Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy.

Perovic D, Milavic M, Dokuzovic S, Krezic I, Gojkovic S, Vranes H, Bebek I, Bilic V, Somun N, Brizic I, Skorak I, Hriberski K and 8 more

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Sikiric S, Lovric E, Strbe S, Kubat M, Boban Blagaic A, Skrtic A, Seiwerth S, Sikiric P

Current issues in molecular biology27 Apr 2022Cited by 17 (Europe PMC)

PMID35678659PMCIDPMC9164058DOI10.3390/cimb44050130PepBankPUB-35678659

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Summary

Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury. Besides the demonstrated rapid and sustained recovery (1 year), we showed the particular points of the immediate effect of the BPC 157 therapy that began rapidly after its administration, (i) soon after injury (10 min), or (ii) later (4 days), in the rats with a definitive spinal cord injury. Specifically, in counteracting spinal cord hematoma and swelling, (i) in rats that had undergone acute spinal cord injury, followed by intraperitoneal BPC 157 application at 10 min, we focused on the first 10-30 min post-injury period (assessment of gross, microscopic, and gene expression changes). Taking day 4 post-injury as the definitive injury, (ii) we focused on the immediate effects after the BPC 157 intragastric application over 20 min of the post-therapy period. Comparable long-time recovery was noted in treated rats which had definitive tail paralysis: (iii) the therapy was continuously given per orally in drinking water, beginning at day 4 after injury and lasting one month after injury. BPC 157 rats presented only discrete edema and minimal hemorrhage and increased Nos1, Nos2, and Nos3 values (30 min post-injury, (i)) or only mild hemorrhage, and only discrete vacuolation of tissue (day 4, (ii)). In the day 4-30 post-injury study (iii), BPC 157 rats rapidly presented tail function recovery, and no demyelination process (Luxol fast blue staining).

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with acute spinal cord compression injury, BPC‑157 given intraperitoneally at 10 min left only discrete edema and minimal hemorrhage at 30 min post-injury.
In plain wordsIn rats with spinal cord injury, BPC‑157 treatment was followed by only slight swelling and bleeding in the cord.
Peptide
BPC-157
Outcome
DecreaseSpinal cord edema and hemorrhage at 30 min post-injury
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
BPC 157 rats presented only discrete edema and minimal hemorrhage
1 context sentence(design, population, supporting numbers)
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865901
02AnimalAnimal study (in vivo)Mechanism
In rats with acute spinal cord injury, BPC‑157 treatment was followed by increased Nos1, Nos2 and Nos3 values at 30 min post-injury.
In plain wordsIn rats with spinal cord injury, BPC‑157 treatment was followed by higher activity of three nitric oxide synthase genes.
Peptide
BPC-157
Outcome
IncreaseNos1, Nos2 and Nos3 expression at 30 min post-injury
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intraperitonealAs given in this study (rat).
Source sentences
Summary
increased Nos1, Nos2, and Nos3 values
1 context sentence(design, population, supporting numbers)
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with definitive spinal cord injury at day 4, intragastric BPC‑157 was followed by only mild hemorrhage.
In plain wordsIn rats with an older spinal cord injury, BPC‑157 given into the stomach was followed by only mild bleeding in the cord.
Peptide
BPC-157
Outcome
DecreaseHemorrhage at day 4 after injury, immediate effect of intragastric BPC 157
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intragastricAs given in this study (rat).
Source sentences
Summary
or only mild hemorrhage
2 context sentences(design, population, supporting numbers)
Summary · context
Taking day 4 post-injury as the definitive injury, (ii) we focused on the immediate effects after the BPC 157 intragastric application over 20 min of the post-therapy period.
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with definitive spinal cord injury at day 4, intragastric BPC‑157 was followed by only discrete vacuolation of tissue.
In plain wordsIn rats with an older spinal cord injury, BPC‑157 given into the stomach was followed by only slight tissue vacuolation.
Peptide
BPC-157
Outcome
DecreaseTissue vacuolation at day 4 after injury
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · intragastricAs given in this study (rat).
Source sentences
Summary
and only discrete vacuolation of tissue (day 4, (ii)).
2 context sentences(design, population, supporting numbers)
Summary · context
Taking day 4 post-injury as the definitive injury, (ii) we focused on the immediate effects after the BPC 157 intragastric application over 20 min of the post-therapy period.
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with definitive tail paralysis, BPC‑157 in drinking water from day 4 was followed by rapid recovery of tail function.
In plain wordsIn rats with tail paralysis from spinal cord injury, BPC‑157 in drinking water was followed by quick recovery of tail function.
Peptide
BPC-157
Outcome
IncreaseTail function recovery, day 4 to day 30 post-injury
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral, in drinking water · from day 4 to one month after injuryAs given in this study (rat).
Source sentences
Summary
BPC 157 rats rapidly presented tail function recovery
2 context sentences(design, population, supporting numbers)
Summary · context
Comparable long-time recovery was noted in treated rats which had definitive tail paralysis: (iii) the therapy was continuously given per orally in drinking water, beginning at day 4 after injury and lasting one month after injury.
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with definitive tail paralysis, BPC‑157 in drinking water from day 4 was followed by no demyelination process on Luxol fast blue staining.
In plain wordsIn rats with tail paralysis from spinal cord injury, treated with BPC‑157 in drinking water, no loss of nerve insulation (myelin) was seen.
Peptide
BPC-157
Outcome
No significant changeDemyelination (Luxol fast blue staining), day 4 to day 30
Study
ratn: not reported in source
Sacrocaudal spinal cord compression injury (S2-Co1, 1 min)
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · oral, in drinking water · from day 4 to one month after injuryAs given in this study (rat).
Source sentences
Summary
and no demyelination process (Luxol fast blue staining).
2 context sentences(design, population, supporting numbers)
Summary · context
Comparable long-time recovery was noted in treated rats which had definitive tail paralysis: (iii) the therapy was continuously given per orally in drinking water, beginning at day 4 after injury and lasting one month after injury.
Summary · context
Recently, marked therapeutic effects pertaining to the recovery of injured rat spinal cords (1 min compression injury of the sacrocaudal spinal cord (S2-Co1) resulting in tail paralysis) appeared after a single intraperitoneal administration of the stable gastric pentadecapeptide BPC 157 at 10 min post-injury.
Show in the study text Report a problemFND-3567865906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Novel Therapeutic Effects in Rat Spinal Cord Injuries: Recovery of the Definitive and Early Spinal Cord Injury by the Administration of Pentadecapeptide BPC 157 Therapy.

Summary

Results from this study6

Version history

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