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Study · Animal study (in vivo) · rat · 2022

6 results

The anti-nociceptive effect of BPC-157 on the incisional pain model in rats.

Jung YH, Kim H, Kim H, Kim E, Baik J, Kang H

Journal of dental anesthesia and pain medicine25 Mar 2022Cited by 15 (Europe PMC)

PMID35449779 (opens in a new tab)PMCIDPMC8995671 (opens in a new tab)DOI10.17245/jdapm.2022.22.2.97 (opens in a new tab)PepBankPUB-35449779
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with plantar incision, BPC‑157 at 10, 20 and 40 µg/kg raised the mechanical allodynia threshold versus control at 2 h.

    In plain wordsIn rats with an incision on the paw, BPC‑157 made the paws less sensitive to touch than saline at 2 hours.

    Peptide
    BPC-157
    Outcome
    IncreaseMechanical allodynia threshold at 2 h after incision
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The threshold of mechanical allodynia was significantly increased in the BPC10, BPC20, BPC40 and morphine groups compared with that in the control group at 2 h.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with plantar incision, the raised mechanical thresholds then returned to the level of the control group.

    In plain wordsIn rats with an incision on the paw, the lower touch sensitivity after BPC‑157 went back to the level of the saline group.

    Peptide
    BPC-157
    Outcome
    No significant changeMechanical allodynia threshold after 2 h (return to control level)
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    These increasing thresholds then returned to the levels of the control group.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with plantar incision, the BPC‑157 group had a much higher mechanical threshold than control at 4 days.

    In plain wordsIn rats with an incision on the paw, BPC‑157 rats were much less sensitive to touch than saline rats at 4 days.

    Peptide
    BPC-157
    Outcome
    IncreaseMechanical allodynia threshold at 4 days after incision
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The BPC-157 group showed a much higher threshold at 4 days after incision than the control group.
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with plantar incision, the thresholds of the BPC‑157 groups were normalized at 7 days after incision.

    In plain wordsIn rats with an incision on the paw, touch sensitivity of the BPC‑157 groups was back to normal at 7 days.

    Peptide
    BPC-157
    Outcome
    No significant changeMechanical allodynia threshold at 7 days after incision
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The thresholds of the BPC groups, except the morphine group, were normalized 7 days after incision
    2 context sentences
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the formalin test, flinching numbers were significantly decreased in phase 1 in the BPC10, BPC20 and BPC40 groups.

    In plain wordsIn rats in the formalin test, BPC‑157 reduced paw flinching in the first phase of the test.

    Peptide
    BPC-157
    Outcome
    DecreaseFormalin test flinching number, phase 1
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    The flinching numbers of the BPC10, BPC20, BPC40 and morphine groups were significantly decreased in phase 1
    3 context sentences
    Summary · context
    The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization.
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats in the formalin test, there was no decrease in flinching in the BPC‑157 groups in phase 2.

    In plain wordsIn rats in the formalin test, BPC‑157 did not reduce paw flinching in the second phase of the test.

    Peptide
    BPC-157
    Outcome
    No significant changeFormalin test flinching number, phase 2
    Study

    ratn: not reported in source

    Plantar incisional pain model (Sprague-Dawley)
    Comparator
    Saline control
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    10, 20 or 40 µg/kgAs given in this study (rat).

    Source sentences

    Summary
    but there was no decrease in the BPC-157 groups except the morphine group in phase 2.
    3 context sentences
    Summary · context
    The formalin test was also performed to differentiate its anti-nociceptive effect from an inflammatory reaction or central sensitization.
    Summary · context
    Sprague-Dawley rats were randomly divided into five groups: control (saline with the same volume), BPC10 (10 µg/kg of BPC-157), BPC20 (20 µg/kg of BPC-157), BPC40 (40 µg/kg of BPC-157), and morphine (5 mg/kg of morphine).
    Summary · context
    A 1-cm longitudinal incision was made through the skin, fascia, and muscle of the plantar aspect of the hind paw in isoflurane-anesthetised rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

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