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Study · PubMed tag: none · 2022

Retracted

GLP-1 Analog Alleviated Cognitive Dysfunction in Aged Rats Anaesthetized with Sevoflurane.

Zhang Q, Jiang Y, Zhang Y, Zhang J, Hu Y

BioMed research international16 May 2022Cited by 4 (Europe PMC)

PMID35615010 (opens in a new tab)PMCIDPMC9126689 (opens in a new tab)DOI10.1155/2022/9339824 (opens in a new tab)PepBankPUB-35615010
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Summary

Postoperative cognitive dysfunction (POCD) in elderly patients undergoing general anesthesia is a major problem in the aging society. Sevoflurane is the most widely applied anesthetic in clinical practice. In this study, we investigated the effects of the GLP-1 analogue liraglutide on cognitive function in aged rats anesthetized by sevoflurane. Specifically, 48 Sprague-Dawley rats were divided into the control (C) group, the liraglutide (L) group, the sevoflurane (S) group, and the sevoflurane+liraglutide (SL) group, each group with 12 rats. In the S group and the SL group, the rats were injected subcutaneously with normal saline and liraglutide after inhalation of a mixture of 3% sevoflurane and pure oxygen. In the C group and the L group, normal saline and liraglutide were injected subcutaneously into the rats after inhalation of pure oxygen. Morris Water Maze Task was applied for the detection of spatial learning and memory in rats; HE and TUNEL for staining; and western blot for quantifying Bax, Bcl-2 expression, and examining caspase-3 activity in hippocampal tissues as well as for revealing the antiapoptotic mechanism. Besides, the accumulation of inflammatory factors NF-κB and IL-1β in the hippocampal tissue was quantitatively studied to reveal the anti-inflammatory mechanism. The protective effect of liraglutide on sevoflurane toxicity was the first to be confirmed in this study. Additionally, this study elucidated the mechanism of the above effect. The results of this study might be helpful to find an effective medical solution for the treatment of POCD caused by sevoflurane anesthesia.
CC BYText from Europe PMC. No result points at this text yet.

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Versions 2 to 10Current

    27 Oct 2026, 16:37 UTC

    The same notice was added 9 times, first on 9 Oct 2026, 03:15 UTC. The status did not change between them.

    Status changed: status, notices · status retracted · status notice from Retraction Watch (Crossref)

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · status retracted · source update from Europe PMC

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