A GH Secretagogue Receptor Agonist (LUM-201) Elicits Greater GH Responses than Standard GH Secretagogues in Subjects of a Pediatric GH Deficiency Trial.

Bright GM, Thorner MO

Hormone research in paediatrics30 Mar 2022Cited by 7 (Europe PMC)

PMID35354138PMCIDPMC9227666DOI10.1159/000524244PepBankPUB-35354138

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

01HumanNon-randomized trialEfficacy outcome
In pediatric GH deficiency trial participants, LUM-201 elicited greater GH responses than standard diagnostic GH stimuli.
In plain wordsIn children in a growth hormone deficiency trial, LUM-201 produced greater growth hormone responses than standard diagnostic stimuli.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseGH response versus diagnostic stimuli
Study
n = 68
Comparator
GHD diagnostic tests with arginine, glucagon, clonidine, L-dopa, and insulin-induced hypoglycemia
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · oral · single doseAs given in this study (human).
Measurements
Median GH response
15 ng/mL
LUM-201
Median GH response
5.5 ng/mL
standard diagnostic stimuli
Interquartile range of GH response
3.5 to 49 ng/mL
LUM-201, median GH response 15.0 ng/mL
Interquartile range of GH response
1.8 to 7.6 ng/mL
standard diagnostic stimuli, median GH response 5.5 ng/mL
p value for GH response comparison
< 0.0001 p value
LUM-201 versus GHD diagnostic tests with arginine, glucagon, clonidine, L-dopa, and insulin-induced hypoglycemia
Source sentences
Summary
LUM-201 elicited greater GH responses than observed in GHD diagnostic tests with arginine, glucagon, clonidine, L-dopa, and insulin-induced hypoglycemia [median and interquartile ranges 15.0 ng/mL (3.5, 49) vs. 5.5 ng/mL (1.8, 7.6) (p < 0.0001)].
1 context sentence(design, population, supporting numbers)
Summary · context
The GH response to a single dose of LUM-201 and to other GH secretagogues used for diagnosis of PGHD were compared in 68 pediatric subjects participating in a trial for growth hormone deficiency.
Report a problemFND-3535413801
02HumanNon-randomized trialEfficacy outcome
The LUM-201 versus standard-stimulus GH response difference was greatest in pediatric subjects with higher baseline IGF-I concentrations.
In plain wordsIn children, LUM-201's advantage over standard stimuli was greatest in those with higher baseline IGF-I levels.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseGH response difference by baseline IGF-I
Study
n: not reported in source
Comparator
standard GH stimuli (arginine, glucagon, clonidine, L-dopa, insulin-induced hypoglycemia)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · oral · single doseAs given in this study (human).
Source sentences
Summary
The difference between responses was greatest in subjects with higher baseline IGF-I concentrations and higher GH responses to standard GH stimuli.
2 context sentences(design, population, supporting numbers)
Summary · context
LUM-201 elicited greater GH responses than observed in GHD diagnostic tests with arginine, glucagon, clonidine, L-dopa, and insulin-induced hypoglycemia [median and interquartile ranges 15.0 ng/mL (3.5, 49) vs. 5.5 ng/mL (1.8, 7.6) (p < 0.0001)].
Summary · context
The GH response to a single dose of LUM-201 and to other GH secretagogues used for diagnosis of PGHD were compared in 68 pediatric subjects participating in a trial for growth hormone deficiency.
Report a problemFND-3535413802
03HumanNon-randomized trialEfficacy outcome
The LUM-201 versus standard-stimulus GH response difference was greatest in pediatric subjects with higher GH responses to standard stimuli.
In plain wordsIn children, LUM-201's advantage over standard stimuli was greatest in those with higher growth hormone responses to standard stimuli.
Peptide
MK-677 (ibutamoren)
Outcome
IncreaseGH response difference by standard-stimulus response
Study
n: not reported in source
Comparator
standard GH stimuli (arginine, glucagon, clonidine, L-dopa, insulin-induced hypoglycemia)
Outcome group
Growth hormone and IGF-1 · Endocrine and hormones
Studied dose
Dose not stated · oral · single doseAs given in this study (human).
Source sentences
Summary
The difference between responses was greatest in subjects with higher baseline IGF-I concentrations and higher GH responses to standard GH stimuli.
2 context sentences(design, population, supporting numbers)
Summary · context
LUM-201 elicited greater GH responses than observed in GHD diagnostic tests with arginine, glucagon, clonidine, L-dopa, and insulin-induced hypoglycemia [median and interquartile ranges 15.0 ng/mL (3.5, 49) vs. 5.5 ng/mL (1.8, 7.6) (p < 0.0001)].
Summary · context
The GH response to a single dose of LUM-201 and to other GH secretagogues used for diagnosis of PGHD were compared in 68 pediatric subjects participating in a trial for growth hormone deficiency.
Report a problemFND-3535413803

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.