Skip to content

Study · Animal study (in vivo) · rat (wistar) · 2022

7 results

Kisspeptin Treatment Restores Ovarian Function in Rats with Hypothyroidism.

de Oliveira LS, da Silva TQM, Barbosa EM, Dos Anjos Cordeiro JM, Santos LC, Henriques PC, Santos BR, Gusmao DO, de Macedo IO, Szawka RE, Silva JF

Thyroid : official journal of the American Thyroid Association16 Aug 2022Cited by 13 (Europe PMC)

PMID35765915 (opens in a new tab)DOI10.1089/thy.2021.0638 (opens in a new tab)PepBankPUB-35765915
Publisher pagePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid female rats, Kp10 restored estrous cyclicality.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 restored the estrous cycle.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseEstrous cyclicality
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    The treatment with Kp10 restored estrous cyclicality, plasma LH, ovarian and uterine morphology, and Cyp11a1, 3βHsd, and 20αHsd mRNA levels in the corpora lutea.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid female rats, Kp10 restored plasma LH, which hypothyroidism had reduced.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 restored LH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePlasma LH
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    The treatment with Kp10 restored estrous cyclicality, plasma LH, ovarian and uterine morphology, and Cyp11a1, 3βHsd, and 20αHsd mRNA levels in the corpora lutea.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid female rats, Kp10 restored ovarian and uterine morphology.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 restored the structure of ovaries and uterus.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseOvarian and uterine morphology
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    The treatment with Kp10 restored estrous cyclicality, plasma LH, ovarian and uterine morphology, and Cyp11a1, 3βHsd, and 20αHsd mRNA levels in the corpora lutea.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In hypothyroid female rats, Kp10 restored Cyp11a1, 3βHsd and 20αHsd mRNA levels in the corpora lutea.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 restored gene activity of hormone-making enzymes in the ovary.

    Peptide
    Kisspeptin-10
    Outcome
    MixedLuteal steroidogenic enzyme mRNA (Cyp11a1, 3βHsd, 20αHsd)
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    The treatment with Kp10 restored estrous cyclicality, plasma LH, ovarian and uterine morphology, and Cyp11a1, 3βHsd, and 20αHsd mRNA levels in the corpora lutea.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In hypothyroid female rats, Kp10 did not alter Kiss1 or Nkb gene expression in the arcuate nucleus.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 did not change Kiss1 or Nkb gene activity in this brain area.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKiss1 and Nkb mRNA in the arcuate nucleus
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Kp10 treatment did not alter gene expression for Kiss1 or Nkb in the ARC of hypothyroid rats.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In hypothyroid female rats, Kp10 increased pituitary Lhb mRNA levels compared with the hypothyroid group.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 raised pituitary Lhb gene activity compared with untreated hypothyroid rats.

    Peptide
    Kisspeptin-10
    Outcome
    IncreasePituitary Lhb mRNA
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Kp10 increased Lhb mRNA levels and reduced Tshb in the pituitary compared with the hypothyroid group.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In hypothyroid female rats, Kp10 reduced pituitary Tshb mRNA compared with the hypothyroid group.

    In plain wordsIn female rats with an underactive thyroid, kisspeptin‑10 lowered pituitary Tshb gene activity compared with untreated hypothyroid rats.

    Peptide
    Kisspeptin-10
    Outcome
    DecreasePituitary Tshb mRNA
    Study

    rat (Wistar)n: not reported in source

    adult female rats with propylthiouracil-induced hypothyroidism
    Comparator
    Hypothyroid rats without Kp10
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated · last month of a 3-month hypothyroidism protocolAs given in this study (rat (Wistar)).

    Source sentences

    Summary
    Kp10 increased Lhb mRNA levels and reduced Tshb in the pituitary compared with the hypothyroid group.
    2 context sentences
    Summary · context
    Hypothyroidism was induced in adult female Wistar rats using 6-propyl-2-thiouracil for 3 months.
    Summary · context
    In the last month, half of the animals received Kp10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.