Role of Thymosin Beta 4 in the diagnosis of Nonalcoholic Fatty Liver and its relation to Metabolic Syndrome in Egyptian patients.

Ahmed AE, Ibrahim WA, Nabil ZM, Mansour KA, Mansour AMF, ElGhandour AM

The Egyptian journal of immunology1 Apr 2022Cited by 1 (Europe PMC)

PMID35436057DOI10.55133/eji.290209PepBankPUB-35436057

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

No result from this study comes from a test of the peptide.

Natural levels measured9

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01HumanEndogenous levelObservational studyOther
In adults with NAFLD, serum Tβ4 was significantly lower than in controls.
In plain wordsAdults with fatty liver had lower levels of the body's own Tβ4 than controls.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseSerum Tβ4 in NAFLD versus controls
Study
n = 80
Comparator
Controls without NAFLD
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Serum Tβ4 was significantly lower in NAFLD patients (P < 0.001) and there was a significant positive correlation between serum Tβ4 and HDL (P = 0.034).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605701
02HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated positively with HDL.
In plain wordsHigher body's own Tβ4 was linked to higher HDL.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseCorrelation of serum Tβ4 with HDL
Study
n = 80
Outcome group
Lipids · Liver
Source sentences
Summary
Serum Tβ4 was significantly lower in NAFLD patients (P < 0.001) and there was a significant positive correlation between serum Tβ4 and HDL (P = 0.034).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605702
03HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with waist circumference.
In plain wordsHigher body's own Tβ4 was linked to a smaller waist circumference.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with waist circumference
Study
n = 80
Outcome group
Body weight · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605703
04HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with total cholesterol level.
In plain wordsHigher body's own Tβ4 was linked to lower total cholesterol.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with total cholesterol
Study
n = 80
Outcome group
Lipids · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605704
05HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with insulin level.
In plain wordsHigher body's own Tβ4 was linked to lower insulin levels.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with insulin level
Study
n = 80
Outcome group
Glycemic control · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605705
06HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with HOMA-IR.
In plain wordsHigher body's own Tβ4 was linked to lower insulin resistance.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with HOMA-IR
Study
n = 80
Outcome group
Glycemic control · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605706
07HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with serum triglycerides.
In plain wordsHigher body's own Tβ4 was linked to lower triglycerides.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with triglycerides
Study
n = 80
Outcome group
Lipids · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605707
08HumanEndogenous levelObservational studyOther
Serum Tβ4 correlated negatively with the fatty liver index.
In plain wordsHigher body's own Tβ4 was linked to a lower fatty liver index.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCorrelation of serum Tβ4 with fatty liver index
Study
n = 80
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
On the other hand, there was a significant negative correlation between serum Tβ4 and waist circumference (P < 0.001), total cholesterol level (P < 0.001), insulin level (P < 0.001), HOMA-IR (P < 0.001), serum triglycerides (P= 0.025) and FLI (P = 0.004).
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605708
09HumanEndogenous levelObservational studyOther
At a cut-off of 900 ng/ml or lower, serum Tβ4 had 100% sensitivity and 100% specificity for predicting NAFLD.
In plain wordsA blood level of the body's own Tβ4 at or below 900 ng/ml identified fatty liver in this study.
Peptide
Thymosin beta-4 (human)
Outcome
Not applicableDiagnostic accuracy of serum Tβ4 for NAFLD at cut-off 900 ng/ml
Study
n = 80
Outcome group
Liver fat and liver function · Liver
Measurements
sensitivity
100%
serum Tβ4 cut-off ≤900 ng/ml
specificity
100%
serum Tβ4 cut-off ≤900 ng/ml
Source sentences
Summary
Serum Tβ4 at a cut-off value of ≤900 ng/ml had 100 % sensitivity, 100 % specificity, 100% positive predictive value and 100% negative predictive value for the prediction of NAFLD.
1 context sentence(design, population, supporting numbers)
Summary · context
Eighty patients were enrolled in this study, divided into two equal groups of NAFLD cases (n=40) and a control group (n=40).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3543605709

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

PepBank is a research reference. Talk to a doctor before you use any peptide.