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Study · Randomized controlled trial · n = 160 · 2022

4 results

The Effect of Intranasal Oxytocin on the Association Between Couple Interaction and Sleep: A Placebo-Controlled Study.

Doerr JM, Klaus K, Troxel W, Nater UM, Bodenmann G, Heinrichs M, Ehlert U, Ditzen B

Psychosomatic medicine27 Apr 2022Cited by 5 (Europe PMC)

PMID35472193 (opens in a new tab)DOI10.1097/psy.0000000000001091 (opens in a new tab)PepBankPUB-35472193
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In heterosexual couples, people given intranasal oxytocin reported higher sleep quality than people given placebo.

    In plain wordsIn couples, people given oxytocin spray reported better sleep quality than people given placebo spray.

    Peptide
    Oxytocin
    Outcome
    IncreaseSelf-reported sleep quality
    Study

    n = 160

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    32 international units · intranasal · 5 consecutive daysAs given in this study (human).

    Source sentences

    Summary
    Persons with OT reported higher levels of sleep quality than those without ( B = 0.47, t (74) = 2.32, p = .023).
    1 context sentence
    Summary · context
    Eighty heterosexual couples ( N = 160 individuals, mean [standard deviation] age = 28 [5] years) were randomized to self-administer a) 32 international units of intranasal OT or b) placebo during 5 consecutive days.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In heterosexual couples, the association between closeness and sleep quality was stronger with oxytocin than with placebo.

    In plain wordsIn couples, the link between feeling close and sleeping well was stronger with oxytocin than with placebo.

    Peptide
    Oxytocin
    Outcome
    IncreaseAssociation of closeness with sleep quality (OT by closeness)
    Study

    n = 160

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    32 international units · intranasal · 5 consecutive daysAs given in this study (human).

    Source sentences

    Summary
    The association between closeness and sleep quality was stronger with OT than without (OT by closeness: B = 0.31, t (72) = 2.29, p = .025; OT by valence of interaction: B = 0.27, t (72) = 1.77, p = .081).
    1 context sentence
    Summary · context
    Eighty heterosexual couples ( N = 160 individuals, mean [standard deviation] age = 28 [5] years) were randomized to self-administer a) 32 international units of intranasal OT or b) placebo during 5 consecutive days.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In heterosexual couples, oxytocin did not significantly change the association between valence of couple interaction and sleep quality.

    In plain wordsIn couples, oxytocin did not clearly change the link between positive couple interaction and sleep quality.

    Peptide
    Oxytocin
    Outcome
    No significant changeAssociation of valence of couple interaction with sleep quality (OT by valence)
    Study

    n = 160

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    32 international units · intranasal · 5 consecutive daysAs given in this study (human).

    Source sentences

    Summary
    The association between closeness and sleep quality was stronger with OT than without (OT by closeness: B = 0.31, t (72) = 2.29, p = .025; OT by valence of interaction: B = 0.27, t (72) = 1.77, p = .081).
    1 context sentence
    Summary · context
    Eighty heterosexual couples ( N = 160 individuals, mean [standard deviation] age = 28 [5] years) were randomized to self-administer a) 32 international units of intranasal OT or b) placebo during 5 consecutive days.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In heterosexual couples, the oxytocin effects on sleep quality were especially pronounced in women.

    In plain wordsIn couples, the effects of oxytocin on sleep quality were especially strong in women.

    Peptide
    Oxytocin
    Outcome
    IncreaseSex difference in the oxytocin effect on sleep quality
    Study

    n: not reported in source

    Comparator
    Placebo
    Outcome group
    Sleep · Sleep
    Studied dose
    32 international units · intranasal · 5 consecutive daysAs given in this study (human).

    Source sentences

    Summary
    the OT effects were especially pronounced in women.
    1 context sentence
    Summary · context
    Eighty heterosexual couples ( N = 160 individuals, mean [standard deviation] age = 28 [5] years) were randomized to self-administer a) 32 international units of intranasal OT or b) placebo during 5 consecutive days.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 1NCT01594775

Oxytocin, Couple Interaction and Wound Healing

University of Zurichn = 160Oct 2011 to Oct 2013

Healthy Volunteers

Trial pageClinicalTrials.govUpdated 25 Feb 2014

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    11 Oct 2026, 00:50 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:48 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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