Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.

Smoday IM, Petrovic I, Kalogjera L, Vranes H, Zizek H, Krezic I, Gojkovic S, Skorak I, Hriberski K, Brizic I, Kubat M, Strbe S and 8 more

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Barisic I, Sola M, Lovric E, Lozic M, Boban Blagaic A, Skrtic A, Seiwerth S, Sikiric P

Biomedicines1 Jun 2022Cited by 24 (Europe PMC)

PMID35740321PMCIDPMC9220115DOI10.3390/biomedicines10061299PepBankPUB-35740321

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Summary

We revealed the therapy effect of the stable gastric pentadecapeptide BPC 157 (10 μg/kg, 10 ng/kg ig or po) with specific activation of the collateral rescuing pathways, the azygos vein, on bile duct ligation in particular, and acute pancreatitis as local disturbances (i.e., improved gross and microscopy presentation, decreased amylase level). Additionally, we revealed the therapy's effect on the acute pancreatitis as vascular failure and multiorgan failure, both peripherally and centrally following "occlusion-like" syndrome, major intoxication (alcohol, lithium), maintained severe intra-abdominal hypertension, and myocardial infarction, or occlusion syndrome, and major vessel occlusion. The application-sacrifice periods were ligation times of 0-30 min, 0-5 h, 0-24 h (cured periods, early regimen) and 4.30 h-5 h, 5 h-24 h (cured periods, delayed regimen). Otherwise, bile duct-ligated rats commonly presented intracranial (superior sagittal sinus), portal and caval hypertension and aortal hypotension, gross brain swelling, hemorrhage and lesions, heart dysfunction, lung lesions, liver and kidney failure, gastrointestinal lesions, and severe arterial and venous thrombosis, peripherally and centrally. Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage). These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats. To summarize, while the innate vicious cycle may be peripheral (bile duct ligation), or central (rapidly developed brain disturbances), or peripheral and central, BPC 157 resolved acute pancreatitis and its adjacent syndrome.

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with bile duct ligation and acute pancreatitis, BPC‑157 therapy improved gross and microscopy presentation.
In plain wordsIn rats with acute pancreatitis, BPC‑157 improved how the pancreas looked to the eye and under the microscope.
Peptide
BPC-157
Outcome
IncreaseGross and microscopic presentation of the pancreas
Study
ratn: not reported in source
Bile duct ligation and acute pancreatitis
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 μg/kg and 10 ng/kg · intragastric or oralAs given in this study (rat).
Source sentences
Summary
improved gross and microscopy presentation, decreased amylase level)
2 context sentences(design, population, supporting numbers)
Title · context
Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.
Summary · context
The application-sacrifice periods were ligation times of 0-30 min, 0-5 h, 0-24 h (cured periods, early regimen) and 4.30 h-5 h, 5 h-24 h (cured periods, delayed regimen).
Show in the study text Report a problemFND-3574032101
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with bile duct ligation and acute pancreatitis, BPC‑157 therapy decreased the amylase level.
In plain wordsIn rats with acute pancreatitis, BPC‑157 lowered the level of the enzyme amylase.
Peptide
BPC-157
Outcome
DecreaseAmylase level
Study
ratn: not reported in source
Bile duct ligation and acute pancreatitis
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
10 μg/kg and 10 ng/kg · intragastric or oralAs given in this study (rat).
Source sentences
Summary
improved gross and microscopy presentation, decreased amylase level)
2 context sentences(design, population, supporting numbers)
Title · context
Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.
Summary · context
The application-sacrifice periods were ligation times of 0-30 min, 0-5 h, 0-24 h (cured periods, early regimen) and 4.30 h-5 h, 5 h-24 h (cured periods, delayed regimen).
Show in the study text Report a problemFND-3574032102
03AnimalAnimal study (in vivo)Mechanism
In rats with bile duct ligation, BPC‑157 regimens reversed inferior caval and superior mesenteric vein congestion and reversed the failed azygos vein, activating direct delivery to rescue the caval vein pathway.
In plain wordsIn rats with a blocked bile duct, BPC‑157 reversed vein congestion and opened a rescue blood route.
Peptide
BPC-157
Outcome
DecreaseReversal of caval and mesenteric vein congestion and azygos vein failure
Study
ratn: not reported in source
Bile duct ligation and acute pancreatitis
Outcome group
Cardiovascular events · Cardiovascular
Studied dose
10 μg/kg and 10 ng/kg · intragastric or oralAs given in this study (rat).
Source sentences
Summary
Unless antagonized with the key effect of BPC 157 regimens, reversal of the inferior caval and superior mesenteric vein congestion and reversal of the failed azygos vein activated azygos vein-recruited direct delivery to rescue the inferior-superior caval vein pathway; these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage).
2 context sentences(design, population, supporting numbers)
Title · context
Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.
Summary · context
The application-sacrifice periods were ligation times of 0-30 min, 0-5 h, 0-24 h (cured periods, early regimen) and 4.30 h-5 h, 5 h-24 h (cured periods, delayed regimen).
Show in the study text Report a problemFND-3574032103
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with bile duct ligation, the late-appearing major lesions of acute pancreatitis, such as hemorrhage, were markedly attenuated or eliminated in BPC‑157-treated rats.
In plain wordsIn rats with acute pancreatitis, BPC‑157 greatly reduced or removed the main pancreas damage, such as bleeding.
Peptide
BPC-157
Outcome
DecreaseAcute pancreatitis major lesions (acinar and fat necrosis, hemorrhage)
Study
ratn: not reported in source
Bile duct ligation and acute pancreatitis
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
10 μg/kg and 10 ng/kg · intragastric or oralAs given in this study (rat).
Source sentences
Summary
These lesions appeared in the later period, but were markedly attenuated/eliminated (i.e., hemorrhage) in BPC 157-treated rats.
3 context sentences(design, population, supporting numbers)
Summary · context
these were all antecedent to acute pancreatitis major lesions (i.e., acinar, fat necrosis, hemorrhage)
Title · context
Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.
Summary · context
The application-sacrifice periods were ligation times of 0-30 min, 0-5 h, 0-24 h (cured periods, early regimen) and 4.30 h-5 h, 5 h-24 h (cured periods, delayed regimen).
Show in the study text Report a problemFND-3574032104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Therapy Effect of the Stable Gastric Pentadecapeptide BPC 157 on Acute Pancreatitis as Vascular Failure-Induced Severe Peripheral and Central Syndrome in Rats.

Summary

Results from this study4

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