Pramlintide: An Amylin Analogue Protects Endothelial Cells against Oxidative Stress through Regulating Oxidative Markers and NF-κb Expression.

Safaeian L, Shafiee F, Naderi M

International journal of preventive medicine8 Feb 2022Cited by 6 (Europe PMC)

PMID35392304PMCIDPMC8980815DOI10.4103/ijpvm.ijpvm_425_20PepBankPUB-35392304

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In HUVECs, pramlintide at 5 μg/mL significantly reduced hydrogen peroxide-induced cytotoxicity.
In plain wordsIn cells, pramlintide at 5 μg/mL reduced toxicity caused by hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseCytotoxicity at lower concentration
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Cell viability and death · Cardiovascular
Studied dose
5 μg/mLAs given in this study (human).
Source sentences
Summary
Pramlintide significantly decreased the cytotoxicity caused by H₂O₂ at the concentrations of 5 and 10 μg/mL.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230401
02LabIn vitro (cells)Efficacy outcome
In HUVECs, pramlintide at 10 μg/mL significantly reduced hydrogen peroxide-induced cytotoxicity.
In plain wordsIn cells, pramlintide at 10 μg/mL reduced toxicity caused by hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseCytotoxicity at higher concentration
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Cell viability and death · Cardiovascular
Studied dose
10 μg/mLAs given in this study (human).
Source sentences
Summary
Pramlintide significantly decreased the cytotoxicity caused by H₂O₂ at the concentrations of 5 and 10 μg/mL.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230402
03LabIn vitro (cells)Mechanism
In HUVECs, pramlintide pretreatment reduced intracellular hydroperoxides compared with hydrogen peroxide-stimulated cells.
In plain wordsIn cells, pramlintide reduced internal hydroperoxides compared with cells stimulated with hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseIntracellular hydroperoxides
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of HUVECs with pramlintide reduced hydroperoxides and increased FRAP value in intra- and extra-cellular mediums at different concentration ranges compared with H₂O₂ stimulated cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230403
04LabIn vitro (cells)Mechanism
In HUVECs, pramlintide pretreatment reduced extracellular hydroperoxides compared with hydrogen peroxide-stimulated cells.
In plain wordsIn cells, pramlintide reduced external hydroperoxides compared with cells stimulated with hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
DecreaseExtracellular hydroperoxides
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of HUVECs with pramlintide reduced hydroperoxides and increased FRAP value in intra- and extra-cellular mediums at different concentration ranges compared with H₂O₂ stimulated cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230404
05LabIn vitro (cells)Mechanism
In HUVECs, pramlintide pretreatment increased intracellular FRAP compared with hydrogen peroxide-stimulated cells.
In plain wordsIn cells, pramlintide increased internal antioxidant capacity compared with cells stimulated with hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
IncreaseIntracellular FRAP
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of HUVECs with pramlintide reduced hydroperoxides and increased FRAP value in intra- and extra-cellular mediums at different concentration ranges compared with H₂O₂ stimulated cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230405
06LabIn vitro (cells)Mechanism
In HUVECs, pramlintide pretreatment increased extracellular FRAP compared with hydrogen peroxide-stimulated cells.
In plain wordsIn cells, pramlintide increased external antioxidant capacity compared with cells stimulated with hydrogen peroxide.
Peptide
Pramlintide (Symlin)
Outcome
IncreaseExtracellular FRAP
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Oxidative stress · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
Pretreatment of HUVECs with pramlintide reduced hydroperoxides and increased FRAP value in intra- and extra-cellular mediums at different concentration ranges compared with H₂O₂ stimulated cells.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230406
07LabIn vitro (cells)Mechanism
In HUVECs, pramlintide ameliorated NF-κB gene expression after 1, 3 and 24 h of hydrogen peroxide exposure; direction was unspecified.
In plain wordsIn cells, pramlintide improved NF-κB gene expression after hydrogen peroxide exposure, but the abstract does not specify the direction.
Peptide
Pramlintide (Symlin)
Outcome
Direction not reportedNF-κB gene expression
Study
humann: not reported in source
hydrogen peroxide-stimulated human umbilical vein endothelial cells
Comparator
hydrogen peroxide-stimulated cells
Outcome group
Inflammation markers · Cardiovascular
Studied dose
10 μg/mLAs given in this study (human).
Source sentences
Summary
Pramlintide (10 μg/mL) remarkably ameliorated the expression of NF-κB gene after 1, 3 and 24 h exposure to H₂O₂.
1 context sentence(design, population, supporting numbers)
Summary · context
The present investigation evaluated the effect of pramlintide against oxidative damage induced by hydrogen peroxide (H₂O₂) in human umbilical vein endothelial cells (HUVECs).
Report a problemFND-3539230407

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.