Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and D-galactose induced senescent cells.

Ru M, Wang W, Zhai Z, Wang R, Li Y, Liang J, Kothari D, Niu K, Wu X

Food & function18 Jul 2022Cited by 51 (Europe PMC)

PMID35678708DOI10.1039/d2fo00525ePepBankPUB-35678708

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study23

23 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN had little impact on colonic microbiota.
In plain wordsIn aging mice, NMN had little effect on colonic microbiota.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
No significant changeColonic microbiota
Study
mousen: not reported in source
Aging mice
Outcome group
Gut microbiota · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
The results showed that 4 months of NMN administration had little impact on the colonic microbiota and NAD⁺ content in aging mice, while it significantly increased the jejunal NAD⁺ content and improved the jejunal structure including increasing the villus length and shortening the crypt.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870801
02AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN had little impact on colonic NAD+ content.
In plain wordsIn aging mice, NMN had little effect on colonic NAD+ content.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
No significant changeColonic NAD+ content
Study
mousen: not reported in source
Aging mice
Outcome group
Metabolic pathways and metabolomics · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
The results showed that 4 months of NMN administration had little impact on the colonic microbiota and NAD⁺ content in aging mice, while it significantly increased the jejunal NAD⁺ content and improved the jejunal structure including increasing the villus length and shortening the crypt.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870802
03AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN significantly increased jejunal NAD+ content.
In plain wordsIn aging mice, NMN increased NAD+ content in the jejunum.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseJejunal NAD+ content
Study
mousen: not reported in source
Aging mice
Outcome group
Metabolic pathways and metabolomics · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
The results showed that 4 months of NMN administration had little impact on the colonic microbiota and NAD⁺ content in aging mice, while it significantly increased the jejunal NAD⁺ content and improved the jejunal structure including increasing the villus length and shortening the crypt.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870803
04AnimalAnimal study (in vivo)Efficacy outcome
In aging mice, NMN increased jejunal villus length.
In plain wordsIn aging mice, NMN increased intestinal villus length.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseJejunal villus length
Study
mousen: not reported in source
Aging mice
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
The results showed that 4 months of NMN administration had little impact on the colonic microbiota and NAD⁺ content in aging mice, while it significantly increased the jejunal NAD⁺ content and improved the jejunal structure including increasing the villus length and shortening the crypt.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870804
05AnimalAnimal study (in vivo)Efficacy outcome
In aging mice, NMN shortened jejunal crypts.
In plain wordsIn aging mice, NMN shortened intestinal crypts.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseJejunal crypt length
Study
mousen: not reported in source
Aging mice
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
The results showed that 4 months of NMN administration had little impact on the colonic microbiota and NAD⁺ content in aging mice, while it significantly increased the jejunal NAD⁺ content and improved the jejunal structure including increasing the villus length and shortening the crypt.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870805
06AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased SIRT3 mRNA expression.
In plain wordsIn aging mice, NMN increased SIRT3 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT3 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Aging markers · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870806
07AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased SIRT6 mRNA expression.
In plain wordsIn aging mice, NMN increased SIRT6 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSIRT6 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Aging markers · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870807
08AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased Nrf2 mRNA expression.
In plain wordsIn aging mice, NMN increased Nrf2 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNrf2 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870808
09AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased HO-1 mRNA expression.
In plain wordsIn aging mice, NMN increased HO-1 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseHO-1 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870809
10AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased GCLC mRNA expression.
In plain wordsIn aging mice, NMN increased GCLC gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseGCLC mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870810
11AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased SOD2 mRNA expression.
In plain wordsIn aging mice, NMN increased SOD2 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseSOD2 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870811
12AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased occludin mRNA expression.
In plain wordsIn aging mice, NMN increased occludin gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOccludin mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870812
13AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN increased claudin-1 mRNA expression.
In plain wordsIn aging mice, NMN increased claudin-1 gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseClaudin-1 mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870813
14AnimalAnimal study (in vivo)Mechanism
In aging mice, NMN reduced TNF-α mRNA expression.
In plain wordsIn aging mice, NMN reduced TNF-α gene expression.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseTNF-α mRNA
Study
mousen: not reported in source
Aging mice
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
