · context
We fabricated 3D PGS-PCL vascular grafts, which presented tunable polymer components, porosity, mechanical strength, and degrading rate.
Report a problemFND-3585752605

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

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