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Study · Animal study (in vivo) · mouse · 2022

6 results

Humanin derivative, HNG, enhances neurotransmitter release.

Ikegawa N, Kozuka A, Morita N, Murakami M, Sasakawa N, Niikura T

Biochimica et biophysica acta. General subjects16 Jul 2022Cited by 7 (Europe PMC)

PMID35843407 (opens in a new tab)DOI10.1016/j.bbagen.2022.130204 (opens in a new tab)PepBankPUB-35843407
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Mechanism

    In wild-type young mice, intraperitoneal HNG increased hippocampal acetylcholine levels.

    In plain wordsIn mice, HNG injection raised acetylcholine levels in the hippocampus.

    Peptide
    Humanin
    Outcome
    IncreaseHippocampal acetylcholine level
    Study

    mousen: not reported in source

    wild-type young mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    The hippocampal acetylcholine (ACh) levels were increased by intraperitoneal injection of HNG.
    1 context sentence
    Summary · context
    The extracellular fluid in the hippocampus of wild-type young mice was collected by microdialysis and the amounts of neurotransmitters were measured.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In wild-type young mice, HNG did not affect physical activity.

    In plain wordsIn mice, HNG did not change physical activity.

    Peptide
    Humanin
    Outcome
    No significant changePhysical activity
    Study

    mousen: not reported in source

    wild-type young mice
    Outcome group
    Exercise and physical function · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    HNG did not affect the physical activities of the mice
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In wild-type young mice, HNG modestly improved object memory.

    In plain wordsIn mice, HNG modestly improved object memory.

    Peptide
    Humanin
    Outcome
    IncreaseObject memory
    Study

    mousen: not reported in source

    wild-type young mice
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intraperitonealAs given in this study (mouse).

    Source sentences

    Summary
    but modestly improved their object memory.
  4. 04LabIn vitro (cells)Mechanism

    In rat PC12 cells, HNG enhanced acetylcholine-induced dopamine release.

    In plain wordsIn rat nerve-like cells, HNG increased dopamine release triggered by acetylcholine.

    Peptide
    Humanin
    Outcome
    IncreaseACh-induced dopamine release
    Study

    ratn: not reported in source

    PC12 cells (rat pheochromocytoma)
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In a neuronal cell model, rat pheochromocytoma PC12 cells, HNG enhanced ACh-induced dopamine release.
  5. 05LabIn vitro (cells)Mechanism

    In primary neuroendocrine cells, HNG increased acetylcholine-induced secretory events.

    In plain wordsIn cells, HNG increased the number of release events triggered by acetylcholine.

    Peptide
    Humanin
    Outcome
    IncreaseACh-induced secretory events
    Study

    n: not reported in source

    primary neuroendocrine cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG increased ACh-induced secretory events
  6. 06LabIn vitro (cells)Mechanism

    In primary neuroendocrine cells, HNG increased vesicular quantal size.

    In plain wordsIn cells, HNG increased the amount released per vesicle.

    Peptide
    Humanin
    Outcome
    IncreaseVesicular quantal size
    Study

    n: not reported in source

    primary neuroendocrine cells
    Outcome group
    Receptor activity and mechanism · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG increased ACh-induced secretory events and vesicular quantal size in primary neuroendocrine cells.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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