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Study · Animal study (in vivo) · wistar rats and beagle dogs · 2022

6 results

Short- versus long-term, gender and species differences in the intestinotrophic effects of long-acting glucagon-like peptide 2 analog.

Glerup P, Sonne K, Berner-Hansen M, Skarbaliene J

Physiological research28 Mar 2022Cited by 5 (Europe PMC)

PMID35344672 (opens in a new tab)PMCIDPMC9150555 (opens in a new tab)DOI10.33549/physiolres.934839 (opens in a new tab)PepBankPUB-35344672
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, short- and long-term glepaglutide treatment produced significant dose-dependent intestinotrophic effects in both genders.

    In plain wordsIn rats and dogs, glepaglutide produced dose-dependent intestinal growth effects during short- and long-term treatment in both genders.

    Peptide
    Glepaglutide
    Outcome
    IncreaseDose-dependent intestinotrophic effect
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    Following both short- and long-term treatment with glepaglutide, a significant dose-dependent intestinotrophic effect was seen in both genders and species.
    1 context sentence
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, glepaglutide increased small intestinal length at all doses, without differences between genders.

    In plain wordsIn rats and dogs, glepaglutide increased small intestinal length at all doses, without differences between genders.

    Peptide
    Glepaglutide
    Outcome
    IncreaseSmall intestinal length
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders.
    1 context sentence
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, glepaglutide increased small intestinal weight at all doses, without differences between genders.

    In plain wordsIn rats and dogs, glepaglutide increased small intestinal weight at all doses, without differences between genders.

    Peptide
    Glepaglutide
    Outcome
    IncreaseSmall intestinal weight
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders.
    1 context sentence
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, glepaglutide produced macroscopic thickening in all small intestinal segments, without differences between genders.

    In plain wordsIn rats and dogs, glepaglutide produced visible thickening in all small intestinal segments, without differences between genders.

    Peptide
    Glepaglutide
    Outcome
    IncreaseMacroscopic intestinal thickening
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders.
    1 context sentence
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, glepaglutide produced villous hypertrophy in all small intestinal segments, without differences between genders.

    In plain wordsIn rats and dogs, glepaglutide enlarged intestinal villi in all small intestinal segments, without differences between genders.

    Peptide
    Glepaglutide
    Outcome
    IncreaseVillous hypertrophy
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders.
    1 context sentence
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In rats and dogs, glepaglutide-associated intestinal morphology findings persisted after a 6-week recovery period.

    In plain wordsIn rats and dogs, intestinal growth findings persisted after a 6-week recovery period following glepaglutide treatment.

    Peptide
    Glepaglutide
    Outcome
    Not applicablePersistence of intestinal morphology findings
    Study

    Wistar rats and Beagle dogsn: not reported in source

    Wistar rats and Beagle dogs of both genders
    Outcome group
    Intestinal growth and absorption · Gastrointestinal
    Studied dose
    Dose not stated · 1 week or 26-39 weeksAs given in this study (Wistar rats and Beagle dogs).

    Source sentences

    Summary
    The findings were still present following a 6-week recovery period, indicating long-acting intestinotrophic effects of glepaglutide.
    2 context sentences
    Summary · context
    At all doses increased length and weight of the small intestine as well as macroscopic thickening and villous hypertrophy were noted in all segments of the small intestine, without any differences between genders.
    Summary · context
    The objective of this work was to compare the small intestinal trophic effects in both genders following short (1 week) versus long-term (26-39 weeks) GLP-2 treatment in Wistar rats and Beagle dogs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    27 Oct 2026, 18:20 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:32 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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