The effect of kisspeptin on the functional activity of peripheral blood monocytes and neutrophils in the context of physiological pregnancy.

Gorbunova O, Shirshev S

Journal of reproductive immunology6 Apr 2022Cited by 3 (Europe PMC)

PMID35413647DOI10.1016/j.jri.2022.103621PepBankPUB-35413647

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Activity measurement
In cultured neutrophils from healthy non-pregnant women, kisspeptin‑54 inhibited phagocytosis.
In plain wordsIn lab tests on human neutrophils, kisspeptin‑54 reduced their ability to engulf bacteria.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseNeutrophil phagocytosis
Study
humann: not reported in source
neutrophils from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
It was revealed that kisspeptin-54 inhibits phagocytosis, MPO and ROS of neutrophils.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364701
02LabIn vitro (cells)Activity measurement
In cultured neutrophils from healthy non-pregnant women, kisspeptin‑54 inhibited myeloperoxidase activity.
In plain wordsIn lab tests on human neutrophils, kisspeptin‑54 lowered myeloperoxidase activity.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseNeutrophil myeloperoxidase activity
Study
humann: not reported in source
neutrophils from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
It was revealed that kisspeptin-54 inhibits phagocytosis, MPO and ROS of neutrophils.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364702
03LabIn vitro (cells)Activity measurement
In cultured neutrophils from healthy non-pregnant women, kisspeptin‑54 inhibited reactive oxygen species production.
In plain wordsIn lab tests on human neutrophils, kisspeptin‑54 lowered production of reactive oxygen species.
Peptide
Kisspeptin-54 (metastin)
Outcome
DecreaseNeutrophil reactive oxygen species production
Study
humann: not reported in source
neutrophils from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
It was revealed that kisspeptin-54 inhibits phagocytosis, MPO and ROS of neutrophils.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364703
04LabIn vitro (cells)Activity measurement
In cultured monocytes from healthy non-pregnant women, kisspeptin‑54 activated phagocytosis.
In plain wordsIn lab tests on human monocytes, kisspeptin‑54 increased their ability to engulf bacteria.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMonocyte phagocytosis
Study
humann: not reported in source
monocytes from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
On the contrary, the hormone activates phagocytosis, MPO activity, ROS production and IDO activity of monocytes.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364704
05LabIn vitro (cells)Activity measurement
In cultured monocytes from healthy non-pregnant women, kisspeptin‑54 activated myeloperoxidase activity.
In plain wordsIn lab tests on human monocytes, kisspeptin‑54 raised myeloperoxidase activity.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMonocyte myeloperoxidase activity
Study
humann: not reported in source
monocytes from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
On the contrary, the hormone activates phagocytosis, MPO activity, ROS production and IDO activity of monocytes.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364705
06LabIn vitro (cells)Activity measurement
In cultured monocytes from healthy non-pregnant women, kisspeptin‑54 activated reactive oxygen species production.
In plain wordsIn lab tests on human monocytes, kisspeptin‑54 raised production of reactive oxygen species.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMonocyte reactive oxygen species production
Study
humann: not reported in source
monocytes from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
On the contrary, the hormone activates phagocytosis, MPO activity, ROS production and IDO activity of monocytes.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364706
07LabIn vitro (cells)Activity measurement
In cultured monocytes from healthy non-pregnant women, kisspeptin‑54 activated indolamine-2,3-dioxygenase activity.
In plain wordsIn lab tests on human monocytes, kisspeptin‑54 raised IDO activity.
Peptide
Kisspeptin-54 (metastin)
Outcome
IncreaseMonocyte indolamine-2,3-dioxygenase activity
Study
humann: not reported in source
monocytes from healthy non-pregnant women
Outcome group
Immune response · Immune and inflammation
Studied dose
concentrations comparable to the level during physiological pregnancy · 1 hAs given in this study (human).
Source sentences
Summary
On the contrary, the hormone activates phagocytosis, MPO activity, ROS production and IDO activity of monocytes.
2 context sentences(design, population, supporting numbers)
Summary · context
The aim of the study was investigation of kisspeptin-54 effect in concentrations comparable to its level during physiological pregnancy on neutrophils and monocytes functional activity.
Summary · context
Cells were isolated from peripheral blood of healthy non-pregnant women and cultured with kisspeptin-54 for 1 h.
Report a problemFND-3541364707

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

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