Novel insight into Robert's cytoprotection: complex therapeutic effect of cytoprotective pentadecapeptide pentadecapeptide BPC 157 in rats with perforated stomach throughout modulation of nitric oxide-system. Comparison with L-arginine, ranitidine and pantoprazole therapy and L-N^G-nitro-L-arginine methyl ester worsening.

Bilic Z, Gojkovic S, Kalogjera L, Krezic I, Malekinusic D, Knezevic M, Sever M, Lojo N, Kokot A, Kasnik K, Kralj T, Vukojevic J and 15 more

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Siroglavic M, Peklic M, Drmic D, Milavic M, Sikiric S, Skorak I, Brizic I, Hriberski K, Kubat M, Vladic J, Boban Blagaic A, Tvrdeic A, Skrtic A, Seiwerth S, Sikiric P

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society1 Dec 2021Cited by 8 (Europe PMC)

PMID35485358DOI10.26402/jpp.2021.6.11PepBankPUB-35485358

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with perforated stomach, BPC‑157 rapidly restored vessels toward the perforated defect within 1-15 min.
In plain wordsIn rats with a hole in the stomach, BPC‑157 quickly brought blood vessels back toward the damaged area.
Peptide
BPC-157
Outcome
IncreaseVessel filling toward the perforated defect (1-15 min)
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
with cytoprotective BPC 157 (0.01 μg), the rapidly restored vessels 'run' (vessels filled/reappeared) toward the perforated defect
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535801
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with perforated stomach, BPC‑157 was followed by less bleeding within 1-15 min.
In plain wordsIn rats with a hole in the stomach, BPC‑157 led to less bleeding than saline in the first minutes.
Peptide
BPC-157
Outcome
DecreaseBleeding within 1-15 min
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
with cytoprotective BPC 157 (0.01 μg), the rapidly restored vessels 'run' (vessels filled/reappeared) toward the perforated defect, and there is less bleeding
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535802
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with perforated stomach, BPC‑157 was followed by contraction of the perforated defect.
In plain wordsIn rats with a hole in the stomach, BPC‑157 was followed by the hole becoming smaller.
Peptide
BPC-157
Outcome
DecreaseDefect contraction
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
with cytoprotective BPC 157 (0.01 μg), the rapidly restored vessels 'run' (vessels filled/reappeared) toward the perforated defect, and there is less bleeding, and defect contraction
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535803
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with perforated stomach, BPC‑157 was followed by advanced lesion healing at day 1 and complete healing at day 7.
In plain wordsIn rats with a hole in the stomach, BPC‑157 was followed by faster healing, complete by day 7.
Peptide
BPC-157
Outcome
IncreasePerforated lesion healing (day 1 and day 7)
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Wound healing · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
advanced perforated lesion healing (day 1) to complete healing (day 7)
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535804
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with perforated stomach, BPC‑157 was followed by fewer adhesions.
In plain wordsIn rats with a hole in the stomach, BPC‑157 led to fewer scar-like attachments between tissues.
Peptide
BPC-157
Outcome
DecreaseAdhesions
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Gastrointestinal protection · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
and less adhesions.
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535805
06AnimalAnimal study (in vivo)Efficacy outcome
In stomach tissue around the defect, BPC‑157 reversed increased malondialdehyde values to normal.
In plain wordsIn rats with a hole in the stomach, BPC‑157 brought a raised tissue stress marker back to normal values.
Peptide
BPC-157
Outcome
DecreaseTissue malondialdehyde (MDA) around the defect
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Inflammation markers · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
increased malondialdehyde (MDA)- and decreased NO-values, BPC 157 reversed to the normal healthy values
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535806
07AnimalAnimal study (in vivo)Efficacy outcome
In stomach tissue around the defect, BPC‑157 reversed decreased NO values to normal.
In plain wordsIn rats with a hole in the stomach, BPC‑157 brought a lowered tissue nitric oxide level back to normal.
Peptide
BPC-157
Outcome
IncreaseTissue nitric oxide (NO) around the defect
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
increased malondialdehyde (MDA)- and decreased NO-values, BPC 157 reversed to the normal healthy values
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535807
08AnimalAnimal study (in vivo)Mechanism
In rats with perforated stomach, mRNA expression studies of Cox2, VEGFa, Nos1-3 and Nkap indicated that BPC‑157 may act via the NO- and prostaglandin systems.
In plain wordsIn rats with a hole in the stomach, gene tests suggest BPC‑157 may act through nitric oxide and prostaglandin pathways.
Peptide
BPC-157
Outcome
Direction not reportedGene expression (Cox2, VEGFa, Nos1, Nos2, Nos3, Nkap) early after perforation
Study
ratn: not reported in source
Surgically perforated stomach
Comparator
Saline control
Outcome group
Receptor activity and mechanism · Gastrointestinal
Studied dose
0.01 µg · abdominal bath (10 ml/rat for 2 min)As given in this study (rat).
Source sentences
Summary
mRNA expression studies (Cox2, VEGFa, Nos1, Nos 2, Nos3, Nkap (NF-kappa-B-activating protein gene)), done at that very early post-perforation-time, indicate a way how BPC 157 may act beneficially in the perforated stomach lesion throughout NO- and prostaglandinds-system
2 context sentences(design, population, supporting numbers)
Summary · context
Surgically perforated stomach (since direct injury in rats until persisting defect and huge adhesions (day 1, day 7)) fairly represent an unresolved cytoprotection issue, and thereby, we focused resolving of the immediate triad, particular vascular failure (vessels 'disappear'/empty), prolonged blee…
Summary · context
Agents (mg/kg) or saline (controls) were given at 1 min post-injury as an abdominal bath (10 ml/rat throughout 2 min).
Report a problemFND-3548535808

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
10 Oct 2026, 08:19 UTC
Study results updated
Version 2
9 Oct 2026, 03:03 UTC
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 02:56 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

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