Dose not stated · 4 monthsAs given in this study (mouse).
Source sentences
Summary
Moreover, NMN supplementation significantly up-regulated the mRNA expression of SIRT3, SIRT6, nuclear factor E2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), the catalytic subunit of glutamate-cysteine ligase (GCLC), superoxide dismutase 2 (SOD2), occludin, and claudin-1, but down-regulated the…
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870814
15LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN partly restored elevated IL6ST mRNA toward normal levels.
In plain wordsIn cells, NMN partly reduced elevated IL6ST gene expression toward normal levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL6ST mRNA
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
500 μMAs given in this study.
Source sentences
Summary
Specifically, in the D-gal induced senescent IPEC-J2 cells, 500 μM NMN restored the increased mRNA expression of interleukin 6 (IL6ST), IL-1A, nuclear factor (NF-κB1), and claudin-1 to normal levels to some extent.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870815
16LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN partly restored elevated IL-1A mRNA toward normal levels.
In plain wordsIn cells, NMN partly reduced elevated IL-1A gene expression toward normal levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseIL-1A mRNA
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
500 μMAs given in this study.
Source sentences
Summary
Specifically, in the D-gal induced senescent IPEC-J2 cells, 500 μM NMN restored the increased mRNA expression of interleukin 6 (IL6ST), IL-1A, nuclear factor (NF-κB1), and claudin-1 to normal levels to some extent.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870816
17LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN partly restored elevated NF-κB1 mRNA toward normal levels.
In plain wordsIn cells, NMN partly reduced elevated NF-κB1 gene expression toward normal levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseNF-κB1 mRNA
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
500 μMAs given in this study.
Source sentences
Summary
Specifically, in the D-gal induced senescent IPEC-J2 cells, 500 μM NMN restored the increased mRNA expression of interleukin 6 (IL6ST), IL-1A, nuclear factor (NF-κB1), and claudin-1 to normal levels to some extent.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870817
18LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN partly restored elevated claudin-1 mRNA toward normal levels.
In plain wordsIn cells, NMN partly reduced elevated claudin-1 gene expression toward normal levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseClaudin-1 mRNA
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
500 μMAs given in this study.
Source sentences
Summary
Specifically, in the D-gal induced senescent IPEC-J2 cells, 500 μM NMN restored the increased mRNA expression of interleukin 6 (IL6ST), IL-1A, nuclear factor (NF-κB1), and claudin-1 to normal levels to some extent.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870818
19LabIn vitro (cells)Efficacy outcome
In senescent IPEC-J2 cells, NMN enhanced cell viability.
In plain wordsIn cells, NMN increased viability during induced senescence.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseCell viability
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Cell viability and death · Gastrointestinal
Studied dose
200 μMAs given in this study.
Source sentences
Summary
In addition, 200 μM NMN enhanced the cell viability and total antioxidant capacity and lowered the reactive oxygen species level of senescent IPEC-J2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870819
20LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN enhanced total antioxidant capacity.
In plain wordsIn cells, NMN increased total antioxidant capacity during induced senescence.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseTotal antioxidant capacity
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
200 μMAs given in this study.
Source sentences
Summary
In addition, 200 μM NMN enhanced the cell viability and total antioxidant capacity and lowered the reactive oxygen species level of senescent IPEC-J2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870820
21LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN lowered ROS levels.
In plain wordsIn cells, NMN reduced ROS levels during induced senescence.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
DecreaseROS levels
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Oxidative stress · Gastrointestinal
Studied dose
200 μMAs given in this study.
Source sentences
Summary
In addition, 200 μM NMN enhanced the cell viability and total antioxidant capacity and lowered the reactive oxygen species level of senescent IPEC-J2 cells.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870821
22LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN restored occludin protein expression reduced by D-galactose.
In plain wordsIn cells, NMN restored occludin protein expression after D-galactose reduced it.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseOccludin protein expression
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Notably, NMN restored the down-regulated protein expression of occludin and claudin-1 induced by D-gal.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870822
23LabIn vitro (cells)Mechanism
In senescent IPEC-J2 cells, NMN restored claudin-1 protein expression reduced by D-galactose.
In plain wordsIn cells, NMN restored claudin-1 protein expression after D-galactose reduced it.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseClaudin-1 protein expression
Study
n: not reported in source
D-galactose-induced senescent IPEC-J2 cells
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
Dose not stated
Source sentences
Summary
Notably, NMN restored the down-regulated protein expression of occludin and claudin-1 induced by D-gal.
1 context sentence(design, population, supporting numbers)
Summary · context
In the current study, to explore whether NMN has an impact on the intestine during the aging process, the effects of NMN supplementation on the intestinal morphology, microbiota, and NAD⁺ content, as well as its anti-inflammatory, anti-oxidative and barrier functions were investigated in…
Report a problemFND-3567870823

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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